Background.
Early
adversity
increases
the
risk
for
mental
and
physical
disorders
as
well
premature
death.
Epigenetic
processes,
altered
epigenetic
aging
in
particular,
might
mediate
these
effects.
While
literature
that
examined
links
between
early
is
growing,
results
have
been
heterogeneous.
Objective.
In
current
work,
we
explored
link
a
sample
of
formerly
out-of-home
placed
young
adults.Method.
A
total
N=117
adults
(32%
women,
age
mean=26.3
years,
SD=3.6
years)
with
previous
youth
residential
care
placements
completed
Childhood
Trauma
Questionnaire
(CTQ)
Life
Events
Checklist
(LEC-R)
provided
blood
samples
analysis
DNA
methylation
using
Illumina
Infinium
MethylationEPIC
BeadChip
Microarray.
was
estimated
Hovarth’s
Hannum’s
clocks.
Furthermore,
residuals
were
calculated
proxy
by
regressing
on
chronological
age.
The
statistical
plan
preregistered
(https://osf.io/b9ev8).
Results.
trauma
negatively
associated
residuals,
β
=
-.23,
p
.004
when
controlling
sex,
BMI,
smoking
status
proportional
white
cell
type
estimates.
This
association
driven
experiences
neglect,
-.25,
.001.
Lifetime
exposure
not
significant
predictor
residuals.
Conclusion.
trauma,
neglect
decelerated
our
sample.
More
studies
focusing
institutionalized
at-risk
populations
are
needed
to
better
understand
which
factors
affect
stress-related
adaptations
following
traumatic
experiences.
Psychiatry Research,
Journal Year:
2023,
Volume and Issue:
327, P. 115373 - 115373
Published: July 26, 2023
Bipolar
disorder
(BD)
is
a
chronic
and
severe
psychiatric
associated
with
significant
medical
morbidity
reduced
life
expectancy.
In
this
study,
we
assessed
accelerated
epigenetic
aging
in
individuals
BD
using
various
DNA
methylation
(DNAm)-based
markers.
For
purpose,
used
five
clocks
(Horvath,
Hannum,
EN,
PhenoAge,
GrimAge)
DNAm-based
telomere
length
clock
(DNAmTL).
DNAm
profiles
were
obtained
Infinium
MethylationEPIC
Arrays
from
whole-blood
samples
of
184
BD.
We
also
estimated
blood
cell
counts
based
on
levels
for
adjustment.
Significant
correlations
between
chronological
age
each
the
six
different
observed.
Following
adjustment
counts,
found
that
AgeAccels
(age
accelerations)
significantly
body
mass
index.
GrimAge
AgeAccel
was
male
sex,
smoking
status
childhood
maltreatment.
DNAmTL
status.
Overall,
study
showed
distinct
are
sensitive
to
aspects
process
Further
investigations
comprehensive
analyses
large
required
confirm
our
findings
potential
determinants
an
Aging,
Journal Year:
2024,
Volume and Issue:
unknown, P. 119 - 145
Published: Jan. 1, 2024
Starting
already
several
weeks
after
gestation,
our
immune
system
interacts
with
the
body's
environment
and
develops
into
a
complex
finely
tuned
network
of
highly
specialized
cells,
tissues,
organs
proteins
that
eliminate
pathogens
as
well
damaged,
degenerated,
senescent
cells.
Both
development
maintenance
these
functions
over
lifespan
are
essential
for
conserving
body
functions,
overcoming
infections,
suppressing
cancer.
However,
biological
aging,
changes
arise
in
architecture
responses
system,
process
together
manifestation
lingering
level
low-grade
inflammation
is
termed
"immunosenescence."
In
this
chapter,
rise
fall
aging
discussed
an
overview
biomolecular
mechanisms
along
upstream
risk
factors
amplifying
process,
provided
to
benefit
interventions
prevent,
attenuate,
or
even
reverse
immunosenescence.
Journal of Educational Health and Community Psychology,
Journal Year:
2024,
Volume and Issue:
13(1), P. 201 - 201
Published: March 22, 2024
Parental
incarceration
has
a
significant
impact
on
children,
so
resiliency
is
the
essential
thing
that
needs
to
be
owned
minimize
this
impact.
However,
research
matter
still
very
limited.
This
scoping
review
aims
explore
and
resilience
of
children
with
incarcerated
parents.
PRISMA
five
databases
(Scopus,
ScienceDirect,
EBSCOhost,
Semantic
Scholar,
Springer)
were
used
in
study.
There
ten
articles
met
inclusion
criteria.
The
results
have
shown
parental
leads
mental
health
problems,
behavior
decreased
academic
performance,
family
dysfunction,
financial
hardship.
