Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology DOI Creative Commons

S.-H.I. Ou,

Xiaoya Nie,

Xiangyu Qiu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Language: Английский

Recent progress in ferroptosis: inducers and inhibitors DOI Creative Commons

Yunxi Du,

Zhong Guo

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: Dec. 29, 2022

Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities pursuit to reveal the mechanism key targets because closely related pathophysiological processes many diseases. Recent studies have shown some targets, such as glutathione peroxidase 4 (GPX4) System Xc-, several inducers inhibitors been developed regulate these targets. With emergence on made developments. The selection use are very important for work. This paper briefly introduces regulatory metabolic pathway, lists categorizes commonly used recently inhibitors, discusses their medical application. ends with potential future direction ferroptosis.

Language: Английский

Citations

181
CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis DOI Creative Commons
Yang Jiang, Junshuang Zhao, Rongqing Li

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: Oct. 20, 2022

Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles ferroptosis via several mechanisms, including regulating iron metabolism, glutathione lipid peroxidation mitochondrial-related proteins, there many circRNAs need be found, they may become new molecular treatment target GBM.The expression levels circLRFN5, PRRX2 GCH1 were detected by qPCR, western blotting, immunohistochemistry. Lentiviral-based infections used overexpress or knockdown these molecules glioma stem cells (GSCs). The biological functions on GSCs MTS (3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium), 5-ethynyl-20-deoxyuridine (EdU) incorporation assay, transwell, neurosphere formation assays, Extreme Limiting Dilution Analysis (ELDA) xenograft experiments. content was BODIPY 581/591 C11 (GSH) assay malondialdehyde (MDA) assay. mechanisms among studied RNA immunoprecipitation pull-down ubiquitination dual-luciferase reporter chromatin assay.We circRNA circLRFN5 downregulated GBM associated with patients' poor prognosis. CircLRFN5 overexpression inhibits viabilities, proliferation, neurospheres formation, stemness tumorigenesis inducing ferroptosis. Mechanistically, binds protein promotes its degradation ubiquitin-mediated proteasomal pathway. can transcriptionally upregulate GSCs, which suppressor generating antioxidant tetrahydrobiopterin (BH4).Our study as tumor-suppressive identified role GBM. potential biomarker for therapies ferroptosis-dependent therapy

Language: Английский

Citations

90
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases DOI Creative Commons
Yumin Wang, Jing Hu, Shuang Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 10, 2023

Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt

Language: Английский

Citations

77
Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging DOI Creative Commons
Min Jun Ko, Sunhong Min, Hyunsik Hong

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

Citations

53
Biological functions and clinical significance of tRNA-derived small fragment (tsRNA) in tumors: Current state and future perspectives DOI Creative Commons
Qun Chen,

Danrui Li,

Luyang Jiang

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216701 - 216701

Published: Feb. 16, 2024

A new class of noncoding RNAs, tsRNAs are not only abundant in humans but also have high tissue specificity. Recently, an increasing number studies explored the correlations between and tumors, showing that can affect biological behaviors tumor cells, such as proliferation, apoptosis metastasis, by modulating protein translation, RNA transcription or posttranscriptional regulation. In addition, widely distributed stably expressed, which endows them with broad application prospects diagnosing predicting prognosis they expected to become biomarkers. However, notably, current research on still faces problems need be solved. this review, we describe characteristics well their unique features functions tumors. Moreover, discuss potential opportunities challenges clinical applications tsRNAs.

Language: Английский

Citations

22
Osteomyelitis and non-coding RNAS: A new dimension in disease understanding DOI
Md Sadique Hussain, Nusrat K. Shaikh, Mohit Agrawal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155186 - 155186

Published: Feb. 2, 2024

Language: Английский

Citations

18
The crosstalk between exosomal miRNA and ferroptosis: A narrative review DOI
Zahra Nashtahosseini, Masoumeh Nejatollahi, Ahmad Fazilat

et al.

