Adverse childhood experiences and psychological distress among Chinese college students: the moderating effects of physical activity and sleep duration

International Journal of Sport and Exercise Psychology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 20, 2025

Language: Английский

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A Comprehensive Overview of Stress, Resilience, and Neuroplasticity Mechanisms

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3028 - 3028

Published: March 26, 2025

Stress is a core concept in the mental health field that expands upon seminal definition of stress as an acute response to disruption homeostasis. complex process involves both environmental challenges and triggering internal responses impacts physiological, psychological, behavioral systems. The capacity human brain cope with particularly crucial early life, when neurodevelopment highly plastic. Early-life (ELS), defined exposure severe chronic during sensitive periods development, has been shown cause lasting changes structure function. However, not all individuals exposed ELS develop pathological outcomes, suggesting presence resilience mechanisms: adaptive processes allow individual adverse situations while maintaining psychological neurobiological health. aim this review was synthesize recent advances understanding neuroplasticity mechanisms underlying ELS. We discussed pathways implicated adaptation, including roles neurogenesis, synaptic plasticity, neural circuit remodeling. By focusing on interplay between stress-induced neuroplastic mechanisms, we aimed provide insights into potential therapeutic targets for stress-related psychopathology.

Language: Английский

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Timing of exposure to household poverty and adolescent mental health problems

Epidemiology and Psychiatric Sciences, Journal Year: 2025, Volume and Issue: 34

Published: Jan. 1, 2025

Abstract Aims Mental health problems in adolescence are increasingly prevalent and have tremendous impacts on life-long mortality. Although household poverty is a known risk factor for adolescent mental health, evidence of the timing hypothesis scarce. We aimed to examine longitudinal associations across childhood with adolescence, focusing exposure. Methods used data 5,671 children from Japanese population-based cohort, which recruited first graders (aged 6–7 years) followed biannually until eighth grade 13–14 Adachi, Tokyo. Household was defined as households having any following experiences: annual income less than yen 3 million, payment difficulties material deprivations, measured first, second, fourth, sixth grades. Adolescent included parent-report internalizing externalizing (the Strengths Difficulties Questionnaire), self-report depression Patient Health Questionnaire-9) self-esteem version Children’s Perceived Competence Scale) grade. applied g-estimation structural nested mean modelling account time-varying confounders. Results If adolescents were exposed at childhood, average, they would report more severe depressive symptoms (ψ = 0.32 [95% CI 0.13; 0.51]) lower −0.41 [−0.62; −0.21]) There also average 0.19 [0.10; 0.29]) 0.10 [0.002; 0.19]). between stronger younger ages (e.g., second → depression: ψ 0.54 [−0.12; 1.19] vs. −0.01 [−0.66; 0.64]), overlapping 95% CIs indicated no statistically significantly different by Conclusion found effect exposure outcomes grade, failing support hypothesis. The findings indicate that effects accumulate over time impact (cumulative hypothesis) rather differ While cumulative suggest persistent intervention poor we highlight may be effective alleviating problems.

Language: Английский

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Early-life gut microbiome development and its potential long-term impact on health outcomes

Microbiome Research Reports, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 17, 2025

The initial gut colonization of the infant plays a pivotal role in shaping immune system, developing intestinal tract, and influencing host metabolism, all which are strongly influenced by several determinants, such as gestational age at birth, mode delivery, neonatal feeding practices, early-life stress (ELS), exposure to perinatal antibiotics. However, resulting microbiome (GM) dysbiosis may alter this developmental programming, leading long-term adverse health outcomes. This narrative review synthesizes current knowledge on GM development its impact health. Specifically, it addresses how affect trajectory physiological processes, predisposing individuals conditions allergic diseases, metabolic disorders, type 1 diabetes, inflammatory bowel atherosclerotic cardiovascular diseases. In addition, examines influence probiotic prebiotic supplementation during pregnancy early life composition, well ELS-induced mental Recent research suggests that microbiota initiates long-lasting effects, inadequate or insufficient microbial triggers responses associated with conditions. Although studies have reported connection between ELS both prenatal postnatal periods, unified signature linked either remains be fully elucidated. Thus, future needed establish causality determine whether modifiable factors affecting could targeted improve health, especially children exposed contextual

