Childhood Trauma Is Linked to Epigenetic Age Deceleration in Young Adults with Previous Youth Residential Care Placements DOI Open Access
Maria Meier,

Sina Kantelhardt,

Laura Gurri

et al.

Published: Aug. 3, 2023

Background. Early adversity increases the risk for mental and physical disorders as well premature death. Epigenetic processes, altered epigenetic aging in particular, might mediate these effects. While literature that examined links between early is growing, results have been heterogeneous. Objective. In current work, we explored link a sample of formerly out-of-home placed young adults.Method. A total N=117 adults (32% women, age mean=26.3 years, SD=3.6 years) with previous youth residential care placements completed Childhood Trauma Questionnaire (CTQ) Life Events Checklist (LEC-R) provided blood samples analysis DNA methylation using Illumina Infinium MethylationEPIC BeadChip Microarray. was estimated Hovarth’s Hannum’s clocks. Furthermore, residuals were calculated proxy by regressing on chronological age. The statistical plan preregistered (https://osf.io/b9ev8). Results. trauma negatively associated residuals, β = -.23, p .004 when controlling sex, BMI, smoking status proportional white cell type estimates. This association driven experiences neglect, -.25, .001. Lifetime exposure not significant predictor residuals. Conclusion. trauma, neglect decelerated our sample. More studies focusing institutionalized at-risk populations are needed to better understand which factors affect stress-related adaptations following traumatic experiences.

Language: Английский

Epigenetics of Ageing and Psychiatric Disorders DOI Creative Commons
Cezar-Ivan Coliță, Ion Udriștoiu,

Diana–Larisa Ancuta

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(1), P. 13 - 13

Published: Jan. 16, 2024

Both classic epigenetic modifications and microRNAs can impact a range of bodily processes, from metabolism to brain function, may contribute the development diseases such as cancer, cardiovascular disorders, psychiatric disorders. Numerous studies suggest connection between changes mood In this study, we performed comprehensive search using PubMed Google for terms "epigenetics", "ageing", "miRNA", "schizophrenia", "mood disorders" in titles abstracts articles. Epigenetic during early life play crucial role triggering severe mental disorders shaping their clinical trajectory. Although these alterations take place at any age, not be immediately evident or observable until later life. ageing process challenge prevailing belief that mutations are primary driver ageing. However, it is plausible consequence disorder rather than its root cause. Moreover, both influenced by shared environmental genetic factors. near future, might able replace chronological age with biological based on clock, promise providing greater therapeutic benefits. A wide drugs currently under various stages. full effectiveness yet realized, they show great potential treatment other complex diseases.

Language: Английский

Citations

6
The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health DOI
Zachary M. Harvanek, Marco P. Boks, Christiaan H. Vinkers

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 94(9), P. 694 - 705

Published: Feb. 9, 2023

Language: Английский

Citations

15
Epigenetic Aging in Major Depressive Disorder: Clocks, Mechanisms and Therapeutic Perspectives DOI
Muqtada Shaikh, Gaurav Doshi

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 978, P. 176757 - 176757

Published: June 17, 2024

Language: Английский

Citations

4
Adverse Childhood Experiences and Accelerated Epigenetic Aging in the Hispanic Community Health Study/Study of Latinos: Nativity as an Effect Modifier DOI
Yinxian Chen, Sarina Abrishamcar, Sheroi Johnson

et al.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 107369 - 107369

Published: Jan. 1, 2025

Language: Английский

Citations

0
Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder DOI Creative Commons

Ryota Shindo,

Takaki Tanifuji, Kenji Okazaki

et al.

npj Aging, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 6, 2023

Abstract Major depressive disorder (MDD) is known to cause significant disability. Genome-wide DNA methylation (DNAm) profiles can be used estimate biological aging and as epigenetic clocks. However, information on clocks reported in MDD patients inconsistent. Since antidepressants are likely confounders, we evaluated using various DNAm-based predictors with who had never received depression medication. A publicly available dataset consisting of whole blood samples from untreated ( n = 40) controls was used. We analyzed five (HorvathAge, HannumAge, SkinBloodAge, PhenoAge, GrimAge), telomere length (DNAmTL), age-related plasma proteins (GrimAge components), well white cell composition. The results indicate that were significantly associated acceleration HannumAge GrimAge. Furthermore, a decrease natural killer cells, based DNAm, observed MDD.

