In search of convergent regional brain abnormality in cognitive emotion regulation: A transdiagnostic neuroimaging meta‐analysis DOI Creative Commons
Tina khodadadifar,

Zahra Soltaninejad,

Amir Ebneabbasi

et al.

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(4), P. 1309 - 1325

Published: Nov. 26, 2021

Abstract Ineffective use of adaptive cognitive strategies (e.g., reappraisal) to regulate emotional states is often reported in a wide variety psychiatric disorders, suggesting common characteristic across different diagnostic categories. However, the extent shared neurobiological impairments incompletely understood. This study, therefore, aimed identify transdiagnostic neural signature disturbed reappraisal using coordinate‐based meta‐analysis (CBMA) approach. Following best‐practice guidelines for conducting neuroimaging meta‐analyses, we systematically searched PubMed, ScienceDirect, and Web Science databases tracked references. Out 1,608 identified publications, 32 whole‐brain studies were retrieved that compared brain activation patients with disorders healthy controls during task. Then, peak coordinates group comparisons extracted several likelihood estimation (ALE) analyses performed at three hierarchical levels potential spatial convergence: global level (i.e., pooled analysis increased/decreased activations), experimental‐contrast grouped data based on regulation goal, stimulus valence, instruction rule) disorder‐group focused increasing homogeneity disorders). Surprisingly, none our provided significant convergent findings. CBMA indicates lack regional abnormality related task, probably due complex nature emotion regulation, heterogeneity clinical populations, and/or experimental statistical flexibility individual studies.

Language: Английский

Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Emotion Dysregulation Patients DOI Creative Commons
Luigi F. Saccaro, Farnaz Delavari, Ben Meuleman

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Characterizing the Effects of Age, Puberty, and Sex on Variability in Resting-State Functional Connectivity in Late Childhood and Early Adolescence DOI Creative Commons
Kelly A. Duffy, Andrea Wiglesworth, Donovan J. Roediger

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121238 - 121238

Published: April 1, 2025

Understanding the relative influences of age, pubertal development, and sex assigned at birth on brain development is a key priority developmental neuroscience given complex interplay these factors in onset psychopathology. Previous research has investigated how relate to static (time-averaged) functional connectivity (FC), but little known about their relationship with dynamic (time-varying) FC. The present study aimed investigate unique overlapping roles FC children aged approximately 9 14 ABCD Study using sample 5,122 low-motion resting-state scans (from 4,136 participants). Time-varying correlations frontolimbic, default mode, dorsal ventral corticostriatal networks, estimated Dynamic Conditional Correlations (DCC) method, were used calculate variability within- between-network graph theoretical measures segregation integration. We found decreased global efficiency across age range, increased within frontolimbic network driven primarily by those female (AFAB). AFAB youth specifically also showed several other networks. Controlling for both advanced being associated all segregation. These results potentially suggest maturation youth, particularly networks related psychopathology, lay foundation future investigations

Language: Английский

Citations

0
Deviations from normative functioning underlying emotional episodic memory revealed cross-scale neurodiverse alterations linked to affective symptoms in distinct psychiatric disorders DOI Creative Commons

Yang Xiao,

Mingzhu Li, Xiao Zhang

et al.

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100534 - 100534

Published: May 1, 2025

Language: Английский

Citations

0
Neural variability in three major psychiatric disorders DOI
Wei Wei,

Lihong Deng,

Chunxia Qiao

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 5217 - 5227

Published: July 13, 2023

Language: Английский

Citations

9
Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task DOI Creative Commons
Hannah S. Savage, Peter Mulders, Philip van Eijndhoven

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: July 20, 2024

Abstract Functional neuroimaging has contributed substantially to understanding brain function but is dominated by group analyses that index only a fraction of the variation in these data. It increasingly clear parsing underlying heterogeneity crucial understand individual differences and impact different task manipulations. We estimate large-scale ( N = 7728) normative models task-evoked activation during Emotional Face Matching Task, which enables us bind heterogeneous datasets common reference dissect group-level analyses. apply this model heterogenous patient cohort, map between patients with one or more mental health diagnoses relative cohort determine multivariate associations transdiagnostic symptom domains. For face>shapes contrast, have higher frequency extreme deviations are spatially heterogeneous. In for faces>baseline greater predictive value individuals’ functioning. Taken together, we demonstrate modelling fMRI task-activation can be used illustrate influence choices replicable differences, encourage its application other tasks future studies.

