The regulatory effects and applications of TIGIT/CD155 on the tumor microenvironment in HCC DOI Creative Commons
W. Li, Yukun Li, Li Yao

et al.

View, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Hepatocellular carcinoma (HCC) is the most commonly occurring liver cancer, and poses a significant burden on individuals, society, economy, healthcare system. Despite advancements in therapeutic options such as surgical interventions targeted therapies, complex etiology clinical presentations of cancer continue to result suboptimal treatment responses. Therefore, identifying more effective methods has become priority HCC research. Targeting programmed cell death protein 1 with immune checkpoint inhibitors significantly improved outcomes; however, these drugs are still limited by their efficacy risk immune‐related adverse reactions, which can death. TIGIT, newly emerging checkpoint, provides novel focus for immunotherapy. The TIGIT/CD155 axis actively reprograms tumor microenvironment (TME), driving carcinogenesis, evasion, metastatic spread. This review systematically elucidates dynamic regulatory networks biological impacts TME, while evaluating its potential through two exploratory strategies: (i) TIGIT have augment anticancer PD‐1/PD‐L1 blockade, (ii) combination regimens integrating TIGIT‐targeted therapies antibody–drug conjugates (ADCs) or chimeric antigen receptor macrophages (CAR‐Ms) could represent viable approach overcoming limitations inherent monotherapy.

Language: Английский

SLAMF8 regulates Fc receptor-mediated phagocytosis in mouse macrophage cells through PI3K-Akt signaling DOI

Zhihao Liu,

Jing Hu,

Xingzhi Han

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: 273, P. 106990 - 106990

Published: Feb. 20, 2025

Language: Английский

Citations

0
Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma DOI Creative Commons
Xi Chen, Fei Song, Peng Xiao

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 5, 2025

Head and neck squamous cell carcinoma (HNSCC) is among the most aggressive malignancies, underscoring need for early diagnosis to improve patient outcomes. Tumor-derived exosomes, which can be non-invasively obtained reflect metabolic state of tumors in real-time, are under increasing investigation their diagnostic potential. Herein we analyzed metabolite differences serum, tissues from patients with HNSCC identify potential biomarkers clinical relevance. Non-targeted metabolomics based on liquid chromatography-mass spectrometry was employed quantify metabolites exosome, tissue samples 11 six without cancer. The profiles were through univariate multivariate statistical methods, differential analysis, pathway enrichment analysis. We identified three 45 33 tissues. Notably, exhibited significant disruptions protein amino acid metabolism. Spermine exclusively detected exosomes HNSCC. hypothesize that spermine extracellularly secreted by malignant cells via subsequently enters bloodstream. Moreover, synthase highly expressed Knocking down markedly impaired proliferation migration. This study provides a preliminarily characterization profile highlights its synthetic pathways as therapeutic targets. Future studies warranted elucidate mechanism action explore utility development.

Language: Английский

Citations

0
Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases DOI
Jing Lü, Minghao Yin, Yixuan Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

Citations

0
Ubiquitination in hepatocellular carcinoma immunity DOI Creative Commons
Jianan Zhao, Yuxuan Li, Jie Zhu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 23, 2025

Language: Английский

Citations

0
Gut microbiota derived L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages DOI
Yuanyuan Li, Yuqing Liu, Juanjuan Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Abstract Gut microbiota can affect the occurrence and development of obesity. But exact mechanism(s) by which obesity is prevented still not fully understood. In this study, we found that L-ornithine (L-orn) from gut lactobacillus helps mice to resist high-fat diet (HFD) mediated through its metabolite spermine (SPM) spermindine (SPD) in macrophages. SPM reduced inflammatory cytokines macrophages inhibiting NF-κB AKT (protein kinase B) signal pathways, while SPD activated Src induced indoleamine 2, 3-dioxygenase 1 (IDO-1) promote immunosuppressive IDO-1 Notably, L-orn was inversely associated with body mass index (BMI) obese patients. Sc-RNA sequencing data also showed pathways were significantly up-regulated signaling pathway down-regulated adipose tissues. Thus, our results suggest derived control metabolites anti-inflammatory

Language: Английский

Citations

0
TGFβ-activated Asporin interacts with STMN1 to promote prostate cancer docetaxel chemoresistance and metastasis by upregulating the Wnt/β-catenin signaling pathway DOI
Shengdong Ge,

Jinpeng Cen,

Xiaofeng Liu

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101227 - 101227

Published: March 8, 2025

Language: Английский

Citations

0
The regulatory effects and applications of TIGIT/CD155 on the tumor microenvironment in HCC DOI Creative Commons
W. Li, Yukun Li, Li Yao

et al.

View, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Hepatocellular carcinoma (HCC) is the most commonly occurring liver cancer, and poses a significant burden on individuals, society, economy, healthcare system. Despite advancements in therapeutic options such as surgical interventions targeted therapies, complex etiology clinical presentations of cancer continue to result suboptimal treatment responses. Therefore, identifying more effective methods has become priority HCC research. Targeting programmed cell death protein 1 with immune checkpoint inhibitors significantly improved outcomes; however, these drugs are still limited by their efficacy risk immune‐related adverse reactions, which can death. TIGIT, newly emerging checkpoint, provides novel focus for immunotherapy. The TIGIT/CD155 axis actively reprograms tumor microenvironment (TME), driving carcinogenesis, evasion, metastatic spread. This review systematically elucidates dynamic regulatory networks biological impacts TME, while evaluating its potential through two exploratory strategies: (i) TIGIT have augment anticancer PD‐1/PD‐L1 blockade, (ii) combination regimens integrating TIGIT‐targeted therapies antibody–drug conjugates (ADCs) or chimeric antigen receptor macrophages (CAR‐Ms) could represent viable approach overcoming limitations inherent monotherapy.

Language: Английский

Citations

0