Prenatal Exposure To Valproic Acid Induces Increased Autism-Like Behaviors and Impairment of Learning and Memory Functions in Rat Offspring by Upregulating ADAM10 Expression DOI Creative Commons
Jingyuan Yang, Xiaoli Li,

Jing Tan

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(3)

Published: April 17, 2025

Autism spectrum disorder (ASD) involves a complex neurodevelopmental pathogenesis. A disintegrin and metalloproteinase 10 (ADAM10) plays crucial role in embryonic brain development neural network stability. This study aimed to investigate the influence of ADAM10 on excitation/inhibition (E/I) balance, autism-like behaviors, learning memory dysfunction rats prenatally exposed valproic acid (VPA) determine potential intervention strategies. The VPA-exposed group exhibited increased levels secreted amyloid precursor protein-α (sAPPα). Moreover, overexpression glutamate decarboxylase 1 N-methyl-D-aspartate receptors was observed. High-performance liquid chromatography-mass spectrometry revealed elevated glutamate, glutamine, γ-aminobutyric acid, as well an E/I imbalance VPA group. Additionally, narrower synaptic clefts postsynaptic density vesicles were Remarkably, intraperitoneal administration inhibitor during critical period significantly improved ASD-like behavior function rats. effectively reduced abnormally high sAPPα prefrontal cortex corrected abnormal balance. Thus, inhibiting may improve imbalance, alleviate core symptoms ASD, dysfunction. use represents therapeutic strategy for treating ASD patients with intellectual disabilities.

Language: Английский

Prenatal Exposure To Valproic Acid Induces Increased Autism-Like Behaviors and Impairment of Learning and Memory Functions in Rat Offspring by Upregulating ADAM10 Expression DOI Creative Commons
Jingyuan Yang, Xiaoli Li,

Jing Tan

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(3)

Published: April 17, 2025

Autism spectrum disorder (ASD) involves a complex neurodevelopmental pathogenesis. A disintegrin and metalloproteinase 10 (ADAM10) plays crucial role in embryonic brain development neural network stability. This study aimed to investigate the influence of ADAM10 on excitation/inhibition (E/I) balance, autism-like behaviors, learning memory dysfunction rats prenatally exposed valproic acid (VPA) determine potential intervention strategies. The VPA-exposed group exhibited increased levels secreted amyloid precursor protein-α (sAPPα). Moreover, overexpression glutamate decarboxylase 1 N-methyl-D-aspartate receptors was observed. High-performance liquid chromatography-mass spectrometry revealed elevated glutamate, glutamine, γ-aminobutyric acid, as well an E/I imbalance VPA group. Additionally, narrower synaptic clefts postsynaptic density vesicles were Remarkably, intraperitoneal administration inhibitor during critical period significantly improved ASD-like behavior function rats. effectively reduced abnormally high sAPPα prefrontal cortex corrected abnormal balance. Thus, inhibiting may improve imbalance, alleviate core symptoms ASD, dysfunction. use represents therapeutic strategy for treating ASD patients with intellectual disabilities.

Language: Английский

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