Language: Английский

Citations

3
Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity DOI Creative Commons
Raluca Petrican, Sidhant Chopra, Ashlea Segal

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, brain dynamics underlying this relationship are poorly understood. Here, address issue, we analyzed multimodal data from female participants in Adolescent Brain Cognitive Development (longitudinal, N = 441; aged 9–12 years) Human Connectome-Aging (cross-sectional, 130; 36–60 studies. Age-specific intrinsic functional network mediated link between perceptions of greater interpersonal adversity. The adolescent profile overlapped areas glutamatergic dopaminergic receptor density, middle-aged was concentrated visual, attentional default mode networks. two profiles showed opposite relationships with patterns neural variability cortical atrophy observed psychosis versus major depressive disorder. Our findings underscore divergent maturation senescence, which may explain developmentally specific vulnerabilities distinct disorders.

Language: Английский

Citations

0
Underlying biological mechanisms of emotion dysregulation in bipolar disorder DOI Creative Commons
Buse Beril Durdurak, Isabel Morales‐Muñoz, Angharad N. de Cates

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Difficulties with emotion regulation (ER) are a key feature of bipolar disorder (BD) contributing to poor psychosocial and functional outcomes. Abnormalities within processing thus provide targets for treatment strategies have implications response. Although biological mechanisms ER typically studied independently, emergent findings in BD research suggest that there important ties between the disturbances observed BD. Therefore, this narrative review, we an overview literature on underlying emotional dysregulation including genetic epigenetic mechanisms, neuroimaging findings, inflammation, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, neuroplasticity brain-derived neurotrophic factor (BDNF), circadian rhythm disturbances. Finally, discuss clinical relevance future directions research. The continued exploration ED may not only elucidate fundamental neurobiological but also foster advancements current development novel targeted treatments.

Language: Английский

Citations

0
Unpacking the functional heterogeneity of the Emotional Face Matching Task: a normative modelling approach DOI Creative Commons
Hannah S. Savage, Peter Mulders, Philip van Eijndhoven

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 27, 2023

Abstract Functional neuroimaging has contributed substantially to understanding brain function but is dominated by group analyses that index only a fraction of the variation in these data. It increasingly clear parsing underlying heterogeneity crucial understand individual differences and impact different task manipulations. We estimate large-scale (N=7728) normative models task-evoked activation during Emotional Face Matching Task, which enables us bind heterogeneous datasets common reference dissect group-level analyses. apply this model heterogenous patient cohort, map between patients with one or more mental health diagnoses relative cohort determine multivariate associations transdiagnostic symptom domains. For face>shapes contrast, have higher frequency extreme deviations are spatially heterogeneous. In for faces>baseline greater predictive value individuals’ functioning.

Language: Английский

Citations

7
Relation of resting brain signal variability to cognitive and socioemotional measures in an adult lifespan sample DOI Creative Commons

Cheryl L. Grady,

Jenny Rieck, Giulia Baracchini

et al.

Social Cognitive and Affective Neuroscience, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Abstract Temporal variability of the fMRI-derived blood-oxygen-level-dependent (BOLD) signal during cognitive tasks shows important associations with individual differences in age and performance. Less is known about relations between spontaneous BOLD measured at rest relatively stable measures, such as IQ or socioemotional function. Here, we examined among resting variability, cognitive/socioemotional scores from NIH Toolbox optimal time day for alertness (chronotype) a sample 157 adults 20 to 86 years age. To investigate these independently age, regressed out both behavioral scores. We hypothesized that greater would be related higher fluid cognition scores, more positive on scales morningness chronotype. Consistent this idea, found correlations (e.g. self-efficacy) morning chronotype, well negative emotional loneliness). Unexpectedly, cognition. These results suggest brain facilitates function characterizes those morning-type circadian rhythms, but individuals may likely show less temporal measures activity.

Language: Английский

Citations

7
The implication of a diversity of non-neuronal cells in disorders affecting brain networks DOI Creative Commons
Micaël Carrier,

Kira Dolhan,

Bianca Caroline Bobotis

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Nov. 11, 2022

In the central nervous system (CNS) neurons are classically considered functional unit of brain. Analysis physical connections and co-activation neurons, referred to as structural connectivity, respectively, is a metric used understand their interplay at higher level. A myriad glial cell types throughout brain composed microglia, astrocytes oligodendrocytes key players in maintenance regulation neuronal network dynamics. Microglia immune cells CNS, able affect populations number allowing for maturation plasticity CNS. part neurovascular unit, together they essential protect supply nutrients Oligodendrocytes known canonical role axonal myelination, but also contribute, with microglia astrocytes, CNS energy metabolism. Glial can achieve this variety roles because heterogeneous comprised different states. The neuroglial relationship be compromised various manners case pathologies affecting development consciousness mood. This review covers connectivity alterations schizophrenia, major depressive disorder, disorder consciousness, well correlation vascular connectivity. These networks further explored cellular scale by integrating diversity across explain how these affected pathology.

Language: Английский

Citations

11