NLRP3 inflammasome in neuroinflammation and central nervous system diseases

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Neuroinflammation plays an important role in the pathogenesis of various central nervous system (CNS) diseases. The NLRP3 inflammasome is intracellular multiprotein complex composed innate immune receptor NLRP3, adaptor protein ASC, and protease caspase-1. activation can induce pyroptosis release proinflammatory cytokines IL-1β IL-18, thus playing a inflammatory responses. Recent studies have revealed that activated brain to neuroinflammation, leading further neuronal damage functional impairment, contributes pathological process neurological diseases, such as multiple sclerosis, Parkinson’s disease, Alzheimer’s stroke. In this review, we summarize neuroinflammation course CNS diseases discuss potential approaches target for treatment

Language: Английский

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Target inhibition of NAT10-mediated ac4C modification prevents seizure behavior in mice

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110415 - 110415

Published: March 1, 2025

Language: Английский

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Caspase-1 inhibitor CZL80 protects against acute seizures via amplifying the inhibitory neural transmission

Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105809 - 105809

Published: July 22, 2024

Language: Английский

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Research progress on pathogenesis and treatment of febrile seizures

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123360 - 123360

Published: Dec. 1, 2024

Language: Английский

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