Neutrophils extracellular traps and ferroptosis in diabetic wounds DOI Creative Commons
Yumeng Huang, Youjun Ding,

Beizhi Wang

et al.

International Wound Journal, Journal Year: 2023, Volume and Issue: 20(9), P. 3840 - 3854

Published: May 17, 2023

Abstract Wound healing is an extremely complex process involving multiple levels of cells and tissues. It mainly completed through four stages: haemostasis, inflammation, proliferation, remodelling. When any one these stages impaired, it may lead to delayed or even transformation into chronic refractory wounds. Diabetes a kind common metabolic disease that affects approximately 500 million people worldwide, 25% whom develop skin ulcers break down repeatedly are difficult heal, making growing public health problem. Neutrophils extracellular traps ferroptosis new types programmed cell death identified in recent years have been found interact with diabetic In this paper, the normal wound interfering factors were outlined. The mechanism two kinds was also described, interaction between different wounds discussed.

Language: Английский

Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level DOI Creative Commons

Danfeng Zhang,

Yadan Li, Chunyan Du

et al.

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 12, 2022

Approximately 8-9% of the world's population is affected by autoimmune diseases, and yet mechanism autoimmunity trigger largely understudied. Two unique cell death modalities, ferroptosis pyroptosis, provide a new perspective on mechanisms leading to development treatment strategies.Using scRNA-seq datasets, aberrant trend pyroptosis-related genes were analyzed in several representative diseases (psoriasis, atopic dermatitis, vitiligo, multiple sclerosis, systemic sclerosis-associated interstitial lung disease, Crohn's experimental orchitis). Cell line models also assessed using bulk RNA-seq qPCR.A substantial difference was observed between normal disease samples involving pyroptosis. In present study, pyroptosis showed an imbalance different keratinocyte lineages psoriatic skinin addition pyroptosis-sensitive subset dermatitis (AD) skin. The results revealed that are involved epidermal melanocyte destruction vitiligo. Aberrant has been detected orchitis. adopted study identified pro-inflammatory factors can drive changes pyroptosis.These involvement pathological process at level. IFN-γ critical inducer sensitivity, two models.

Language: Английский

Citations

87
The involvement of TH17 cells in the pathogenesis of IBD DOI

Ping Jiang,

Chang Zheng, Ying Xiang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2022, Volume and Issue: 69, P. 28 - 42

Published: July 18, 2022

Language: Английский

Citations

86
Ferroptosis in health and disease DOI Creative Commons
Carsten Berndt, Hamed Alborzinia,

Vera Skafar Amen

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211

Published: May 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Language: Английский

Citations

75
Triggers for the onset and recurrence of psoriasis: a review and update DOI Creative Commons
Suwen Liu, M. L. He,

Jian Jiang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 12, 2024

Abstract Psoriasis is an immune-mediated inflammatory skin disease, involving a complex interplay between genetic and environmental factors. Previous studies have demonstrated that factors play major role in the pathogenesis of psoriasis. However, non-genetic are also necessary to trigger onset recurrence psoriasis genetically predisposed individuals, which include infections, microbiota dysbiosis gut, dysregulated lipid metabolism, sex hormones, mental illness. can be induced by other triggers, such as trauma, unhealthy lifestyles, medications. Understanding how these triggers provides insights into pathogenesis, well better clinical administration. In this review, we summarize for update current evidence on underlying mechanism elicit disease.

Language: Английский

Citations

35
Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding DOI Creative Commons
Meiting Shi,

Lu Sun,

Jiachun Wei

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 20, 2025

Language: Английский

Citations

2
Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells DOI
Huihui Hong,

Xiqin Lin,

Yu‐Dong Xu

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 849, P. 157819 - 157819

Published: Aug. 2, 2022

Language: Английский

Citations

47
Ferroptosis: Mechanism and connections with cutaneous diseases DOI Creative Commons
Lihao Liu, Ni Lian, Liqing Shi

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 4, 2023

Ferroptosis is a recognized novel form of programmed cell death pathway, featuring abnormalities in iron metabolism, SystemXc − /glutathione axis, and lipid peroxidation regulation. A variety ferroptosis inducers can influence glutathione peroxidase directly or indirectly via diverse pathways, leading to decreased antioxidant capacity, accumulated cellular peroxides, finally inducing ferroptosis. To date, mounting studies confirm the association with various cutaneous diseases, including skin homeostasis, neoplastic infectious genetic disease, inflammatory autoimmune diseases. There are shared characteristics regarding diseases terms pathophysiological mechanisms, such as oxidative stress associated metabolism disorder peroxides. Therefore, we summarize current knowledge mechanisms involved regulation for further discussion its role pathogenesis prognosis Gaining insight into underlying dermatological disorders could illuminate treatments different

Language: Английский

Citations

28
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis DOI
Akihito Yokote,

Noriyuki Imazu,

Junji Umeno

et al.

Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 58(9), P. 868 - 882

Published: July 6, 2023

Language: Английский

Citations

26
Saikosaponin A alleviates Staphylococcus aureus‐induced mastitis in mice by inhibiting ferroptosis via SIRT1/Nrf2 pathway DOI Creative Commons

Li‐Hua Zhao,

Lei Jin,

Bin Yang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(22), P. 3443 - 3450

Published: Aug. 29, 2023

Abstract Mastitis is a common and serious bacterial infection of the mammary gland. Saikosaponin A (SSA) triterpenoid saponin isolated from Bupleurum falcatum that has ability to treat various diseases. However, little known about role SSA in achieving mastitis remission. Here, we found alleviated Staphylococcus aureus ( S. )‐induced by attenuating inflammation maintaining blood‐milk barrier integrity. Furthermore, activated nuclear factor kappa B (NF‐κB) pathway upregulated p‐p65 p‐IκB. also induced ferroptosis gland mice, mainly characterized excessive iron accumulation, mitochondrial morphological changes impaired antioxidant production. ‐induced NF‐κB activation were prevented SSA. Moreover, SAA could upregulate expression SIRT1, Nrf2, HO‐1 GPX4. And inhibitory effects on reversed SIRT1 inhibitor EX‐527. In conclusion, protected through suppressing activating SIRT1/Nrf2 pathway.

Language: Английский

Citations

25
The ACSL4 Network Regulates Cell Death and Autophagy in Diseases DOI Creative Commons
Fangquan Chen, Rui Kang, Jiao Liu

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(6), P. 864 - 864

Published: June 15, 2023

Lipid metabolism, cell death, and autophagy are interconnected processes in cells. Dysregulation of lipid metabolism can lead to such as via ferroptosis apoptosis, while lipids also play a crucial role the regulation autophagosome formation. An increased autophagic response not only promotes survival but causes death depending on context, especially when selectively degrading antioxidant proteins or organelles that promote ferroptosis. ACSL4 is an enzyme catalyzes formation long-chain acyl-CoA molecules, which important intermediates biosynthesis various types lipids. found many tissues particularly abundant brain, liver, adipose tissue. linked variety diseases, including cancer, neurodegenerative disorders, cardiovascular disease, acute kidney injury, metabolic disorders (such obesity non-alcoholic fatty liver disease). In this review, we introduce structure, function, ACSL4; discuss its ferroptosis, autophagy; summarize pathological function; explore potential implications targeting treatment diseases.

Language: Английский

Citations

23