The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review DOI Creative Commons
Arezoo Faridzadeh, Arefeh Tabashiri, Hamid Heidarian Miri

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 8(10), P. e10906 - e10906

Published: Oct. 1, 2022

IntroductionSince November 2019, the world has been grappling with rapid spread of Coronavirus disease 2019 (COVID-19). In response to this major health crisis, first vaccination rollout was launched in December 2020. However, even fully vaccinated individuals are not completely immune infection, albeit less severe symptoms. Melatonin is known as an anti-oxidant, anti-inflammatory, and immunomodulatory agent whose anti-viral properties, cost-effectiveness, relatively few side effects make it a potential adjuvant treatment COVID-19. This systematic review aims summarize clinical studies on melatonin COVID-19 patients.MethodsThe search articles carried out Web Science, PubMed/MEDLINE, Cochrane library, Scopus databases up January 2022.ResultsTen were included our study. It seems can decrease inflammatory markers, cytokines, expression some genes, including signal transducer activator transcription (STAT)4, STAT6, T-box expressed T cell (T-bet), GATA binding protein 3 (GATA3), apoptosis-associated speck-like containing caspase recruitment domain (ASC), caspase-1 (CASP1). addition, appears alleviate signs symptoms accelerate recovery. The use cases reduces thrombosis, sepsis, mortality rate.ConclusionThis highlights probable role after about two weeks consumption. further high-quality randomized trials required.

Language: Английский

Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders DOI
Aditi Giri, Sidharth Mehan, Zuber Khan

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(6), P. 3867 - 3895

Published: Jan. 16, 2024

Language: Английский

Citations

4
Melatonin Ameliorates Post-Stroke Cognitive Impairment in Mice by Inhibiting Excessive Mitophagy DOI Creative Commons
Yan Shi, Fang Qian,

Hu Yue

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 872 - 872

Published: May 18, 2024

Post-stroke cognitive impairment (PSCI) remains the most common consequence of ischemic stroke. In this study, we aimed to investigate role and mechanisms melatonin (MT) in improving dysfunction stroke mice. We used CoCl2-induced hypoxia-injured SH-SY5Y cells as a cellular model photothrombotic-induced mice an animal model. found that stroke-induced upregulation mitophagy, apoptosis, neuronal synaptic plasticity was impaired both vivo vitro. The results novel object recognition test Y-maze showed significant deficits mice, Nissl staining loss neurons contrast, MT inhibited excessive mitophagy vitro decreased levels proteins PINK1 Parkin, immunofluorescence reduced co-localization Tom20 LC3. A inhibition could be directly observed under transmission electron microscopy. Furthermore, behavioral experiments ameliorated following Our demonstrated inhibits improves PSCI. These findings highlight potential preventive drug for PSCI, offering promising therapeutic implications.

Language: Английский

Citations

4
27-Hydroxymangiferolic Acid Extends Lifespan and Improves Neurodegeneration in Caenorhabditis elegans by Activating Nuclear Receptors DOI Creative Commons
Xiaoyan Gao,

Jing Yu,

Li Yin

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1010 - 1010

Published: Feb. 21, 2025

27-Hydroxymangiferolic acid (27-HMA) is a naturally occurring compound in mango fruits that exhibits diverse biological functions. Here, we show 27-HMA activates the transcriptional activity of farnesoid X receptor (FXR), nuclear transcription factor, extending lifespan and healthspan Caenorhabditis elegans (C. elegans). Meanwhile, longevity-promoting effect was attenuated mutants nhr-8 daf-12, FXR homologs, indicating longevity effects C. may depend on hormone receptors (NHRs). Further analysis revealed potential associations between insulin/insulin-like growth factor-1 signaling (IIS)/TORC1 pathway. Moreover, increased toxin resistance nematodes activated expression detoxification genes, which rely NHRs. Finally, improved age-related neurodegeneration Alzheimer's disease (AD) Parkinson's (PD) models. Taken together, our findings suggest novel agonist prolong via activating

Language: Английский

Citations

0
Melatonin protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide25–35 DOI

Karen del Carmen Barboza Salgado,

R. Nascimento,

Ana Luíza Spadano Albuquerque

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149637 - 149637

Published: April 1, 2025

Language: Английский

Citations

0
The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review DOI Creative Commons
Arezoo Faridzadeh, Arefeh Tabashiri, Hamid Heidarian Miri

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 8(10), P. e10906 - e10906

Published: Oct. 1, 2022

IntroductionSince November 2019, the world has been grappling with rapid spread of Coronavirus disease 2019 (COVID-19). In response to this major health crisis, first vaccination rollout was launched in December 2020. However, even fully vaccinated individuals are not completely immune infection, albeit less severe symptoms. Melatonin is known as an anti-oxidant, anti-inflammatory, and immunomodulatory agent whose anti-viral properties, cost-effectiveness, relatively few side effects make it a potential adjuvant treatment COVID-19. This systematic review aims summarize clinical studies on melatonin COVID-19 patients.MethodsThe search articles carried out Web Science, PubMed/MEDLINE, Cochrane library, Scopus databases up January 2022.ResultsTen were included our study. It seems can decrease inflammatory markers, cytokines, expression some genes, including signal transducer activator transcription (STAT)4, STAT6, T-box expressed T cell (T-bet), GATA binding protein 3 (GATA3), apoptosis-associated speck-like containing caspase recruitment domain (ASC), caspase-1 (CASP1). addition, appears alleviate signs symptoms accelerate recovery. The use cases reduces thrombosis, sepsis, mortality rate.ConclusionThis highlights probable role after about two weeks consumption. further high-quality randomized trials required.

Language: Английский

Citations

18