Galactooligosaccharides Attenuate Behavioural, Haematological and Immunological Abnormalities and Influence Gut Microbiota in Rats with Amygdala Hyperactivation Induced by Electrical Stimulation DOI Open Access
Jan Ruciński, E. Kurowska, Dorota Myślińska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4353 - 4353

Published: May 3, 2025

The amygdala, especially its central nucleus (CeA), is one of the key brain structures regulating fear, anxiety and stress responses also involved in gut microbiota signal processing. Amygdala hyperactivity, as well alterations, plays an important role pathophysiology disorders, depression or post-traumatic disorder (PTSD). present study determines whether 3 weeks galactooligosaccharide (GOS) supplementation alleviates behavioural, haematological, immunological disturbances induced by long-term electrical stimulation CeA rats (Stim). unsupplemented Stim group showed locomotor hyperactivity higher (measured with actometer elevated plus maze, respectively), a decrease white blood cells (WBCs), lymphocytes (LYMs), red (RBCs) platelets (PLTs); elevation TNFα; reduction IL-10 concentration plasma; alterations compared to control (Sham) group. GOS alleviated all these Stim-induced adverse effects even normalised them sham level. effect was comparable citalopram more effective WBC PLT normalisation induction. obtained results indicate high therapeutic potential stress-related disorders. may support conventional therapy prevention PTSD,

Language: Английский

Galactooligosaccharides Attenuate Behavioural, Haematological and Immunological Abnormalities and Influence Gut Microbiota in Rats with Amygdala Hyperactivation Induced by Electrical Stimulation DOI Open Access
Jan Ruciński, E. Kurowska, Dorota Myślińska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4353 - 4353

Published: May 3, 2025

The amygdala, especially its central nucleus (CeA), is one of the key brain structures regulating fear, anxiety and stress responses also involved in gut microbiota signal processing. Amygdala hyperactivity, as well alterations, plays an important role pathophysiology disorders, depression or post-traumatic disorder (PTSD). present study determines whether 3 weeks galactooligosaccharide (GOS) supplementation alleviates behavioural, haematological, immunological disturbances induced by long-term electrical stimulation CeA rats (Stim). unsupplemented Stim group showed locomotor hyperactivity higher (measured with actometer elevated plus maze, respectively), a decrease white blood cells (WBCs), lymphocytes (LYMs), red (RBCs) platelets (PLTs); elevation TNFα; reduction IL-10 concentration plasma; alterations compared to control (Sham) group. GOS alleviated all these Stim-induced adverse effects even normalised them sham level. effect was comparable citalopram more effective WBC PLT normalisation induction. obtained results indicate high therapeutic potential stress-related disorders. may support conventional therapy prevention PTSD,

Language: Английский

Citations

0