Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 12, 2021

Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates progression treatment resistance, whereas induction of acute inflammatory reactions often stimulates the maturation dendritic cells (DCs) antigen presentation, leading anti-tumor immune responses. In addition, multiple signaling pathways, such as nuclear factor kappa B (NF-kB), Janus kinase/signal transducers activators transcription (JAK-STAT), toll-like receptor (TLR) cGAS/STING, mitogen-activated protein kinase (MAPK); factors, including cytokines (e.g., interleukin (IL), interferon (IFN), necrosis (TNF)-α), chemokines C-C motif chemokine ligands (CCLs) C-X-C (CXCLs)), growth factors vascular endothelial (VEGF), transforming (TGF)-β), inflammasome; well metabolites prostaglandins, leukotrienes, thromboxane, specialized proresolving mediators (SPM), have been identified pivotal regulators initiation resolution inflammation. Nowadays, local irradiation, recombinant cytokines, neutralizing antibodies, small-molecule inhibitors, DC vaccines, oncolytic viruses, TLR agonists, SPM developed specifically modulate in cancer therapy, with some these already undergoing clinical trials. Herein, we discuss crosstalk between processes. We also highlight potential targets for harnessing cancer.

Language: Английский

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Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Journal for ImmunoTherapy of Cancer, Journal Year: 2021, Volume and Issue: 9(1), P. e001341 - e001341

Published: Jan. 1, 2021

Macrophages are the most important phagocytes in vivo. However, tumor microenvironment can affect function and polarization of macrophages form tumor-associated (TAMs). Usually, abundance TAMs tumors is closely associated with poor prognosis. Preclinical studies have identified pathways regulating infiltration during progression. Furthermore, potential therapeutic strategies targeting been studied, including inhibition macrophage recruitment to tumors, functional repolarization toward an antitumor phenotype, other that elicit macrophage-mediated extracellular phagocytosis intracellular destruction cancer cells. Therefore, increasing impact immunotherapy, new target now being discussed.

Language: Английский

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Role of lysosomes in physiological activities, diseases, and therapy

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: May 14, 2021

Abstract Long known as digestive organelles, lysosomes have now emerged multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing evidence also implicates role of lysosome-related mechanisms in pathologic process. In this review, we discuss physiological function and, more importantly, how the homeostasis is disrupted several diseases, including atherosclerosis, neurodegenerative autoimmune disorders, pancreatitis, lysosomal storage malignant tumors. atherosclerosis Gaucher disease, dysfunction changes cytokine secretion from macrophages, partially through inflammasome activation. defect autophagy facilitates accumulation toxic protein dysfunctional organelles leading to neuron death. Lysosomal has been demonstrated pathology pancreatitis. Abnormal activation or inhibition revealed disorders. tumor microenvironment, phenotypes, tumorigenesis, growth regulation, invasion, drug resistance, radiotherapy cells behaviors tumor-associated fibroblasts, dendritic cells, T are mediated by lysosomes. Based on these findings, a series therapeutic methods targeting proteins processes developed bench bedside. word, present researches corroborate be pivotal understanding tumors developing novel strategies.

Language: Английский

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Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Oct. 11, 2019

Abstract The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects host pathophysiology. Remarkable progress large-scale sequencing mass spectrometry has increased our understanding influence and/or its metabolites onset progression extraintestinal cancers efficacy cancer immunotherapy. Given plasticity microbial composition function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, probiotics, as well fecal transplantation, potentially permit development novel strategies for therapy improve clinical outcomes. Herein, we summarize latest evidence involvement immunity metabolism, effects immune response, modulate microbiome, discuss ongoing studies future areas research that deserve focused efforts.

Language: Английский

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Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 11, 2021

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC only cured by surgical resection in its early stage, but there remains relatively high possibility of recurrence. The development closely associated with the tumor microenvironment. Tumor-associated macrophages (TAMs) are one most abundant immune cell populations pancreatic stroma. TAMs inclined to M2 deviation microenvironment, which promotes and supports behaviors, including tumorigenesis, escape, metastasis, chemotherapeutic resistance. Herein, we comprehensively reviewed latest researches on origin, polarization, functions, reprogramming PDAC.

Language: Английский

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Inflammation: the incubator of the tumor microenvironment

Trends in cancer, Journal Year: 2022, Volume and Issue: 8(11), P. 901 - 914

Published: July 28, 2022

Language: Английский

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New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 23, 2021

The past decade has witnessed groundbreaking advances in the field of microbiome research. An area where immense implications have been demonstrated is tumor biology. affects initiation and progression through direct effects on cells indirectly manipulation immune system. It can also determine response to cancer therapies predict disease survival. Modulation be harnessed potentiate efficacy immunotherapies decrease their toxicity. In this review, we comprehensively dissect recent evidence regarding interaction anti-tumor machinery outline critical questions which need addressed as further explore dynamic colloquy.

Language: Английский

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Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 2, 2024

Abstract Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, mechanisms governing metastasis are not fully elucidated. Contemporary findings in domain biology have shed light on molecular aspects this intricate process. Tumor cells undergoing invasion engage with other cellular entities proteins en route their destination. Insights into these engagements enhanced our comprehension principles directing movement adaptability metastatic cells. The tumor microenvironment plays role facilitating proliferation by enabling navigate through stromal barriers. Such attributes influenced genetic epigenetic changes occurring surrounding milieu. A profound understanding process’s biological indispensable for devising efficacious therapeutic strategies. This review delves recent developments concerning metastasis-associated genes, important signaling pathways, microenvironment, metabolic processes, peripheral immunity, mechanical forces metastasis. In addition, we combine advances particular emphasis prospect developing effective interventions including most popular immunotherapies nanotechnology combat We also identified limitations current research metastasis, encompassing drug resistance, restricted animal models, inadequate biomarkers early detection methods, as well heterogeneity among others. It anticipated that comprehensive will significantly contribute advancement research.

Language: Английский

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The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 44(2), P. 539 - 567

Published: Sept. 3, 2023

Abstract Over the past decade, colorectal cancer has reported a higher incidence in younger adults and lower mortality rate. Recently, influence of intestinal flora initiation, progression, treatment been extensively studied, as well their positive therapeutic impact on inflammation microenvironment. Historically, traditional Chinese medicine (TCM) widely used via promoted cell apoptosis, inhibited metastasis, reduced drug resistance side effects. The present research is more effect either herbal or cancer. interactions between TCM are bidirectional combined impacts gut microbiota colon should not be neglected. Therefore, this review discusses role bacteria progression by inhibiting carcinogenesis, participating therapy, assisting healing. Then complex anticolon effects different kinds monomers, pairs, prescriptions embodied immune suppression, summarized separately. In addition, interaction were analyzed. This provides mechanistic reference for application clinical paves way development microbiome TCM.

Language: Английский

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Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

Oncogene, Journal Year: 2024, Volume and Issue: 43(31), P. 2389 - 2404

Published: June 18, 2024

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter macrophages, thereby reducing its transcription. This loss affected immunosuppressive activities regulatory T cells (Tregs) antitumor CD8

Language: Английский

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