Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(3), P. 366 - 381.e9

Published: Feb. 26, 2024

Language: Английский

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The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 27, 2024

Obesity and chronic low-grade inflammation, often occurring together, significantly contribute to severe metabolic inflammatory conditions like type 2 diabetes (T2D), cardiovascular disease (CVD), cancer. A key player is elevated levels of gut dysbiosis-associated lipopolysaccharide (LPS), which disrupts immune signaling leading endotoxemia, while short-chain fatty acids (SCFAs) beneficially regulate these processes during homeostasis. SCFAs not only safeguard the barrier but also exert immunomodulatory effects via G protein-coupled receptor binding epigenetic regulation. are emerging as potential agents counteract dysbiosis-induced changes, specifically targeting genes through DNA methylation, histone acetylation, microRNAs (miRNAs), long non-coding RNAs (lncRNAs). To assess whether can effectively interrupt detrimental cascade obesity this review aims provide a comprehensive overview current evidence for their clinical application. The emphasizes factors influencing SCFA production, intricate connections between metabolism, system, microbiome, mechanisms regulated by that impact metabolism system.

Language: Английский

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Gut microbiota signatures of long-term and short-term plant-based dietary pattern and cardiometabolic health: a prospective cohort study

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: June 15, 2022

Abstract Background The interplay among the plant-based dietary pattern, gut microbiota, and cardiometabolic health is still unclear, evidence from large prospective cohorts rare. We aimed to examine association of long-term short-term patterns with microbiota assess identified microbial features biomarkers. Methods Using a population-based cohort study: China Health Nutrition Survey, we included 3096 participants 15 provinces/megacities across China. created an overall diet index (PDI), healthful (hPDI), unhealthful (uPDI). average PDIs were calculated using repeat food frequency questionnaires collected in 2011 2015 represent pattern. Short-term pattern was estimated 3-day 24-h recalls 2015. Fecal samples measured 16S rRNA sequencing. investigated diversity, taxonomies, functional pathways linear mixed models. Furthermore, assessed associations between microbiome signatures biomarkers (measured 2018) regression. Results found significant hPDI alpha-diversity. Both indices correlated structure, whereas estimates explained more variance. Long-term differently associated taxonomic composition, yet only microbes related showed future Higher PDI lower relative abundance Peptostreptococcus , while this microbe positively high-sensitivity C-reactive protein inversely high-density lipoprotein cholesterol. Conclusions shared distinct patterns. genera may provide insights into protective role for health, replication independent needed.

Language: Английский

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Microbiota-gut-brain axis drives overeating disorders

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(11), P. 2011 - 2027.e7

Published: Oct. 3, 2023

Language: Английский

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Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154842 - 154842

Published: April 28, 2023

Language: Английский

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Are gut dysbiosis, barrier disruption, and endotoxemia related to adipose tissue dysfunction in metabolic disorders? Overview of the mechanisms involved

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 18(5), P. 1287 - 1302

Published: April 4, 2023

Abstract Recently, compelling evidence points to dysbiosis and disruption of the epithelial intestinal barrier as major players in pathophysiology metabolic disorders, such obesity. Upon disruption, components from bacterial metabolism bacteria itself can reach peripheral tissues through circulation. This has been associated with low-grade inflammation that characterizes obesity other diseases. While circulating DNA postulated a common feature even type 2 diabetes, almost no focus given existence effects tissues, namely adipose tissue. As symbiont population, it is expected gut microbiota modulate immunometabolism host, thus influencing energy balance mechanisms inflammation. Gut inflammatory signals cause direct deleterious responses tissue may also affect key neuroendocrine governing nutrient sensing balance, like incretins ghrelin, which play role gut-brain-adipose axis. Thus, importance disclose how derived pathways, contribute dysfunction sequelae related disorders. review summarizes current knowledge regarding these topics identifies new perspectives this field research, highlighting pathways toward reduction burden

Language: Английский

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The Gut Microbiota and Chronic Pain

Current Pain and Headache Reports, Journal Year: 2024, Volume and Issue: 28(4), P. 259 - 269

Published: Feb. 12, 2024

Language: Английский

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Effects of complex polysaccharides by Ficus carica Linn. polysaccharide and peach gum on the development and metabolites of human gut microbiota

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 154, P. 110061 - 110061

Published: April 7, 2024

Language: Английский

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Microbiota–neuroepithelial signalling across the gut–brain axis

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Neuroprotective Role of Lactoferrin during Early Brain Development and Injury through Lifespan

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2923 - 2923

Published: July 17, 2022

Early adverse fetal environments can significantly disturb central nervous system (CNS) development and subsequently alter brain maturation. Nutritional status is a major variable to be considered during increasing evidence links neonate preterm infant impaired growth with neurological psychiatric diseases in adulthood. Breastfeeding one of the main components required for healthy newborn due many "constitutive" elements breastmilk contains. Maternal intake specific nutrients lactation may milk composition, thus affecting nutrition and, potentially, development. Lactoferrin (Lf) protein present colostrum human milk, which plays an important role benefits breastfeeding postnatal It has been demonstrated that Lf antimicrobial, as well anti-inflammatory properties, potentially able reduce incidence sepsis necrotizing enterocolitis (NEC), are particularly frequent premature births. The effects birth-related pathologies by decreasing release pro-inflammatory factors inhibiting cervix maturation (also related commensal microbiome abnormalities) could contribute disrupting Pre-clinical shows protects developing from neuronal injury, enhances connectivity neurotrophin production, decreases inflammation models perinatal inflammatory challenge, intrauterine restriction (IUGR) neonatal hypoxia-ischemia (HI). In this context, provide nutritional support cognition prevent origin neuropsychiatric later life. narrative review, we consider certain neurodevelopment linking latest research on lactoferrin respect neonatology. We also discuss new indicating early neuroprotective pathways modulated neurodegeneration through immunomodulatory processes.

Language: Английский

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