Comparison of plasma mitochondrial DNA copy number in asymptomatic and symptomatic COVID-19 patients DOI Creative Commons
Shahrzad Shoraka, Seyed Reza Mohebbi, Seyed Masoud Hosseini

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 6, 2023

Introduction Since the beginning of COVID-19 pandemic, a wide clinical spectrum, from asymptomatic infection to mild or severe disease and death, have been reported in patients. Studies suggested several possible factors, which may affect outcome COVID-19. A pro-inflammatory state impaired antiviral response as major contributing factors Considering that mitochondria an important role regulating immune responses pathogens, signaling, cell it has received much attention SARS-CoV-2 infection. Recent studies demonstrated high levels cell-free mitochondrial DNA ( cf -mtDNA) are associated with increased risk intensive care unit (ICU) admission mortality. However, there few on -mtDNA infection, mainly focusing critically ill cases. In present study, we investigated copy number patients compared between symptomatic cases, assessed values. We also determined -nuclear -nDNA) transcription factor (TFAM) mRNA level studied groups. Materials methods Plasma buffy coat samples were collected 37 33 controls. Briefly, after total extraction, plasma -mtDNA, -nDNA numbers measured by absolute qPCR using standard curve method. Furthermore, RNA extraction cDNA synthesis, TFAM evaluated qPCR. Results The results showed statistically significantly higher than cases p value = 0.01). 0.00). There was no significant difference these two groups > 0.05). Also, good diagnostic potential subgroups. Conclusion is probably due its inflammation response. It can be promising candidate biomarker for diagnosis Further investigation will help understanding pathophysiology effective therapeutic strategies.

Language: Английский

Extracellular vesicles derived from mesenchymal stem cells ameliorate sulfur mustard-induced lung injury by regulating apoptosis via miR-146a-5p DOI
Zhipeng Pei,

Yunrui Sun,

Shanshan Zhang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114285 - 114285

Published: Feb. 16, 2025

Language: Английский

Citations

0
COVID‐19 and neurodegeneration: The mitochondrial connection DOI Creative Commons

Christopher Anthony Denaro,

Yara I. Haloush,

Samuel Yien Hsiao

et al.

Aging Cell, Journal Year: 2022, Volume and Issue: 21(11)

Published: Oct. 11, 2022

Abstract There is still a significant lack of knowledge regarding many aspects the etiopathology and consequences severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in humans. For example, variety molecular mechanisms mediating this infection, long‐term disease remain poorly understood. It first seemed like SARS‐CoV‐2 primarily caused serious syndrome. However, over last years, an increasing number studies also pointed towards damaging effects has on central nervous system (CNS). In fact, evidence suggests possible disruption blood–brain barrier deleterious CNS, especially patients who already suffer from other pathologies, such as neurodegenerative disorders. The behind these CNS could involve dysregulation mitochondrial physiology, well‐known early marker neurodegeneration hallmark aging. Moreover, mitochondria are involved activation inflammatory response, which been broadly described COVID‐19. Here, we critically review current bibliography presence symptoms COVID‐19 patients, with special emphasis

Language: Английский

Citations

17
SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin DOI
Qi Xiang, Jie Wu, Yuzheng Zhou

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127659 - 127659

Published: Feb. 21, 2024

Language: Английский

Citations

3
A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation DOI Creative Commons

Leyi Cheng,

Yajuan Rui, Yanpu Wang

et al.

Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 31(1)

Published: July 13, 2024

Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role. Notably, highly pathogenic coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV exhibit greater array non-structural compared to low-pathogenic strains, facilitating their ability induce via multiple pathways. Moreover, these are adept at dampening host immune responses, thereby bolstering replication persistence. This review delves into intricate interplay between apoptosis, systematically elucidating molecular mechanisms underpinning induction by proteins. Furthermore, it explores potential therapeutic avenues stemming from inhibition antiviral agents utilization apoptosis-inducing modalities. These insights not only shed light on pathogenesis but also offer novel perspectives cancer therapy.

Language: Английский

Citations

3
Comparison of plasma mitochondrial DNA copy number in asymptomatic and symptomatic COVID-19 patients DOI Creative Commons
Shahrzad Shoraka, Seyed Reza Mohebbi, Seyed Masoud Hosseini

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 6, 2023

Introduction Since the beginning of COVID-19 pandemic, a wide clinical spectrum, from asymptomatic infection to mild or severe disease and death, have been reported in patients. Studies suggested several possible factors, which may affect outcome COVID-19. A pro-inflammatory state impaired antiviral response as major contributing factors Considering that mitochondria an important role regulating immune responses pathogens, signaling, cell it has received much attention SARS-CoV-2 infection. Recent studies demonstrated high levels cell-free mitochondrial DNA ( cf -mtDNA) are associated with increased risk intensive care unit (ICU) admission mortality. However, there few on -mtDNA infection, mainly focusing critically ill cases. In present study, we investigated copy number patients compared between symptomatic cases, assessed values. We also determined -nuclear -nDNA) transcription factor (TFAM) mRNA level studied groups. Materials methods Plasma buffy coat samples were collected 37 33 controls. Briefly, after total extraction, plasma -mtDNA, -nDNA numbers measured by absolute qPCR using standard curve method. Furthermore, RNA extraction cDNA synthesis, TFAM evaluated qPCR. Results The results showed statistically significantly higher than cases p value = 0.01). 0.00). There was no significant difference these two groups > 0.05). Also, good diagnostic potential subgroups. Conclusion is probably due its inflammation response. It can be promising candidate biomarker for diagnosis Further investigation will help understanding pathophysiology effective therapeutic strategies.

Language: Английский

Citations

8