Curcumin as a Potential Treatment for COVID-19

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: May 7, 2021

Coronavirus disease 2019 (COVID-19) is an infectious that rapidly spread throughout the world leading to high mortality rates. Despite knowledge of previous diseases caused by viruses same family, such as MERS and SARS-CoV, management treatment patients with COVID-19 a challenge. One best strategies around help combat has been directed drug repositioning; however, these drugs are not specific this new virus. Additionally, pathophysiology highly heterogeneous, way SARS-CoV-2 modulates different systems in host remains unidentified, despite recent discoveries. This complex multifactorial response requires comprehensive therapeutic approach, enabling integration refinement responses given single compound several action potentials. In context, natural compounds, Curcumin, have shown beneficial effects on progression inflammatory due its numerous mechanisms: antiviral, anti-inflammatory, anticoagulant, antiplatelet, cytoprotective. These many other curcumin make it promising target adjuvant COVID-19. Hence, purpose review specifically point out how could interfere at times/points during infection SARS-CoV-2, providing substantial contribution therapy for

Language: Английский

---

Muscarinic Receptor Activators as Novel Treatments for Schizophrenia

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(8), P. 627 - 637

Published: March 25, 2024

Achieving optimal treatment outcomes for individuals living with schizophrenia remains challenging, despite 70 years of drug development efforts. Many chemically distinct antipsychotics have been developed over the past seven decades improved safety and tolerability but only slight variation in efficacy. All currently prescribed act as antagonists or partial agonists at dopamine D2 receptor. With a few possible exceptions, antipsychotic drugs similar modest efficacy treating positive symptoms are relatively ineffective addressing negative cognitive disease. The novel treatments focused on targeting muscarinic acetylcholine receptors (mAChRs) has interest more than 25 following reports that dual M1/M4 preferring mAChR agonist resulted antipsychotic-like effects procognitive properties Alzheimer's disease schizophrenia; recent clinical trials confirmed these findings. In addition, advances our understanding receptor binding activation xanomeline specific mAChRs potential to inform future design mAChRs.

Language: Английский

---

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

Annals of Diagnostic Pathology, Journal Year: 2020, Volume and Issue: 51, P. 151682 - 151682

Published: Dec. 24, 2020

Language: Английский

---

Toxicological effects of cigarette butts for marine organisms

Environment International, Journal Year: 2023, Volume and Issue: 171, P. 107733 - 107733

Published: Jan. 1, 2023

Cigarette butts (CBs), one of the most common litter items found on beaches, represent a still unexplored environmental hazard. This study aimed at multidisciplinary characterization their toxicological risks marine organisms integrating chemical analyses released compounds with wide panel biological responses, such as ecotoxicological bioassays species different trophic positions, molecular responses in an ex vivo model (Precision-Cut Tissue Slices, PCTS mussels digestive glands), bioavailability and cellular biomarkers exposed to CBs laboratory experiments. Trace metals, aliphatic polycyclic aromatic hydrocarbons, nicotine cotinine were artificial seawater after 24 h which determined significant inhibition bacterial bioluminescence, oyster embryo development growth algal species. Modulation peroxisomal proliferation antioxidant gene expression was observed PCTS, while exposure accumulation chemicals alterations immune system, neurotoxic genotoxic damage. Using quantitative Weight Evidence model, environment summarized, highlighting importance analyses, batteries bioassays, assess impact these hazardous materials environment.

Language: Английский

---

Theory, Technology and Practice of Unconventional Petroleum Geology

Journal of Earth Science, Journal Year: 2023, Volume and Issue: 34(4), P. 951 - 965

