Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution

Drug Resistance Updates, Journal Year: 2019, Volume and Issue: 44, P. 100640 - 100640

Published: May 1, 2019

Language: Английский

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Toxicity drives facilitation between 4 bacterial species

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(32), P. 15979 - 15984

Published: July 3, 2019

Competition between microbes is extremely common, with many investing in mechanisms to harm other strains and species. Yet positive interactions species have also been documented. What makes help or each currently unclear. Here, we studied the 4 bacterial capable of degrading metal working fluids (MWF), an industrial coolant lubricant, which contains growth substrates as well toxic biocides. We were surprised find only neutral Using mathematical modeling further experiments, show that this community likely due toxicity MWF, whereby species' detoxification benefited others by facilitating their survival, such they could grow degrade MWF better when together. The addition nutrients, reduction toxicity, more instead resulted competitive behavior. Our work provides support stress gradient hypothesis showing how harsh, environments can strongly favor facilitation microbial mask underlying interactions.

Language: Английский

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Deciphering the transfers of antibiotic resistance genes under antibiotic exposure conditions: Driven by functional modules and bacterial community

Water Research, Journal Year: 2021, Volume and Issue: 205, P. 117672 - 117672

Published: Sept. 17, 2021

Language: Английский

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Antibiotic contamination in wastewater treatment plant effluents: Current research and future perspectives

Environmental Nanotechnology Monitoring & Management, Journal Year: 2025, Volume and Issue: unknown, P. 101047 - 101047

Published: Jan. 1, 2025

Language: Английский

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Environmentally Mediated Social Dilemmas

Trends in Ecology & Evolution, Journal Year: 2018, Volume and Issue: 34(1), P. 6 - 18

Published: Nov. 8, 2018

Language: Английский

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Biofilm architecture: An emerging synthetic biology target

Synthetic and Systems Biotechnology, Journal Year: 2020, Volume and Issue: 5(1), P. 1 - 10

Published: Jan. 13, 2020

Synthetic biologists are exploiting biofilms as an effective mechanism for producing various outputs. Metabolic optimization has become commonplace a method of maximizing system output. In addition to production pathways, the biofilm itself contributes efficacy production. The purpose this review is highlight opportunities that might be leveraged further enhance in preexisting systems. These may used with previously established systems improving efficiency further. This accomplished through reduction cost establishing and maintaining biofilms, maintenance enhancement product yield per unit time, area, or required input.

Language: Английский

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Ten recent insights for our understanding of cooperation

Nature Ecology & Evolution, Journal Year: 2021, Volume and Issue: 5(4), P. 419 - 430

Published: Jan. 28, 2021

Language: Английский

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From competition to facilitation and mutualism: a general theory of the niche

Ecological Monographs, Journal Year: 2021, Volume and Issue: 91(3)

Published: April 23, 2021

Abstract Niche Theory is a central framework in ecology based on the recognition that most interactions between organisms are indirect, mediated by biotic and abiotic dynamical environment these live in. Despite its potential generality, theory still mostly focuses how resource–consumer dynamics mediate competition ecological communities. However, it being increasingly recognized positive also play an important role driving structure functioning of communities, from plants to microbes. In this paper, we present unified niche applies both negative organisms, one or two environmental factors. We show classical concepts such as differences fundamental realized niches can naturally be expanded facilitative mutualistic interactions. addition, introduce formalize new general appear exclusively presence interactions: (1) Allee niche, region conditions for which species persist but not invade low densities (2) facilitation, when expands set under second and/or persist. To broad applicability theory, illustrate using diverse theoretical examples, bacteria feeding inhibiting substrate, nitrogen‐fixing indirect mutualism plant carnivore species. sum, our work shows provides natural ecology, bringing perspective conceptual tools study systems where occur.

Language: Английский

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The evolution of the type VI secretion system as a disintegration weapon

PLoS Biology, Journal Year: 2020, Volume and Issue: 18(5), P. e3000720 - e3000720

Published: May 26, 2020

The type VI secretion system (T6SS) is a nanomachine used by many bacteria to drive toxin-laden needle into other bacterial cells. Although the potential influence competition clear, fitness impacts of wielding T6SS are not well understood. Here we present new agent-based model that enables detailed study evolutionary costs and benefits weaponry during with bacteria. Our identifies key problem T6SS. Because its short range, activity becomes self-limiting, as dead cells accumulate in way, forming "corpse barriers" block further attacks. However, exploration presented solution this problem: if injected toxins can quickly lyse target addition killing them, much more effective weapon. We tested prediction single-cell analysis combat between T6SS-wielding Acinetobacter baylyi T6SS-sensitive Escherichia coli. As predicted, delivery lytic highly effective, whereas nonlytic leave large patches E. coli alive. then analyzed hundreds species using published genomic data, which suggest great majority do indeed use toxins, indicative general principle underlying weapon evolution. work suggests that, T6SS, have evolved disintegration whose effectiveness often rests upon ability break up competitors. Understanding function weapons help design probiotics both establish eliminate species.

Language: Английский

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Community interactions and spatial structure shape selection on antibiotic resistant lineages

PLoS Computational Biology, Journal Year: 2018, Volume and Issue: 14(6), P. e1006179 - e1006179

Published: June 21, 2018

Polymicrobial interactions play an important role in shaping the outcome of antibiotic treatment, yet how multispecies communities respond to assault is still little understood. Here we use individual-based simulation model microbial biofilms investigate competitive and mutualistic between antibiotic-resistant a susceptible strain (or species) influence two-lineage community response exposure. Our predicts that while increasing competition antibiotics leads release strain, hitting cross-feeding species with suppression effect where both resistant are harmed. We next show impact further governed by emergent spatial feedbacks within communities. Mutualistic can rescue members subsidizing their growth inside biofilm despite lack access nutrient-rich high-antibiotic growing front. Moreover, detoxification cells protect nearby cells, but such cross-protection more effective because mutualism drives mixing cells. In contrast, segregation, which ultimately prevents profit from detoxification. Understanding interplay metabolic structuring shapes treatment be key effectively leverage power promote microbiome health.

Language: Английский

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