Ferroptosis is a new therapeutic target for spinal cord injury DOI Creative Commons

Xinyue Bai,

Xiaolong Liu,

Zhi-Zhong Deng

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 14, 2023

Spinal cord injury is a serious traumatic disease. As Ferroptosis has been increasingly studied in recent years, it found to be closely related the pathophysiological processes of spinal injury. Iron overload, reactive oxygen species accumulation, lipid peroxidation and glutamate accumulation associated with are all present injury, thus thought involved pathological secondary This article highlights relationship between lists substances that improve by inhibiting Ferroptosis, concludes discussion problems may encountered clinical translation inhibitors as means enabling their faster use treatment.

Language: Английский

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases DOI Creative Commons
Yumin Wang, Jing Hu, Shuang Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 10, 2023

Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt

Language: Английский

Citations

84
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis DOI Creative Commons
Jong Woo Kim, Ji-Yoon Lee,

Mihee Oh

et al.

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(8), P. 1620 - 1631

Published: Aug. 23, 2023

Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular neurodegeneration, liver disease, cancer. Although polyunsaturated fatty acids (PUFAs) membrane phospholipids are preferentially oxidized, saturated/monounsaturated (SFAs/MUFAs) also influence peroxidation ferroptosis. In this review, we first explain how cells differentially synthesize SFA/MUFAs PUFAs they control acid pools via uptake β-oxidation, impacting Furthermore, discuss stored different lipids, diacyl or ether with head groups; triglycerides; cholesterols. Moreover, these released from molecules. summary, provide an integrated view the diverse dynamic metabolic processes context ferroptosis revisiting lipidomic studies. Thus, review development therapeutic strategies for ferroptosis-related diseases.

Language: Английский

Citations

59
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury DOI Creative Commons

Lini Jin,

Binfeng Yu,

Hongju Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 208, P. 348 - 360

Published: Aug. 26, 2023

Ferroptosis in tubules has been implicated the pathogenesis of acute kidney injury (AKI), whereas regulatory mechanism remains unclear. The stimulator interferon genes (STING) is previously recognized as a critical mediator innate immunity via DNA-sensing pathway and increasingly linked to lipid peroxidation, hallmark ferroptosis. Herein we investigated role underlying STING AKI models established by ischemia/reperfusion (IR) C57BL mice. expression level was predominantly increased after IR treatment. Besides, deficiency markedly alleviated IR-induced tissue damage renal dysfunction. Consistently, vitro experiments demonstrated that increase ferroptotic cell death, ROS production decrease GSH peroxidase 4 (GPX4) tubular cells subjected ferroptosis agonist or hypoxia/reoxygenation intervention were all mitigated genetic pharmacological inhibition STING, while exacerbated overexpression. Further, these detrimental effects overexpression relied on induction ferritinophagy, i.e. autophagic degradation ferritin, leading iron overload. Mechanistically, mediated initiation ferritinophagy through interacting with nuclear receptor coactivator (NCOA4), fundamental for transfer ferritin into lysosome. Collectively, contributes during ischemic facilitating NCOA4-mediated shows potential promising therapeutic choice AKI.

Language: Английский

Citations

49
The emerging role of regulated cell death in ischemia and reperfusion-induced acute kidney injury: current evidence and future perspectives DOI Creative Commons

Chenning Li,

Ying Yu, Shuainan Zhu

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 4, 2024

Abstract Renal ischemia‒reperfusion injury (IRI) is one of the main causes acute kidney (AKI), which a potentially life-threatening condition with high mortality rate. IRI complex process involving multiple underlying mechanisms and pathways cell dysfunction. Additionally, various types death have been linked to IRI, including necroptosis, apoptosis, pyroptosis, ferroptosis. These processes operate differently varying degrees in different patients, but each plays role pathological conditions AKI. Advances understanding pathophysiology will lead development new therapeutic approaches that hold promise for improving outcomes patients This review provides an overview recent research on molecular IRI-AKI, focus regulated (RCD) forms such as Overall, targeting RCD shows potential approach treating IRI-AKI.

