An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 128, P. 110861 - 110861

Published: Sept. 9, 2023

There is a lot of evidence establishing that nervous system development related to the composition and functions gut microbiome. In addition, central (CNS) controls imbalance intestinal microbiota, constituting bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine neural circuits via vagal pathway. Several empirical data associated microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism Parkinson's other psychological disorders, like anxiety depression. Fecal transplantation (FMT) therapy has shown can transfer behavioral features recipient animals, which provides strong establish causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, demonstrated an important influence neurological disorders by synthesis neuroactive compounds interact regulation inflammatory processes. Further research needed demonstrate dysbiosis psychiatric how microbiota-based interventions may be used potential therapeutic tools.

Language: Английский

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Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 179, P. 106033 - 106033

Published: Feb. 8, 2023

Research in the last decade has unveiled a crucial role for trillions of microorganisms that reside gut influencing host neurodevelopment across lifespan via microbiota-gut-brain axis. Studies have linked alterations composition, complexity, and diversity microbiota to changes behaviour including abnormal social interactions, cognitive deficits, anxiety- depressive-like phenotypes. Moreover, been with neurodevelopmental, neuropsychiatric, neurodegenerative disorders. Interestingly, there appears be specific brain regions governing neurocircuitry driving higher function are susceptible influence from manipulations microbiome. This review will aim elucidate region-specific effects mediated by microbiota, focus on translational animal models some existing human neuroimaging data. Compelling preclinical evidence suggests disruption normal signalling can detrimental prefrontal cortex, amygdala, hippocampus, hypothalamus, striatum. Furthermore, studies mediating functional connectivity structure traced back neurocognition behavioural output. Understanding these microbiota-mediated aid identifying unique therapeutic targets treating neurological disorders associated regions.

Language: Английский

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The Role of Probiotics and Their Metabolites in the Treatment of Depression

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3213 - 3213

Published: April 4, 2023

Depression is a common and complex mental emotional disorder that causes disability, morbidity, quite often mortality around the world. closely related to several physical metabolic conditions causing depression. Studies have indicated there relationship between intestinal microbiota brain, known as gut–brain axis. While this microbiota–gut–brain connection disturbed, dysfunctions of immune system, endocrine gastrointestinal tract occur. Numerous studies show dysbiosis characterized by abnormal dysfunction axis could be direct cause disorders. Traditional treatment depression includes psychotherapy pharmacotherapy, it mainly targets brain. However, restoration functions via using probiotics, their metabolites, prebiotics, healthy diet may alleviate depressive symptoms. Administration probiotics labeled psychobiotics metabolites metabiotics, especially an adjuvant antidepressants, improves It new approach prevention, management, illnesses, particularly major For effectiveness antidepressant therapy, should administered at dose higher than 1 billion CFU/day for least 8 weeks.

Language: Английский

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Probiotics for the treatment of depression and its comorbidities: A systemic review

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 17, 2023

Depression is one of the most common psychiatric conditions, characterized by significant and persistent depressed mood diminished interest, often coexists with various comorbidities. The underlying mechanism depression remain elusive, evidenced lack an appreciate therapy. Recent abundant clinical trials animal studies support new notion that gut microbiota has emerged as a novel actor in pathophysiology depression, which partakes bidirectional communication between brain through neuroendocrine, nervous, immune signaling pathways, collectively known microbiota-gut-brain (MGB) axis. Alterations can trigger changes neurotransmitters, neuroinflammation, behaviors. With transition human microbiome research from studying associations to investigating mechanistic causality, MGB axis therapeutic target its These insights have fueled idea targeting on may open windows for efficient treatment Probiotics, live beneficial microorganisms, be used modulate dysbiosis into eubiosis modify occurrence development In present review, we summarize recent findings regarding discuss potential effects probiotics

Language: Английский

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Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3859 - 3859

Published: Sept. 4, 2023

Depressive disorders pose significant challenges to global public health, necessitating effective prevention and management strategies. Notably, the occurrence of suicide frequently coincides with depressive episodes. Suicide is as a paramount health concern that demands efficacious preventive Current psychiatric approaches heavily rely on pharmacological interventions but have had limited success in addressing burden mental issues. Suboptimal nutrition, its impact neuroendocrine system, has been implicated underlying pathology disorders. Folate, group water-soluble compounds, plays crucial role various central nervous system functions. Depressed individuals often exhibit low levels serum red blood cell folate. Multiple studies systematic reviews investigated efficacy folic acid derivative, L-methylfolate, which can cross blood–brain barrier, stand-alone or adjunct therapies for depression. Although findings mixed, available evidence generally supports use these compounds depressed individuals. Recent established links between one-carbon cycle, folate–homocysteine balance, immune function, glutamate excitation via NMDA (N-methyl-D-aspartate) receptors, gut microbiome eubiosis mood regulation. These provide insights into complex neurobiological mechanisms effects folate related Through comprehensive review existing literature, this study aims advance our understanding therapeutic potential depression treatment. It also seeks explore their suicidal tendencies shed light involved, leveraging latest discoveries research.

Language: Английский

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