Language: Английский

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Dissociative symptoms in school-aged adopted children who experienced maternal separation and disruptive caregiving in infancy

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Amounting findings on maternal separation and early disturbed caregiving suggest that this type of experience negatively influences socioemotional development may be associated with behavioral mental health problems in later life. Concerning previously published studies, we have assessed if disrupted before adoption infancy could related to heightened levels dissociative symptoms middle childhood. We involved 30 children (sample S1) who had experienced after birth short-term institutional or foster care prior 16.7 months age. Based the parents’ reports, they not any other significant adversities by time evaluation. These were compared a control group lived their biological mothers complete families S2; N = 25). Although are correlational causal, indicate specific adverse experiences, birth, relatively short disruptive successful significantly school-aged children. Our data also contribute literature child etiology disorders.

Language: Английский

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Adolescent neurodevelopment and psychopathology: The interplay between adversity exposure and genetic risk for accelerated brain ageing

Developmental Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 60, P. 101229 - 101229

Published: March 15, 2023

In adulthood, stress exposure and genetic risk heighten psychological vulnerability by accelerating neurobiological senescence. To investigate whether molecular brain network maturation processes play a similar role in adolescence, we analysed genetic, as well longitudinal task neuroimaging (inhibitory control, incentive processing) early life adversity (i.e., material deprivation, violence) data from the Adolescent Brain Cognitive Development study (N = 980, age range: 9–13 years). Genetic was estimated separately for Major Depressive Disorder (MDD) Alzheimer's Disease (AD), two pathologies linked to allegedly sharing causal connection (MDD-to-AD). Adversity MDD/AD jointly predicted functional segregation patterns suggestive of accelerated (GABA-linked) visual/attentional, but delayed (dopamine [D2]/glutamate [GLU5R]-linked) somatomotor/association system development. A positive relationship between psychopathology emerged only among less vulnerable adolescents, thereby implying that normatively maladaptive neurodevelopmental alterations could foster adjustment more exposed genetically susceptible youths. Transcriptomic analyses suggested sensitivity may underpin joint effect MDD/AD, line with proposed negative emotionality precursor AD, likely account alleged impact MDD on dementia onset.

Language: Английский

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Maternal pandemic-related stress during pregnancy associates with infants’ socio-cognitive development at 12 months: A longitudinal multi-centric study

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(4), P. e0284578 - e0284578

Published: April 17, 2023

Background Prenatal maternal stress is a key risk factor for infants’ development. Previous research has highlighted consequences socio-emotional and cognitive outcomes, but less known what regards socio-cognitive In this study, we report on the effects of prenatal related to COVID-19 pandemic 12-month-old behavioral markers Methods Ninety infants their mothers provided complete longitudinal data from birth 12 months. At birth, reported pandemic-related during pregnancy. 12-month-age, remote mother-infant interaction was videotaped: after an initial 2-min face-to-face episode, experimenter remotely played series four auditory stimuli (2 human 2 non-human sounds). The sequence counterbalanced among participants each sound repeated three times every 10 seconds (Exposure, 30 seconds) while were instructed not interact with display neutral still-face expression. Infants’ orienting, communication, pointing toward source coded micro-analytically score (SCS) obtained by means principal component analysis. Results Infants equally oriented stimuli. All Exposure 80% exhibited any communication directed source, 48% showed at least one sound. Mothers who greater had higher probability showing no t = 2.14 ( p .035), or pointing, 1.93 .057). A significant negative linear association found between SCS months, R .07 .010), adjusting potential confounders. Conclusions This study suggests that might have increased altered development in as assessed through observational paradigm Special preventive attention should be devoted born pandemic.

Language: Английский

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Early life adversity across different cell- types in the brain

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 148, P. 105113 - 105113

Published: Feb. 28, 2023

Language: Английский

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Childhood adversity trajectories and weight status in young adult men: a register-based study including 359,783 Danish men

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(8), P. 1157 - 1163

Published: May 30, 2024

Childhood adversity has previously been associated with overweight and obesity in adult life, but there is a need for larger population-based studies using prospectively obtained trajectories across childhood to confirm these associations. Moreover, may also be underweight, which less often studied. The aim of the current study investigate association between from 0-15 years weight categories young men.

Language: Английский

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Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111960 - 111960

Published: July 5, 2024

Language: Английский

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