Language: Английский

Citations

10
The impact of COVID-19 on “biological aging” DOI Creative Commons

Fathima Humaira Amanullah,

Tanvir Alam, Nady El Hajj

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 10, 2024

The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age identified as key determinant for severe outcomes associated with infection. Epigenetic acceleration previously observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, comprehensive review this topic is still missing field. In review, we explore summarize research work focusing on biological aging markers, i.e., epigenetic telomere attrition COVID-19 patients. From reviewed articles, consistent pattern dysregulation shortened length, revealing attrition.

Language: Английский

Citations

3
Community and domestic violence are associated with DNA methylation GrimAge acceleration and heart rate variability in adolescents DOI Creative Commons
Nayara Cristina dos Santos Oliveira, Şeyma Katrinli, Simone Gonçalves de Assis

et al.

European journal of psychotraumatology, Journal Year: 2023, Volume and Issue: 14(2)

Published: May 5, 2023

Background: Cumulative exposure to violence can change the regulation of epigenetic and physiological markers. Although has been associated with accelerated cellular aging, little is known about associations cardiac autonomic activity.Objective: The current study aimed investigate relationship community domestic (CDV) vagal activity aging acceleration.Methods: A total 86 adolescents (57% female) were evaluated interviewed at two time-points in São Gonçalo (2014–2019), a Brazilian city high levels violence. Exposure CDV was assessed both time-points. GrimAge acceleration calculated from saliva DNA methylation using Infinium HumanMethylation450K (Illumina) collected first assessment. Heart rate variability (HRV) during stress tasks second assessment.Results: witnessed or directly experienced home increased significantly (t = 4.87, p < .01) across two-time points, males had reported higher 2.06, .043). Violence 1st assessment (B .039, value assessments HRV measured narration worst trauma (traumaHRV) .009, B .007, .024, 2nd respectively). traumaHRV .043, .049), 3D roller coaster video .061, .024).Conclusions: We found relevant evidence that experiencing adolescence stress-related activity. Understanding these factors this period could contribute development early interventions for health promotion.HIGHLIGHTS Higher Community acceleration.Higher activity.Exposure over time.

Language: Английский

Citations

7
Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging DOI
Sam K. Patterson, Rachel M. Petersen, Lauren J. N. Brent

et al.

Integrative and Comparative Biology, Journal Year: 2023, Volume and Issue: 63(3), P. 681 - 692

Published: June 5, 2023

Adverse experiences in early life are associated with aging-related disease risk and mortality across many species. In humans, confounding factors, as well the difficulty of directly measuring outcomes from birth till death, make it challenging to identify how adversity impacts aging health. These challenges can be mitigated, part, through study non-human animals, which exposed parallel forms age similarly humans. Furthermore, studying links between natural populations animals provides an excellent opportunity better understand social ecological pressures that shaped evolution sensitivities. Here, we highlight ongoing future research directions believe will most effectively contribute our understanding sensitivities their repercussions.

Language: Английский

Citations

7
Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements DOI Creative Commons
Maria Meier,

Sina Kantelhardt,

Laura Gurri

et al.

European journal of psychotraumatology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 25, 2024

Early adversity increases the risk for mental and physical disorders as well premature death. Epigenetic processes, altered epigenetic aging in particular, might mediate these effects. While literature that examined links between early is growing, results have been heterogeneous.

Language: Английский

Citations

2
Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing DOI Creative Commons
Vincenzo Iannuzzi, Nicolas Narboux‐Nême,

Andrea Lehoczki

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

In modern human societies, social interactions and pro-social behaviours are associated with better individual collective health, reduced mortality, increased longevity. Conversely, isolation is a predictor of shorter lifespan. The biological processes through which sociality affects the ageing process, as well healthspan lifespan, still poorly understood. Unveiling physiological, neurological, genomic, epigenomic, evolutionary mechanisms underlying association between longevity may open new perspectives to understand how lifespan determined in broader socio/evolutionary outlook. Here we summarize evidence showing dynamics can shape evolution life history traits physiological genetic directly or indirectly related We start by reviewing theories that incorporate into their model. Then, address link from two separate points view: (i) considering evidences comparative biology bioanthropology demonstrates contributes natural variation over course among different groups both pre-industrial post-industrial society, (ii) discussing main genetic, epigenetic molecular at interface ageing. highlight exposure chronic stressors deregulates neurophysiological immunological pathways promotes accelerated thereby reducing conclusion, describe intimately embedded biology, influencing healthy need foster interdisciplinary approaches including sciences, anthropology, ecology, physiology, genetics.

Language: Английский

Citations

2