American Journal of Hematology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Abstract
PIEZO1
encodes
a
mechanoreceptor,
cation
channel
activated
by
mechanical
stimuli.
Gain‐of‐function
(GoF)
variants
in
cause
dehydrated
hereditary
stomatocytosis
(DHS),
or
xerocytosis,
pleiotropic
syndrome
characterized
anemia
and
iron
overload.
DHS
patients
develop
hepatic
overload
independent
of
the
degree
transfusion
regimen.
PIEZO1‐GoF
suppress
hepcidin
expression
both
cellular
model
constitutive/macrophage‐specific
Piezo1‐GoF
mice
model.
Therefore,
regulate
crosstalk
between
hepatocytes
(HCs)
macrophages
with
still
unknown
mechanism.
Transcriptomic
proteomics
analysis
human
Hep3B
cells
engineered
for
PIEZO1‐R2456H
variant
(PIEZO1‐KI)
revealed
alterations
actin
cytoskeleton
regulation,
MAPK
cascade,
RAS
signaling.
These
changes
mainly
occur
through
novel
key
regulator,
RRAS,
whose
protein
mRNA
levels
are
regulated
activation
inhibition.
This
regulation
was
further
confirmed
C57BL/6
mouse
primary
HCs
treated
Yoda‐1
and/or
GsMTx‐4.
Indeed,
PIEZO1‐KI
exhibited
hyper‐activated
RAS‐GTPase
activity
that
is
rescued
inhibition,
restoring
gene
HAMP
.
A
negative
correlation
signaling
inhibiting
MEK1‐2
activity.
Conversely,
requires
downregulation
confirming
feedback
RAS‐MAPK
BMP/SMADs
pathways
regulation.
We
demonstrated
influence
organization
activating
system.
Understanding
role
regulating
metabolism
could
pave
way
new
therapeutic
strategies
other
conditions
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Abstract
Pelvic
organ
prolapse
(POP)
is
a
common
and
distressing
condition
affecting
women,
particularly
those
with
history
of
vaginal
delivery.
The
impact
extracellular
vesicles
derived
from
adipose‐derived
mesenchymal
stem
cells
(ADSC‐EVs)
on
pelvic
floor
tissue
injury
remains
unclear.
Due
to
their
short
half‐life
rapid
clearance
in
vivo,
ADSC‐EVs
lose
efficacy
quickly.
To
address
this,
an
injectable
tetra‐PEG
hydrogel
encapsulate
(PEG@EVs)
developed.
formed
by
tetra‐PEG‐NH
2
tetra‐PEG‐NHS
through
ammonolysis
reaction,
leading
the
formation
amide
bonds
within
seconds.
Vaginal
wall
POP
patients
shows
disruption
matrix,
lipid
peroxidation,
inflammation.
In
vitro,
significantly
reduce
H₂O₂‐induced
oxidative
stress,
oxidation,
apoptosis,
while
enhancing
expression
Nrf2
its
downstream
targets—CAT,
NQO1,
HO‐1,
SOD2.
also
upregulate
GPX4
SLC7A11,
reducing
mitochondrial
damage
mitigating
ferroptosis.
inhibitor
ML385
reverses
these
protective
effects.
rat
model
childbirth
injury,
PEG@EVs
treatment
promotes
nuclear
translocation,
induces
M1‐to‐M2
macrophage
conversion,
reduces
inflammation,
stimulates
collagen
deposition,
thereby
accelerating
repair.
findings
this
study
may
serve
as
foundation
for
early
targeted
intervention
POP,
representing
promising
therapeutic
approach.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Degenerative
bone
and
joint
diseases
(DBJDs),
characterized
by
osteoporosis,
osteoarthritis,
chronic
inflammation
of
surrounding
soft
tissues,
are
systemic
conditions
primarily
affecting
the
skeletal
system.
Ferroptosis,
a
programmed
cell
death
pathway
distinct
from
apoptosis,
autophagy,
necroptosis.
Accumulating
evidence
suggests
that
ferroptosis
is
intricately
linked
to
pathogenesis
DBJDs,
targeting
its
regulation
could
be
beneficial
in
managing
these
conditions.
Natural
products,
known
for
their
anti-inflammatory
antioxidant
properties,
have
shown
unique
advantages
preventing
potentially
through
modulating
ferroptosis.
This
article
provides
an
overview
latest
research
on
ferroptosis,
with
focus
role
DBJDs
therapeutic
potential
natural
products
this
pathway,
offering
novel
insights
prevention
treatment
DBJDs.
