Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
206, P. 107300 - 107300
Published: July 9, 2024
Depression
is
a
serious
global
mental
disorder.
Numerous
studies
have
found
that
depression
may
be
closely
related
to
decreased
neurogenesis,
neuroinflammation,
neurotransmitter
imbalance,
and
synaptic
plasticity
dysfunction.
The
pathogenesis
of
complex
involves
multiple
signal
transduction
pathways
molecular
changes.
PI3K/AKT
pathway
an
essential
signaling
in
neurons,
which
widely
expressed
emotion-related
regions
the
brain.
Therefore,
play
moderating
role
mood
disorders.
However,
mechanism
not
been
fully
described.
This
review
systematically
summarized
discussed
its
potential
treatment
depression.
will
help
development
antidepressants.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 5, 2024
Background:
Alchornea
laxiflora
(Benth.)
Pax
&
K.
Hoffm.
(A.
laxiflora)
has
been
indicated
in
traditional
medicine
to
treat
depression.
However,
scientific
rationalization
is
still
lacking.
Hence,
this
study
aimed
investigate
the
antidepressant
potential
of
A.
using
network
pharmacology
and
molecular
docking
analysis.
Materials
methods:
The
active
compounds
targets
depression-related
were
retrieved
from
public
databases,
such
as
PubMed,
PubChem,
DisGeNET,
GeneCards,
OMIM,
SwissTargetprediction,
BindingDB,
STRING,
DAVID.
Essential
bioactive
compounds,
targets,
signaling
pathways
predicted
silico
analysis,
including
BA-TAR,
PPI,
BA-TAR-PATH
construction,
GO
KEGG
pathway
enrichment
Later
on,
with
interaction
essential
core
depression
verified.
Results:
approach
identified
15
a
total
219
compound-related
14,574
200
intersecting
between
them.
SRC,
EGFR,
PIK3R1,
AKT1,
MAPK1
whereas
3-acetyloleanolic
acid
3-acetylursolic
most
anti-depressant
potential.
functional
analysis
revealed
129
terms,
82
biological
processes,
14
cellular
components,
34
function
terms.
yielded
significantly
enriched
108
pathways.
Out
them,
PI3K-Akt
MAPK
might
have
key
role
treating
Molecular
results
exhibited
that
depression,
MAPK1,
bind
stably
analyzed
laxiflora.
Conclusion:
present
elucidates
pertinent
mechanism
action
.
exert
an
effect
by
regulating
further
investigations
are
required
validate.
Environment International,
Journal Year:
2024,
Volume and Issue:
194, P. 108883 - 108883
Published: July 20, 2024
Particulate
matter
(PM)
has
always
received
widespread
attention,
PM2.5
pollution
is
associated
with
many
adverse
effects,
including
cardiovascular,
respiratory
and
metabolic
diseases
mood
disorders.
However,
the
underlying
mechanisms
are
not
yet
clear.
In
this
study,
small
animal
whole
body
inhalation
exposure
system
collected
real-time
in
real
environment,
which
can
truly
reflect
presence
status
of
atmospheric
environment.
This
study
investigated
depressive
like
behavior
mice
exposed
to
for
a
long
time
proved
its
molecular
mechanism
through
RNA-seq.
C57BL/6
male
were
ambient
air
together
control
mice,
who
breathed
filtered
high-efficiency
particulate
filters.
Depression
was
observed
PM
4,
6,
8
weeks
behavioral
experiments,
EEG
signals,
pathological
sections.
RNA-seq
results
indicated
that
might
be
related
pro-inflammatory
anti-inflammatory
cytokines,
as
well
BDNF
pathways
hippocampus
olfactory
bulb.
suggests
may
induce
depression
MAPK/CREB/BDNF
pathway.
Atmospheric
been
classified
Class
1
pollutant
by
International
Agency
Research
on
Cancer.
Current
research
mainly
believed
seriously
affected
lung
health,
but
there
little
effects
other
organs.
