Targeting apoptosis in cancer therapy

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(7), P. 395 - 417

Published: March 23, 2020

Language: Английский

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Cancer stem cell (CSC) resistance drivers

Life Sciences, Journal Year: 2019, Volume and Issue: 234, P. 116781 - 116781

Published: Aug. 17, 2019

Language: Английский

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Immunogenic Cell Death Induction by Ionizing Radiation

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 20, 2021

Immunogenic cell death (ICD) is a form of regulated (RCD) induced by various stresses and produces antitumor immunity via damage-associated molecular patterns (DAMPs) release or exposure, mainly including high mobility group box 1 (HMGB1), calreticulin (CRT), adenosine triphosphate (ATP), heat shock proteins (HSPs). Emerging evidence has suggested that ionizing radiation (IR) can induce ICD, the dose, type, fractionation irradiation influence induction ICD. At present, IR-induced ICD verified in vitro mice there few clinical about it. To boost IR, some strategies have shown synergy with IR to enhance immune response, such as hyperthermia, nanoparticles, chemotherapy. In this review, we focus on mechanisms ICD-promoting factors associated irradiation, immunogenic forms death. Finally, summarize methods improving IR.

Language: Английский

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Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance

Frontiers in Oncology, Journal Year: 2019, Volume and Issue: 9

Published: July 10, 2019

Cancer treatment with either standard chemotherapy or targeted agents often results in the emergence of drug-refractory cell populations, ultimately leading to therapy failure. The biological features drug resistant cells are largely overlapping those cancer stem and include heterogeneity, plasticity, self-renewal ability tumor-initiating capacity. Moreover, resistance is usually characterized by a suppression proliferation that can manifest as quiescence, dormancy, senescence proliferative slowdown. Alterations key cellular pathways such autophagy, unfolded protein response redox signaling, well metabolic adaptations also contribute establishment resistance, thus representing attractive therapeutic targets. complex interplay micro/macroenvironment immune system plays role dictating maintaining phenotype. Recent studies have challenged traditional views providing innovative perspectives, establishing new connections between their environment indicating unexpected strategies. In this review we discuss recent advancements understanding mechanisms underlying report novel targeting able overcome status, particular focus on strategies directed against dormant cells. Research will take us one step forward towards development approaches improvement relapse-free survival solid hematological patients.

Language: Английский

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Endoplasmic reticulum stress—a key guardian in cancer

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 30, 2024

Abstract Endoplasmic reticulum stress (ERS) is a cellular response characterized by excessive contraction of the endoplasmic (ER). It pathological hallmark many diseases, such as diabetes, obesity, and neurodegenerative diseases. In unique growth characteristic varied microenvironment cancer, high levels are necessary to maintain rapid proliferation metastasis tumor cells. This process closely related ERS, which enhances ability cells adapt unfavorable environments promotes malignant progression cancer. this paper, we review roles mechanisms ERS in cell proliferation, apoptosis, metastasis, angiogenesis, drug resistance, metabolism, immune response. We found that can modulate via unfolded protein (UPR) signaling IRE1, PERK, ATF6. Targeting may be new strategy attenuate protective effects on manuscript explores potential ERS-targeted therapies, detailing through influences cancer highlighting experimental clinical evidence supporting these strategies. Through review, aim deepen our understanding role ER development provide insights for therapy.

Language: Английский

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GRP78 as a potential therapeutic target in cancer treatment: an updated review of its role in chemoradiotherapy resistance of cancer cells

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(2)

Published: Jan. 18, 2025

Language: Английский

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Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(18), P. 4354 - 4354

Published: Sept. 5, 2019

Cancer constitutes a grave problem nowadays in view of the fact that it has become one main causes death worldwide. Poor clinical prognosis is presumably due to cancer cells metabolism as tumor microenvironment affected by oxidative stress. This event triggers adequate cellular response and thereby creates appropriate conditions for further progression. Endoplasmic reticulum (ER) stress occurs when balance between an ability ER fold transfer proteins degradation misfolded ones distorted. Since organelle relatively sensitive damage, aforementioned swiftly cause activation unfolded protein (UPR) signaling pathway. The output UPR, depending on numerous factors, may vary switch pro-survival pro-apoptotic branch, hence displays opposing effects deciding fate cell. role UPR-related tumorigenesis, such binding immunoglobulin (BiP) inositol-requiring enzyme-1α (IRE1α), activating transcription factor 6 (ATF6) or kinase R (PKR)-like endoplasmic (PERK), already been specifically described so far. Nevertheless, paradoxical outcomes UPR well gaps current knowledge, still needs be investigated. Herein we would like elicit actual link neoplastic diseases pathway, considering its major branches discussing potential use development novel, anti-cancer, targeted therapy.

Language: Английский

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Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy

Cells, Journal Year: 2020, Volume and Issue: 9(4), P. 892 - 892

Published: April 6, 2020

Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these self-renewing tumorigenic cell fractions thought to be responsible for metastasis dissemination and cases of tumor recurrence. In comparison with non-stem cells, CSCs known more resistant chemotherapy, radiotherapy, immunotherapy. Elucidation mechanisms factors that promote emergence existence their high resistance cytotoxic treatments would help develop effective CSC-targeting therapeutics. The present review is dedicated implication molecular chaperones (protein regulators polypeptide chain folding) both formation/maintenance CSC phenotype cytoprotective machinery allowing survive after drug or radiation exposure evade immune attack. major cellular chaperones, namely heat shock proteins (HSP90, HSP70, HSP40, HSP27), glucose-regulated (GRP94, GRP78, GRP75), necrosis factor receptor-associated protein 1 (TRAP1), peptidyl-prolyl isomerases, disulfide calreticulin, also transcription (HSF1) initiating HSP gene expression here considered as determinants stemness potential targets therapeutic attack on CSCs. Various approaches agents discussed may used inhibiting chaperone-dependent development/manifestations stemness.

Language: Английский

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GRP78 in lung cancer

Journal of Translational Medicine, Journal Year: 2021, Volume and Issue: 19(1)

Published: March 21, 2021

Abstract Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls quality regulates ER stress signaling through Ca 2+ binding to ER. In tumors, GRP78 often upregulated, acting as central sensor senses adapts changes tumor microenvironment, mediating cancer cells under various stimulations microenvironment trigger response. Increasing evidence has shown closely associated with progression poor prognosis lung cancer, plays an important role treatment cancer. Herein, we reviewed for first time functions mechanisms pathological processes including tumorigenesis, apoptosis, autophagy, progression, drug resistance, giving comprehensive understanding function addition, also discussed potential prognostic biomarker therapeutic target which conducive improving assessment development new interventions.

Language: Английский

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HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 21, 2022

HSP70 and HSP90 are two powerful chaperone machineries involved in survival proliferation of tumor cells. Residing various cellular compartments, perform specific functions. Concurrently, homologs may also translocate from their primary site under stress conditions. Herein, we address the current literature on role networks cancer. The goal is to provide a comprehensive review functions cytosolic, mitochondrial endoplasmic reticulum Given that high expression enhances development associates with aggressiveness, further understanding clues for discoveries novel anti-cancer therapies.

Language: Английский

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