Role of sirtuins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic potential

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143591 - 143591

Published: April 27, 2025

The high incidence and mortality rate of cardiac arrest (CA) establishes it as a critical clinical challenge in emergency medicine globally. Despite continuous advances advanced life support (ALS) technology, the prognosis for patients experiencing remains poor, with cerebral ischemia reperfusion injury (CIRI) being significant determinant adverse neurological outcomes increased mortality. Sirtuins (SIRTs) are class highly evolutionarily conserved NAD+-dependent histone deacylenzymes capable regulating expression various cytoprotective genes to play neuroprotective role CIRI. SIRTs mainly regulate levels downstream proteins such PGC 1-α, Nrf 2, NLRP 3, FoxOs, PINK 1 inhibit inflammatory response, attenuate oxidative stress, improve mitochondrial dysfunction, promote angiogenesis, apoptosis while reducing Natural active ingredients widely used protein level body because their multi-components, multi-pathway, multi-target, minimal toxic side effects. However, these naturally still face many challenges related drug targeting, pharmacokinetic properties, delivery. emergence vigorous development new delivery systems, nanoparticles, micromilk, exosomes, provide strong solving above problems. In context rapid molecular biology non-coding RNA (NcRNA), represented by miRNA LncRNA, offers great potential achieving gene-level precision medicine. multidisciplinary integration, combining biotechnology, omics technologies, artificial intelligence, material science will strongly deepening basic research expand application. This review describes major signaling pathways targeting mitigate CIRI, well current status Chinese Western medical means intervention SIRTs. Meanwhile, possible solutions application targeted drugs summarized. industrial crossover, direction future is discussed valuable reference researchers clinicians diagnosis treatment effects

Language: Английский

The advances in acetylation modification in senescence and aging-related diseases

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Aging is a process in which organisms or cells undergo decline their functions. Epigenetic modification changes have been recognized as senescence hallmark both natural aging and stimulation-induced senescence. An acetylation dynamic process, plays crucial role the through DNA stability, metabolism, signaling pathways. We summarized regulatory pathways of modifications Various cell fate-determining proteins regulate multiple cellular processes modifications. These interact coordinate with each other, forming an integrated network framework that collectively drives via systemic mechanisms. Based on these findings, we proposed "acetylation-network regulation-cellular senescence" model, to elaborate how contributes believe this insight could provide new directions intervention strategies for aging-related diseases.

Language: Английский

Ahr Deficiency Exacerbates Inflammation in Diabetic Wounds Via Impaired Mitophagy and Cgas-Sting-Nlrp3 Activation: Therapeutic Potential of Hydrogels Loaded with Ficz

Published: Jan. 1, 2025

Language: Английский