Biology of the Cell, Journal Year: 2025, Volume and Issue: 117(1)

Published: Jan. 1, 2025

Ferroptosis is a type of cell death that multiple mechanisms and pathways contribute to the positive negative regulation it. For example, increased levels reactive oxygen species (ROS) induce ferroptosis. ferroptosis unlike apoptosis, it not dependent on caspases, but iron. Exosomes are membrane-bound vesicles with size about 30 150 nm, contain various cellular components, including DNA, RNA, microRNAs (miRNAs), lipids, proteins, which genetically similar their cells origin. found in all bodily fluids, blood, saliva, urine. Cells often release exosomes after fusion membrane. They play an important role immune cell-cell communication. miRNAs, noncoding RNAs length 18 24 nucleotides, involved regulating gene expression transcription. Emerging data suggests exosomal miRNAs implicated pathophysiological cells, metastasis, drug resistance, death. In addition, functional studies have indicated can key modulation by Therefore, this review, given importance ferroptosis, we decided elucidate relationship between diseases.

Language: Английский

Citations

3
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase DOI Creative Commons

Shanlong Zhang,

Kang Li,

Xiaoxue Dai

et al.

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 193, P. 202 - 212

Published: Oct. 10, 2022

Ferroptosis is a novel form of regulated cell death characterized by the iron-dependent accumulation lipid peroxides to lethal levels, which morphologically, biochemically, and genetically distinct from apoptosis, necroptosis, autophagy, pyroptosis. Manganese play an important role in innate immunity antitumor immunity. Many manganese-based nanomaterials induce tumor catalyzing production reactive oxygen species (ROS) within tumor. However, exact underlying mechanisms remain unclear. As research on ferroptosis advances its regulatory tumors continue be refined, more evidence has suggested that triggering cells effective strategy for treatment. In this study, we found administration MnCl2 resulted peroxidation increased levels mitochondrial ROS, consequently leading ferroptosis. Dihydroorotate dehydrogenase (DHODH)-mediated defence targetable vulnerability cancer. We show downregulated DHODH expression cells, resulting ROS addition, enhanced phosphorylation STING, TBK1, IRF3 upregulated type-I interferon (IFN), produced cGAS-STING signaling pathway. When inhibiting pathway or IFN, was restored, reversing rescuing MnCl2-induced ferroptosis.. Knockout IFNAR1 overexpression weakens effect MnCl2. Mechanistically, these results revealed treatment-activated promote releasing IFNs reduce function thereby inducing cells. This may provide new complement existing treatment regimens.

Language: Английский

Citations

59
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1 DOI Creative Commons
Jianglin Zheng, Qing Zhang,

Zhen Zhao

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: May 19, 2023

Abstract Background Ferroptosis has been linked to tumor progression and resistance antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of cells, while the function molecular mechanism lncRNA ferroptosis are yet be clarified glioma. Methods Both gain-of-function loss-of-function experiments were employed investigate effects SNAI3-AS1 on tumorigenesis susceptibility glioma vitro vivo. Bioinformatics analysis, Bisulfite sequencing PCR, pull-down, RIP, MeRIP dual-luciferase reporter assay performed explore low expression downstream Results We found that inducer erastin downregulates by increasing DNA methylation level promoter. functions as suppressor Importantly, enhances anti-tumor activity promoting both Mechanistically, competitively binds SND1 perturbs m 6 A-dependent recognition Nrf2 mRNA 3’UTR SND1, thereby reducing stability Nrf2. Rescue confirmed overexpression silence can rescue gain- ferroptotic phenotypes SNAI3-AS1, respectively. Conclusions Our findings elucidate effect detailed SNAI3-AS1/SND1/Nrf2 signalling axis ferroptosis, provide theoretical support for inducing improve treatment.

Language: Английский

Citations

33
USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization DOI Creative Commons
Jianing Tang,

Guo Long,

Xiao Liang

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(6)

Published: June 13, 2023

Abstract Hepatocellular carcinoma (HCC) is the most common type of primary hepatic carcinoma, which a growing public health problem worldwide. One main genetic alterations in HCC deregulated Wnt/β-catenin signaling, activation β-catenin associated with progression HCC. In present study, we aimed to identify novel modulators controlling ubiquitination and stability. USP8 was overexpressed tissues correlated protein level. High expression indicated poor prognosis patients. depletion significantly decreased level, target genes TOP-luciferase activity cells. Further mechanistic study revealed that USP domain interacted ARM β-catenin. stabilized via inhibiting K48-specific poly-ubiquitination process on protein. addition, inhibited proliferation, invasion stemness cells conferred ferroptosis resistance, effects could be further rescued by overexpression. inhibitor DUB-IN-3 aggressive phenotype promoted through degradation Thus, our demonstrated activated Wnt/beta-catenin signaling post-translational mechanism Targeting may serve as promising strategy for patients

Language: Английский

Citations

32