Local molecular and global connectomic contributions to cross-disorder cortical abnormalities DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Jacob W. Vogel

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 10, 2022

Abstract Numerous brain disorders demonstrate structural abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these connectomic vulnerabilities remain unknown, has yet be studied in a single multi-disorder framework. Using MRI morphometry the ENIGMA consortium, we construct maps cortical abnormalities for thirteen neurodevelopmental, neurological, psychiatric N = 21,000 participants 26,000 controls, collected using harmonised processing protocol. We systematically compare multiple micro-architectural measures, including gene expression, neurotransmitter density, metabolism, myelination (molecular vulnerability), as well global measures number connections, centrality, connection diversity (connectomic vulnerability). find relationship between vulnerability white-matter architecture that drives disorder profiles. Local attributes, particularly receptor profiles, constitute best predictors both disorder-specific morphology cross-disorder similarity. Finally, consistently subtended by small subset network epicentres bilateral sensory-motor, inferior temporal lobe, precuneus, superior parietal cortex. Collectively, our results highlight how local attributes connectivity jointly shape abnormalities.

Language: Английский

Genetics and neurobiology of eating disorders DOI
Cynthia M. Bulik, Jonathan R. I. Coleman,

J. Andrew Hardaway

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(5), P. 543 - 554

Published: May 1, 2022

Language: Английский

Citations

89
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group DOI
Esther Walton, Fabio Bernardoni, Victoria-Luise Batury

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(9), P. 730 - 738

Published: June 1, 2022

Language: Английский

Citations

84
Evolutionary Global Neuroscience for Cognition and Brain Health DOI
Bhupinder Singh

Advances in bioinformatics and biomedical engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 246 - 272

Published: March 4, 2024

The evolutionary foundations of brain development represent point departure. It delves into the depths history, unveiling intricate journey that has shaped human brain. Comparative neuroanatomy and phylogeny provide canvas upon which we paint portrait our cognitive evolution. contemplates constraints, both genetic epigenetic, have sculpted brain's architecture. These insights serve as bedrock Evolutionary Global Neuroscience stands. In quest to unlock enigmatic complexities brain, emerges a transformative paradigm transcends disciplinary boundaries. This expansive field explores profound interplay between heritage contemporary challenges in cognition, health, ever-evolving landscape neurotechnology. Cognition, quintessential hallmark existence, is next claim attention. interrogate adaptive value cognition across epochs, deciphering its role survival prosperity. Yet, this age rapid societal transformation, concept “evolutionary mismatch” comes fore. explore how mismatch underlies burgeoning epidemic disorders, underscoring urgent need for new addressing health. paper illuminates grim modernity's disorders. Alzheimer's disease autism spectrum disorders poignant exemplars puzzle engulfs us. From predispositions environmental influences, it multifaceted origins these ever mindful shadows cast by history. promise Neuroscience, however, not confined diagnosis treatment. extends innovative approaches safeguard well-being. Drawing inspiration from past, uncovers preventive strategies, therapeutic interventions, personalized medicine approaches. Lifestyle modifications adaptations emerge potent tools preserving resilience. Amidst journey, neurotechnology catalyst innovation. Neuroimaging, brain-machine interfaces, neuromodulation, artificial intelligence converge redefine boundaries exploration. fusion biology technology holds key unlocking frontiers science, offering hope individuals grappling with propels ourselve toward novel discoveries, confront an array ethical challenges. Questions enhancement, informed consent, privacy, equitable access neurotechnological advancements loom large. Our abstract engages considerations, advocating responsible innovation harmonizes values. merely scientific endeavor; call action. beckons us unite disciplines, fostering interdisciplinary collaboration borders cultures. urges invest longitudinal cross-cultural research expands understanding exquisite diversity. demands commitment health literacy thoughtful policy recommendations ensure fruits advancement are accessible all. journeyed through realm begins past charts course enlightened, innovative, future mind.

Language: Английский

Citations

83
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders DOI Creative Commons
Meike D. Hettwer, Sara Larivière, Bo‐yong Park

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 11, 2022

Abstract Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients 18,969 controls from the ENIGMA consortium, observed that patterns followed normative connectome organization were anchored to prefrontal temporal disease epicenters. Manifold learning revealed frontal-to-temporal sensory/limbic-to-occipitoparietal gradients, differentiating shared illness effects on thickness along these axes. The principal gradient aligned with covariance established transcriptomic link cortico-cerebello-thalamic circuits. Moreover, gradients segregated functional involved basic sensory, attentional/perceptual, domain-general cognitive processes, distinguished between regional cytoarchitectonic profiles. Together, our findings indicate occur synchronized fashion multiple levels of hierarchical organization.

Language: Английский

Citations

80
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Jacob W. Vogel

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 10, 2022

Abstract Numerous brain disorders demonstrate structural abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these connectomic vulnerabilities remain unknown, has yet be studied in a single multi-disorder framework. Using MRI morphometry the ENIGMA consortium, we construct maps cortical abnormalities for thirteen neurodevelopmental, neurological, psychiatric N = 21,000 participants 26,000 controls, collected using harmonised processing protocol. We systematically compare multiple micro-architectural measures, including gene expression, neurotransmitter density, metabolism, myelination (molecular vulnerability), as well global measures number connections, centrality, connection diversity (connectomic vulnerability). find relationship between vulnerability white-matter architecture that drives disorder profiles. Local attributes, particularly receptor profiles, constitute best predictors both disorder-specific morphology cross-disorder similarity. Finally, consistently subtended by small subset network epicentres bilateral sensory-motor, inferior temporal lobe, precuneus, superior parietal cortex. Collectively, our results highlight how local attributes connectivity jointly shape abnormalities.

Language: Английский

Citations

73