Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117496 - 117496
Published: April 1, 2025
Language: Английский
Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 16, 2025
Abstract Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, sustainability. This comprehensive review explores the synthesis, characterization, applications phytonanoparticles tissue engineering. The green synthesis approach, utilizing plant extracts reducing stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis. We examine mechanisms by which phytonanoparticles, particularly those derived from gold, silver, zinc oxide, influence key molecular pathways osteogenesis, including RUNX2 Osterix signaling. discusses advanced strategies phyto-nanoparticle design, such surface functionalization stimuli-responsive release mechanisms, enhance their efficacy applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, mineralization are critically analyzed, along emerging clinical data. Despite results, scalability, standardization, regulatory approval challenges persist. also addresses economic environmental implications production. Looking ahead, we identify research directions, developing personalized therapies, combination approaches stem cells or gene delivery, long-term safety assessments. By harnessing power plant-derived nanomaterials, represent an innovative approach to addressing complex regeneration, potential spanning dental, orthopedic, maxillofacial surgery. Graphical abstract
Language: Английский
Citations
1
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113716 - 113716
Published: Feb. 1, 2025
Language: Английский
Citations
1
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)
Published: March 4, 2025
Language: Английский
Citations
1
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
The oxidative stress microenvironment and mitochondrial dysfunction in chondrocytes are key mechanisms the development of osteoarthritis (OA). Metformin (Met) has demonstrated multiple effects on mitochondria is regarded as a potential therapeutic agent for OA. low blood flow characteristics joint cavity make targeted local delivery metformin crucial its clinical application. In this study, tannic acid (TA), with natural antioxidant anti-inflammatory properties, was used to prepare self-assemble Met-loaded TA nanoparticles (NPs). NPs exhibit excellent reactive oxygen scavenging capability, stability various media, an acid-responsive release Met. Vitro experiments showed that possess biocompatibility, effectively protecting chondrocyte viability OA's pathological environment preventing senescence phenotype. addition, promoted expression elements chondrocytes, restored membrane potential, enhanced mitocytosis improve quality. vivo further confirmed intra-articular injection rats post-traumatic OA improves cartilage matrix degradation, osteophyte formation, subchondral bone sclerosis over 8 weeks. Tissue staining protective mitochondria. Importantly, both vitro revealed provided superior cellular protection compared or Met alone. Overall, study demonstrates against degeneration, advantages easy preparation, high efficiency, biosafety.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 7, 2025
Tumors, as a disease that seriously threatens human health, have always been major challenge in the field of medicine. Currently, main methods tumor treatment include surgery, radiotherapy, chemotherapy, etc., but these traditional often certain limitations. In addition, recurrence and metastasis are also difficult problems faced clinical treatment. this context, importance metal-based nanomaterials therapy is increasingly highlighted. Metal-based possess unique physical, chemical, biological properties, providing new ideas for can achieve targeted tumors through various mechanisms, reducing damage to normal tissues; they serve drug carriers, improving stability bioavailability drugs; at same time, some photothermal, photodynamic, other characteristics, which be used phototherapy tumors. This review examines latest advances application within past 5 years, presents prospective insights into future applications.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 22, 2025
Abstract The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within joint cavity. This study introduces a co‐delivery system of integrating nanoenzymes gene therapeutics sequentially modified with guanidinium‐based polymers membranes to achieve synergistic therapeutic effects. is named MACP siTNF‐α nanoparticles (NPs). are designed for targeted delivery inflamed site, where they preferentially internalized by M1‐type macrophages efficiently evade lysosomal degradation. Subsequently, operates via self‐sustaining positive feedback drug release mechanism. biomimetic nanoplatform reduces reactive oxygen species (ROS) levels prevents glutathione (GSH) depletion. GSH degrades small interfering RNA (siRNA) expose Prussian blue (PB) nanoenzymes, which effectively scavenge ROS restore levels. loop significantly enhances silencing capability scavenging efficiency system. In summary, NPs can reverse ecological niche soils through dual mechanism inhibiting expression tumor necrosis factor‐alpha (TNF‐α) upstream pathway response, eliminating ROS, thus realizing efficient treatment RA.
Language: Английский
Citations
0
Silicon, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Nanoparticles (NPs) have been extensively researched for targeted diagnostic imaging and drug delivery, yet their clinical translation remains limited, with only a few achieving Food Drug Administration approval. This limited success is primarily due to challenges in precise organ- or tissue-specific targeting, which arise from off-target tissue accumulation suboptimal clearance profiles. Herein we examine the critical role of physicochemical properties, including size, surface charge, shape, elasticity, hardness, density, governing biodistribution, targetability, NPs. We highlight recent advancements engineering NPs showcasing both significant progress remaining field nanomedicine. Additionally, discuss emerging tools technologies that are being developed address these challenges. Based on insights materials science, biomedical engineering, computational biology, research, propose key design considerations next-generation nanomedicines enhanced organ selectivity.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101782 - 101782
Published: April 1, 2025
Language: Английский
Citations
0
Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117496 - 117496
Published: April 1, 2025
Language: Английский
Citations
0