Beyond the Brain: Exploring the multi-organ axes in Parkinson’s disease pathogenesis DOI Creative Commons
Tingting Liu, Haojie Wu, Jianshe Wei

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Parkinson's Disease (PD), a complex neurodegenerative disorder, is increasingly recognized as systemic condition involving multi-organ interactions. Emerging evidence highlights roles of organ-brain axes (lung-, liver-, heart-, muscle-, bone-, and gut-brain) in PD pathogenesis. These communicate via neural, circulatory, endocrine, inflammatory pathways, collectively driving neurodegeneration. For example, lung dysfunction involves respiratory impairment signaling, while gut dysbiosis triggers α-synuclein aggregation the vagus nerve. Such cross-organ interactions underscore PD's nature, challenging traditional brain-centric models. 1. Decipher mechanisms linking peripheral organs (e.g., lung, gut) to shared pathways. 2. Explore bidirectional liver metabolism affecting neurotoxin clearance). 3. Propose therapeutic strategies targeting integrated signaling networks. Key Scientific Concepts Review. Lung-Brain Axis: Respiratory (motor impairment, inflammation) exacerbates Liver-Brain Metabolic dysregulation alters clearance; drugs levodopa) impact function. Heart-Brain Autonomic reduces cerebral blood flow; neuroendocrine changes promote pathology. 4. Muscle-Brain Neuromuscular/metabolic disruptions worsen motor symptoms. 5. Bone-Brain Bone-derived hormones (osteocalcin, OCN) inflammation influence cognition. 6. Gut-Brain Dysbiosis drives misfolding; metabolites modulate neuroinflammation. Integrated Mechanisms: Shared pathways (neuroinflammation, oxidative stress) create regulatory network, suggesting therapies crosstalk probiotics, anti-inflammatory agents).

Language: Английский

Fascial Manual Medicine: The Concept of Fascial Continuum DOI Open Access
Bruno Bordoni, Allan R Escher

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Fascial tissue ubiquitously pervades the body system, becoming target of many disciplines that use manual techniques for patient treatment. It is a much-debated topic as there currently no univocal definition among different authors. Due to non-discontinuity fascia, we can speak fascial continuum; this principle basis osteopathic perspective. This vision, which seems banal, not always applied in medicine, where, often, it conditioned by reductionist (layers) and mechanistic (compartments) approach, forgetting machine but an organism. continuity teaches treatment does only reverberate area where operator's hands rest creates series local systemic adaptations. narrative review revises concept continuum highlighting fascia system (different tissues working harmony), multi-organ (capable behaving like organ), whose macroscopic functional expression (movement) microscopic (with cellular adaptations) derives from nanoscopic coherence (electromagnetic behaviors). means acts unit, makes approach never systemic. The aim article highlight fact single biological entity (solid fluid), medicine segment, entire person.

Language: Английский

Citations

0
Beyond the Brain: Exploring the multi-organ axes in Parkinson’s disease pathogenesis DOI Creative Commons
Tingting Liu, Haojie Wu, Jianshe Wei

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Parkinson's Disease (PD), a complex neurodegenerative disorder, is increasingly recognized as systemic condition involving multi-organ interactions. Emerging evidence highlights roles of organ-brain axes (lung-, liver-, heart-, muscle-, bone-, and gut-brain) in PD pathogenesis. These communicate via neural, circulatory, endocrine, inflammatory pathways, collectively driving neurodegeneration. For example, lung dysfunction involves respiratory impairment signaling, while gut dysbiosis triggers α-synuclein aggregation the vagus nerve. Such cross-organ interactions underscore PD's nature, challenging traditional brain-centric models. 1. Decipher mechanisms linking peripheral organs (e.g., lung, gut) to shared pathways. 2. Explore bidirectional liver metabolism affecting neurotoxin clearance). 3. Propose therapeutic strategies targeting integrated signaling networks. Key Scientific Concepts Review. Lung-Brain Axis: Respiratory (motor impairment, inflammation) exacerbates Liver-Brain Metabolic dysregulation alters clearance; drugs levodopa) impact function. Heart-Brain Autonomic reduces cerebral blood flow; neuroendocrine changes promote pathology. 4. Muscle-Brain Neuromuscular/metabolic disruptions worsen motor symptoms. 5. Bone-Brain Bone-derived hormones (osteocalcin, OCN) inflammation influence cognition. 6. Gut-Brain Dysbiosis drives misfolding; metabolites modulate neuroinflammation. Integrated Mechanisms: Shared pathways (neuroinflammation, oxidative stress) create regulatory network, suggesting therapies crosstalk probiotics, anti-inflammatory agents).

Language: Английский

Citations

0