Social
support
children's
involvement
positive
activities
will
help
process.
Future
can
focus
dynamics
by
considering
stages
development
cultural
context,
as
well
its
relation
preventive,
intervention,
rehabilitation
efforts
for
parents,
especially
Indonesia.
Psychological Medicine,
Journal Year:
2024,
Volume and Issue:
54(12), P. 3398 - 3406
Published: Sept. 1, 2024
Abstract
Background
Cross-sectional
studies
have
identified
health
risks
associated
with
epigenetic
aging.
However,
it
is
unclear
whether
these
make
clocks
‘tick
faster’
(i.e.
accelerate
biological
aging).
The
current
study
examines
concurrent
and
lagged
within-person
changes
of
a
variety
Methods
Individuals
from
the
Great
Smoky
Mountains
Study
were
followed
age
9
to
35
years.
DNA
methylation
profiles
assessed
blood,
at
multiple
timepoints
waves)
for
each
individual.
Health
psychiatric,
lifestyle,
adversity
factors.
Concurrent
(
N
=
539
individuals;
1029
assessments)
380
760
analyses
used
determine
link
between
Results
models
showed
that
BMI
r
0.15,
P
FDR
<
0.01)
was
significantly
correlated
aging
subject-level
but
not
wave-level.
Lagged
demonstrated
depressive
symptoms
b
1.67
months
per
symptom,
0.02)
in
adolescence
accelerated
adulthood,
also
when
fully
adjusted
BMI,
smoking,
cannabis
alcohol
use.
Conclusions
Within-persons,
unaccompanied
by
aging,
suggesting
unlikely
immediately
‘accelerate’
time
indicated
childhood/adolescence
predicted
adulthood.
Together,
findings
suggest
age-related
embedding
instant
provides
prognostic
opportunities.
Repeated
measurements
longer
follow-up
times
are
needed
examine
stable
dynamic
contributions
childhood
experiences
across
lifespan.
Journal of Social and Personal Relationships,
Journal Year:
2024,
Volume and Issue:
41(8), P. 2169 - 2191
Published: March 4, 2024
Childhood
maltreatment
influences
adult
physical
health
through
cascading
effects
over
the
life
course
and
it
is
critical
to
identify
intervening
processes.
Marital
quality
has
significant
implications
for
via
cognitive,
emotional,
behavioral
pathways
may
be
a
viable
pathway.
Given
that
cardiometabolic
biomarkers
are
associated
with
leading
causes
of
death
in
United
States,
current
study
longitudinally
investigated
marital
quality,
locus
control,
eating
habits
serial
mediation
model
linking
childhood
high
density
lipoprotein
(HDL)
low
(LDL).
Using
sample
352
adults
from
Midlife
Development
we
used
three
waves
data
test
our
hypotheses.
Results
structural
equation
models
indicate
although
all
hypothesized
direct
were
statistically
significant,
indirect
non-significant.
was
lower
marriage,
higher
levels
control
which,
turn,
healthier
habits.
Finally,
greater
HDL,
but
not
LDL.
Additionally,
exerted
effect
on
LDL
mediated
relationship
between
LDL,
HDL.
For
researchers,
appears
mechanism
biomarkers,
yet
do
appear
have
strong
effects.
clinicians,
strengthening
couple
among
survivors
promotive
time.
Biological Psychiatry Global Open Science,
Journal Year:
2024,
Volume and Issue:
4(5), P. 100341 - 100341
Published: June 3, 2024
Childhood
maltreatment
and
psychiatric
morbidity
have
each
been
associated
with
accelerated
biological
aging
primarily
through
cross-sectional
studies.
Using
data
from
a
prospective
longitudinal
study
of
individuals
histories
childhood
controls
followed
up
into
midlife,
we
test
two
hypotheses
examining
whether
(1)
symptoms
mediate
the
relationship
between
(2)
anxiety,
depression,
or
post-traumatic
stress
disorder
act
in
conjunction
to
exacerbate
association
child
aging.
Children
(ages
0-11y)
documented
demographically
matched
were
adulthood
(N
=
607)
interviewed
over
several
waves
study.
Depression,
assessed
at
mean
ages
29
(interview
1)
40
2).
Biological
age
was
measured
blood-chemistries
collected
later
(Mage=
41y)
using
Klemera-Doubal
method.
Hypotheses
tested
linear
regressions
path
analyses.
Adults
showed
more
PTSD,
anxiety
both
interviews
advanced
aging,
compared
controls.
PTSD
depression
only
interview
2
predicted
There
no
evidence
mediation;
however,
moderated
These
new
findings
reveal
shorter
longer-term
impact
on
amplifying
effect