With
improvement
quality
life,
people
paying
more
attention
mental
while
brain.
simulated
environment
explored
brain
provided
solid
scientific
basis
inducing
after
exposure.
Oxford University Press eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 857 - 894
Published: Jan. 1, 2025
Abstract
This
chapter
describes
how
stress
affects
the
hippocampus
across
biological
scales.
The
discovery
of
hormone
receptors
in
provided
a
gateway
into
studying
structural
and
functional
plasticity
developing,
adult,
aging
hippocampus.
same
framework
has
been
utilized
for
studies
other
brain
areas
that
interact
with
context
effects
on
brain,
such
as
amygdala
prefrontal
cortex.
It
also
outlines
findings
have
broadened
definition
to
include
epigenetic
factors,
immune
system
mediators,
sex
metabolic
hormones,
determine
body
each
other.
discusses
concepts
allostasis
allostatic
load
adaptations
changing
environment,
health-promoting
health-damaging
behaviors.
Frontiers in Neurology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 10, 2025
This
bibliometric
study
systematically
analyzes
the
research
landscape
of
electroacupuncture
(EA),
focusing
on
its
applications
in
pain
relief
and
emotional
regulation
from
2014
to
2024.
EA,
a
contemporary
adaptation
traditional
acupuncture,
has
gained
significant
attention
for
potential
therapeutic
benefits
managing
chronic
mood
disorders.
Using
Web
Science
Core
Collection
as
primary
data
source,
we
identified
537
articles
related
EA's
effects.
The
analysis
was
conducted
using
tools
such
VOSviewer
CiteSpace
visualize
publication
trends,
hotspots,
collaborative
networks.
highlights
upward
trend
output,
with
marked
increase
publications
2019
onwards.
China
emerged
leading
contributor,
accounting
over
60%
total
followed
by
United
States
South
Korea.
Key
institutions,
Zhejiang
Chinese
Medical
University
Shanghai
Traditional
Medicine,
have
made
substantial
contributions,
emphasizing
importance
medicine
this
area.
Major
themes
include
modulation
neurotransmitter
systems,
role
endogenous
opioids,
impact
EA
Collaborative
networks
between
countries
institutions
are
mapped,
revealing
centrality
American
partnerships.
comprehensive
outlines
current
state
identifies
gaps
opportunities
future
studies,
particularly
understanding
mechanistic
pathways
integration
into
mainstream
medical
practices.
findings
provide
roadmap
enhancing
underscore
complex
conditions
involving
both
physical
components.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: March 10, 2025
Depression
is
a
well-known
risk
factor
for
tumors,
but
the
mechanisms
other
than
inflammation
are
unclear.
Aerobic
glycolysis
considered
to
be
critical
element
in
reprogramming
of
energy
metabolism
malignant
and
impaired
has
been
reported
brains
chronic
stress
mice.
Therefore,
this
study
aimed
explore
role
which
depression
promotes
tumorigenesis.
We
examined
impacts
unpredictable
mild
(CUMS)
on
growth
metastasis
breast
cancer
(BC)
lung
(LC).
CUMS
was
used
construct
mouse
model,
BALB/c
mice
were
injected
with
4T1-Luc
cells
right
subcutaneous
mammary
fat
pad,
C57BL/6
Lewis-Luc
tail
vein.
The
experiments
conducted
through
behavioral
experiments,
live
imaging
techniques
small
animals,
Western
blot,
Glycolytic
metabolites
measurement,
Hematoxylin
eosin
staining
(H&E
staining),
Nissl
staining,
immunohistochemical
(IHC)
tests.
findings
showed
that
both
tumors
induced
depressive-like
behavior,
neuronal
damage,
synaptic
plasticity
mice,
while
also
enhanced
tumor
development
BC
LC.
In
brain,
alone
combination
less
influence
glycolytic
products
enzyme
levels.
However,
significantly
levels
aerobic
enzymes
tissue.
Collectively,
our
results
provide
insights
into
how
regulated
leading
depression-like
depression,
turn,
promoted