Published: Aug. 1, 2023

Language: Английский

---

Neurotropic Viruses, Astrocytes, and COVID-19

Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: April 9, 2021

At the end of 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was discovered in China, causing a new disease, termed COVID-19 by WHO on February 11, 2020. time this paper (January 31, 2021), more than 100 million cases have been recorded, which claimed over lives worldwide. The most important clinical presentation is pneumonia; however, many patients present various neurological symptoms, ranging from loss olfaction, nausea, dizziness, and headache to encephalopathy stroke, with high prevalence inflammatory central nervous system (CNS) syndromes. SARS-CoV-2 may also target center brainstem cause silent hypoxemia. However, neurotropic mechanism(s) affects CNS remain(s) unclear. In paper, we first address involvement astrocytes then elucidate knowledge as virus well several other flaviviruses (with particular emphasis West Nile virus, tick-borne encephalitis Zika virus) highlight mechanisms that astroglial cells CNS. These key homeostasis-providing exhibit functions act favorable milieu for replication possibly environment well. role pathology, related aging neurodegenerative disorders, environmental factors, discussed. Understanding these better understanding pathophysiology developing strategies mitigate manifestations COVID-19.

Language: Английский

---

Potency, Safety, and Pharmacokinetic Profiles of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Feb. 1, 2021

Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the ongoing COVID-19 pandemic. The main protease or 3C-like (M pro 3CL ) of SARS-CoV-2 is considered an important target formulate potent corresponding its crucial role in virus replication maturation addition relatively conserved active site. Promising baseline data on potency safety targeting M currently available. However, preclinical clinical pharmacokinetic profiles these very limited. This review discusses potency, safety, potential inhibitors forward directions development future studies focusing therapeutics.

Language: Английский

---

Repurposing potential of FDA‐approved and investigational drugs for COVID‐19 targeting SARS‐CoV‐2 spike and main protease and validation by machine learning algorithm

Chemical Biology & Drug Design, Journal Year: 2020, Volume and Issue: 97(4), P. 836 - 853

Published: Dec. 8, 2020

Abstract The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA‐approved and investigational) against SARS‐CoV‐2 target proteins that facilitates viral entry replication into host body. To evaluate molecular affinities between associated such as spike protein (S) main protease (M pro ), a interaction simulation was performed by docking software (MVD) subsequently applicability score calculated machine learning algorithm. Furthermore, STITCH algorithm used predict pharmacology network involving multiple pathways active candidate(s). Pharmacophore features drug(s) molecule also determined structure–activity relationship (SAR). analysis showed cordycepin has strong binding with S (−180) M (−205) which were relatively highest among other used. Interestingly, compounds low IC 50 high energy. revealed scores (0.42–0.47) cordycepin. It is worth mentioning depicted involvement in different bacterial diseases including tuberculosis, hepatitis B, influenza A, myocarditis, herpes simplex infection. embedded pharmacophore suggested SAR. Cordycepin's anti‐SARS‐CoV‐2 activity indicated 65% (E‐gene) 42% (N‐gene) inhibition after 48h treatment. Since, both preclinical clinical evidences on activity, addition findings further validate suggest COVID‐19.

Language: Английский

---

Tobacco and Nervous System Development and Function—New Findings 2015–2020

Brain Sciences, Journal Year: 2021, Volume and Issue: 11(6), P. 797 - 797

Published: June 16, 2021

Tobacco is a one of the most common addictive stimulants used by people around world. The smoke generated during tobacco combustion toxic mixture more than 5000 chemicals which over 30 are known human carcinogens. While its negative effects on body well understood, it remains serious public health problem. One multiple smoking tobacco's effect nervous system-its development and function. This review aims to summarize progress made in research system both perinatal period adults animals humans 2015-2020. 1245 results that corresponded keywords "tobacco, cigarette, system, brain, morphology, function" were reviewed, 200 abstracts considered significant. Most those articles broadened knowledge about system. has significant impact structures, neurotransmission cognitive functions, promotes neurodegenerative diseases, insomnia cerebrovascular diseases. only exception protective dopaminergic Parkinson's disease. In conclusion, recent years much effort been devoted describing, revealing uncovering new aspects detrimental life. nicotine contained affects multidimensional way, including broadly understood neurological health.

Language: Английский

---

Acetylcholinesterase and human cancers

Advances in cancer research, Journal Year: 2021, Volume and Issue: unknown, P. 1 - 66

Published: Jan. 1, 2021

Language: Английский

---