Gut microbiome links obesity to type 2 diabetes: insights from Mendelian randomization DOI Creative Commons
Li Fu, Ancha Baranova, Hongbao Cao

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 27, 2025

Research has established links between the gut microbiome (GM) and both obesity type 2 diabetes (T2D), which is much discussed, but underexplored. This study employed body mass index (BMI) as measurement of to delve deeper into correlations from a genetic perspective. We performed Mendelian randomization (MR) analysis examine causal effects GM on T2D BMI, vice versa. Genome-wide association (GWAS) summary datasets were utilized for analysis, including (N = 933,970), BMI 806,834), two international consortium MiBioGen (211 taxa, N 18,340) Dutch Microbiome Project (DMP) (207 7,738). These mainly cover European populations, with additional cohorts Asia other regions. To further explore potential mediating role in connections T2D, their interaction patterns summarized network. MR identified 9 taxa that showed protective properties against T2D. Seven species within Firmicutes Bacteroidales phyla DMP, (Odds Ratio (OR): 0.94-0.95). Conversely, components contributing abundance 12 associated increased risks (OR: 1.04-1.12). Furthermore, may elevate seven 1.03-1.08) reduce six 0.93-0.97). In influence component composition, affected 52 bacterial 28 decreasing 0.75-0.92) 24 increasing 1.08-1.27). Besides, abundances 25 negatively correlated 0.95-0.99), while positive detected 14 1.01-1.05). Notably, we uncovered 11 genetically formed an interactive Our findings provide evidence GM-mediated The identification relevant offers valuable insights these diseases.

Language: Английский

Unraveling the genetic links between depression and type 2 diabetes DOI
Ancha Baranova, Dongming Liu,

Vikas Chandhoke

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111258 - 111258

Published: Jan. 19, 2025

Language: Английский

Citations

2
Relationship of Depression and Asthma: A Observational and Mendelian randomization study DOI

Shiyuan Guo,

Yilong Lin, Junting Li

et al.

Journal of Asthma, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 5, 2025

Background

Language: Английский

Citations

0
Causal associations between posttraumatic stress disorder and type 2 diabetes DOI Creative Commons
Yuqing Song, Ancha Baranova, Hongbao Cao

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 19, 2025

Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of is still not known. We used GWAS data from European ancestry (23,121 cases and 151,447 controls) T2D (80,154 853,816 to investigate bidirectional associations between by Mendelian randomization (MR) analysis. showed that was causally associated higher odds (OR = 1.04, 95% CI: 1.01–1.06, P 0.0086), but vice versa. Our study suggests may increase T2D. sufferers should be screened for its precursor known as metabolic syndrome.

Language: Английский

Citations

0
Evaluating the causal effects of circulating metabolic biomarkers on Alzheimer's disease DOI
Jianbin Du, Ancha Baranova, Hongbao Cao

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 138, P. 111309 - 111309

Published: March 2, 2025

Language: Английский

Citations

0
Opposite causal effects of type 2 diabetes and metformin on Alzheimer's disease DOI Creative Commons
Dongming Liu, Hongbao Cao, Ancha Baranova

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100129 - 100129

Published: March 1, 2025

Type 2 diabetes (T2D) is commonly co-morbid with Alzheimer's disease (AD). However, it remains unclear whether T2D itself or the antidiabetic drug metformin contributes to progression of AD. This study aimed investigate overall and independent effects use on risk Summary genome-wide association datasets were utilized for Mendelian randomization (MR) multivariable MR (MVMR) analyses, including ones (N = 455,017), 456,276), AD 453,733). Additionally, using proportional imbalance method, we analyzed AD-related adverse events in FDA Adverse Event Reporting System (FAERS) database (covering Q1 2004 Q2 2024). Our two-sample analysis indicated that not associated (OR: 1.03, CI: 0.99-1.08, P 0.128). while statistically significant, genetic signature exposure demonstrated a trend toward an increased 1.05, 1.00-1.09, 0.053). Interestingly, MVMR analysis, which evaluates T2D, found robust decrease 0.82, 0.68-0.98, 0.031), was higher 1.26, 1.06-1.50, 9.45E-3). In FAERS database, total 228,283 metformin-related event reports from 67,742 cases found. For as target event, signal reported 29 (ROR: 0.83, 95 % 0.58-1.19, 0.3126). reveals opposite causal These findings highlight importance assessing when prescribing patients T2D.

Language: Английский

Citations

0
Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota DOI
Xiang Li, Xiaojun Wang,

Linping Zhu

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Gut microbiome links obesity to type 2 diabetes: insights from Mendelian randomization DOI Creative Commons
Li Fu, Ancha Baranova, Hongbao Cao

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 27, 2025

Research has established links between the gut microbiome (GM) and both obesity type 2 diabetes (T2D), which is much discussed, but underexplored. This study employed body mass index (BMI) as measurement of to delve deeper into correlations from a genetic perspective. We performed Mendelian randomization (MR) analysis examine causal effects GM on T2D BMI, vice versa. Genome-wide association (GWAS) summary datasets were utilized for analysis, including (N = 933,970), BMI 806,834), two international consortium MiBioGen (211 taxa, N 18,340) Dutch Microbiome Project (DMP) (207 7,738). These mainly cover European populations, with additional cohorts Asia other regions. To further explore potential mediating role in connections T2D, their interaction patterns summarized network. MR identified 9 taxa that showed protective properties against T2D. Seven species within Firmicutes Bacteroidales phyla DMP, (Odds Ratio (OR): 0.94-0.95). Conversely, components contributing abundance 12 associated increased risks (OR: 1.04-1.12). Furthermore, may elevate seven 1.03-1.08) reduce six 0.93-0.97). In influence component composition, affected 52 bacterial 28 decreasing 0.75-0.92) 24 increasing 1.08-1.27). Besides, abundances 25 negatively correlated 0.95-0.99), while positive detected 14 1.01-1.05). Notably, we uncovered 11 genetically formed an interactive Our findings provide evidence GM-mediated The identification relevant offers valuable insights these diseases.

Language: Английский

Citations

0