Genetic neurocognitive profile of autism unveiled with gene transcription DOI Creative Commons

Yingxing Zhang,

Fangfang Li,

Hongli Wu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106925 - 106925

Published: April 1, 2025

How neurocognitive processes elaborate phenotypic heterogeneity within autism spectrum disorder (ASD) remains unknown. Applying the principal component analysis to Neurosynth database, we established profiles characterize of ASD, revealing a cortical hierarchical axis that separates temporal cortex from other networks. By integrating with transcriptomic data, found gene sets shaping patterns are enriched in ASD-related biological and ASD pathogenic risk. Using data-driven approach, identified topographic network for comprising temporal, frontal, somatosensory, visual cortices, its signatures differentiating between regions over neurodevelopment. Additionally, functional reorganization has occurred as central node. Collectively, our results reveal spatially covarying profiles, emphasizing influence underlying genetic mechanism on ASD.

Language: Английский

Genetic neurocognitive profile of autism unveiled with gene transcription DOI Creative Commons

Yingxing Zhang,

Fangfang Li,

Hongli Wu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106925 - 106925

Published: April 1, 2025

How neurocognitive processes elaborate phenotypic heterogeneity within autism spectrum disorder (ASD) remains unknown. Applying the principal component analysis to Neurosynth database, we established profiles characterize of ASD, revealing a cortical hierarchical axis that separates temporal cortex from other networks. By integrating with transcriptomic data, found gene sets shaping patterns are enriched in ASD-related biological and ASD pathogenic risk. Using data-driven approach, identified topographic network for comprising temporal, frontal, somatosensory, visual cortices, its signatures differentiating between regions over neurodevelopment. Additionally, functional reorganization has occurred as central node. Collectively, our results reveal spatially covarying profiles, emphasizing influence underlying genetic mechanism on ASD.

Language: Английский

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