Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside DOI Creative Commons
Yifan Ding, Fan Li, Yunyun Wang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 313 - 313

Published: Feb. 28, 2025

Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression IDD driven by excessive oxidative stress, inflammation, apoptosis, fibrosis, which disrupt the balance between anabolic catabolic processes, extracellular matrix (ECM) degradation IDD. Current treatment options, such as conservative therapy surgical intervention, are limited in halting disease often exacerbate adjacent discs. This review highlights challenges treating IDD, particularly due drug delivery efficiency intervertebral (IVD). It explores potential nanobiomedicine various nanomaterial-based systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, nanomaterial-composite hydrogels. These advanced systems can enhance targeted delivery, improve local concentration, sustain retention within IVD, offering promising therapeutic strategies address also examines effects these nanomaterials on focusing their impact metabolism, stem cell migration differentiation, aiming provide innovative for regeneration.

Language: Английский

Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside DOI Creative Commons
Yifan Ding, Fan Li, Yunyun Wang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 313 - 313

Published: Feb. 28, 2025

Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression IDD driven by excessive oxidative stress, inflammation, apoptosis, fibrosis, which disrupt the balance between anabolic catabolic processes, extracellular matrix (ECM) degradation IDD. Current treatment options, such as conservative therapy surgical intervention, are limited in halting disease often exacerbate adjacent discs. This review highlights challenges treating IDD, particularly due drug delivery efficiency intervertebral (IVD). It explores potential nanobiomedicine various nanomaterial-based systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, nanomaterial-composite hydrogels. These advanced systems can enhance targeted delivery, improve local concentration, sustain retention within IVD, offering promising therapeutic strategies address also examines effects these nanomaterials on focusing their impact metabolism, stem cell migration differentiation, aiming provide innovative for regeneration.

Language: Английский

Citations

0