Language: Английский

Citations

19
Amino acid metabolism disorder and oxidative stress took part in EGCG alleviating Mn-caused ferroptosis via miR-9-5p/got1 axis DOI
Qin Zhou,

Zhiyu Hao,

Ming-Yue Qiu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137656 - 137656

Published: Feb. 21, 2025

Language: Английский

Citations

6
Cinnamaldehyde mitigates acute myocardial infarction by regulating ferroptosis through the PI3K-AKT signaling pathway DOI
Ming Yang, Dongming Lin,

Liming He

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114262 - 114262

Published: Feb. 11, 2025

Language: Английский

Citations

3
Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy DOI
Kexuan Liu, Lei Huang,

Shuangyan Qi

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(12)

Published: Jan. 19, 2023

Ferroptosis is a non-apoptotic programmed cell death caused by the accumulation of lipid peroxide. System Xc-/glutathione peroxidase 4 (GPX4) axis and iron are two main pathways regulating ferroptosis. Simultaneously, multiple also involved in ferroptosis regulation. an intense area current study. With improvement regulatory mechanisms that underlie ferroptosis, variety drugs associated with have been discovered developed for cancer therapy. Among them, traditional were initially. Small molecule compounds regulate signaling pathway complexes promote Fenton reaction become important inducing In recent years, emerging development nanotechnology has promoted research nanodrugs. Iron-based nanomaterials extensively tested as ferroptosis-inducing agents. Furthermore, nanoscale drug delivery systems offer suitable scaffold therapies. Traditional nanodrugs complementary, each their own strengths limitations. This review describes latest studies on regulation tumor cells focuses entanglement between To conclude, challenges perspectives this field put forward.

Language: Английский

Citations

42
Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases DOI Creative Commons
Qi Feng, Yang Yang, Kaidi Ren

et al.

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(12), P. 3726 - 3743

Published: Jan. 1, 2023

Ferroptosis is an iron-dependent programmed cell death pattern that characterized by iron overload, reactive oxygen species (ROS) accumulation and lipid peroxidation. Growing viewpoints support the imbalance of homeostasis disturbance metabolism contribute to tissue or organ injury in various kidney diseases triggering ferroptosis. At present, key regulators complicated network mechanisms associated with ferroptosis have been deeply studied; however, its role initiation progression has not fully revealed. Herein, we aim discuss features, ferroptosis, explore emerging roles organelles gather pharmacological progress, systematically summarize most recent discoveries about crosstalk between diseases, including renal carcinoma (RCC), acute (AKI), diabetic disease (DKD), autosomal dominant polycystic (ADPKD), fibrosis, lupus nephritis (LN) IgA nephropathy. We further conclude potential therapeutic strategies targeting for prevention treatment hope this work will provide insight study pathogenesis kidney-related diseases.

Language: Английский

Citations

37
Acute kidney injury and distant organ dysfunction–network system analysis DOI Creative Commons
Ryo Matsuura, Kent Doi, Hamid Rabb

et al.

Kidney International, Journal Year: 2023, Volume and Issue: 103(6), P. 1041 - 1055

Published: April 7, 2023

Language: Английский

Citations

35
Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway DOI Creative Commons
Yiwei Du, Xiao‐Kang Li, Tingting Wang

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: April 3, 2023

Abstract Background Ferroptosis, which is characterized by lipid peroxidation and iron accumulation, closely associated with the pathogenesis of acute renal injury (AKI). Cyanidin-3-glucoside (C3G), a typical flavonoid that has anti-inflammatory antioxidant effects on ischemia‒reperfusion (I/R) injury, can induce AMP-activated protein kinase (AMPK) activation. This study aimed to show C3G exerts nephroprotective against I/R-AKI related ferroptosis regulating AMPK pathway. Methods Hypoxia/reoxygenation (H/R)-induced HK-2 cells mice were treated or without inhibiting AMPK. The level intracellular free iron, expression ferroptosis-related proteins acyl-CoA synthetase long chain family member 4 (ACSL4) glutathione peroxidase (GPX4), levels markers 4-hydroxynonenal (4-HNE), reactive oxygen species (ROS) malondialdehyde (MDA) examined. Results We observed inhibitory effect in vitro vivo, was reversion excessive decrease 4-HNE, ROS, MDA ACSL4 expression, an increase GPX4 (GSH) levels. Notably, inhibition CC significantly abrogated models vivo vitro. Conclusion Our results provide new insight into activating

Language: Английский

Citations

29