World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(8), P. 3410 - 3427
Published: Aug. 7, 2024
Pyroptosis
is
a
type
of
programmed
cell
death
mediated
by
gasdermines
(GSDMs).
The
N-terminal
domain
GSDMs
forms
pores
in
the
plasma
membrane,
causing
membrane
rupture
and
release
contents,
leading
to
an
inflammatory
response
mediating
pyrodeath.
plays
important
role
diseases
malignant
tumors.
With
further
study
pyroptosis,
increasing
number
studies
have
shown
that
pyroptosis
pathway
can
regulate
tumor
microenvironment
antitumor
immunity
colorectal
cancer
closely
related
occurrence,
development,
treatment
prognosis
cancer.
This
review
aimed
explore
molecular
mechanism
(CRC)
provide
ideas
for
clinical
diagnosis
CRC.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(9)
Published: Sept. 1, 2024
Abstract
Cell
death
regulation
is
essential
for
tissue
homeostasis
and
its
dysregulation
often
underlies
cancer
development.
Understanding
the
different
pathways
of
cell
can
provide
novel
therapeutic
strategies
battling
cancer.
This
review
explores
several
key
mechanisms
apoptosis,
necroptosis,
autophagic
death,
ferroptosis,
pyroptosis.
The
research
gap
addressed
involves
a
thorough
analysis
how
these
be
precisely
targeted
therapy,
considering
tumor
heterogeneity
adaptation.
It
delves
into
genetic
epigenetic
factors
signaling
cascades
like
phosphatidylinositol
3‐kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR)
mitogen‐activated
protein
kinase/extracellular
signal‐regulated
(MAPK/ERK)
pathways,
which
are
critical
death.
Additionally,
interaction
microenvironment
with
cells,
particularly
influence
hypoxia,
nutrient
deprivation,
immune
cellular
interactions,
explored.
Emphasizing
strategies,
this
highlights
emerging
modulators
inducers
such
as
B
lymphoma
2
(BCL2)
homology
domain
3
(BH3)
mimetics,
tumour
necrosis
factor‐related
apoptosis‐inducing
ligand
(TRAIL),
chloroquine,
innovative
approaches
to
induce
ferroptosis
provides
insights
therapy's
future
direction,
focusing
on
multifaceted
circumvent
drug
resistance.
examination
evolving
underlines
considerable
clinical
potential
continuous
necessity
in‐depth
exploration
within
scientific
domain.
Nature,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
For
decades,
antigen
presentation
on
major
histocompatibility
complex
class
I
for
T
cell-mediated
immunity
has
been
considered
the
primary
function
of
proteasome-derived
peptides1,2.
However,
whether
products
proteasomal
degradation
play
additional
parts
in
mounting
immune
responses
remains
unknown.
Antimicrobial
peptides
serve
as
a
first
line
defence
against
invading
pathogens
before
adaptive
system
responds.
Although
protective
antimicrobial
across
numerous
tissues
is
well
established,
cellular
mechanisms
underlying
their
generation
are
not
fully
understood.
Here
we
uncover
role
proteasomes
constitutive
and
bacterial-induced
that
impede
bacterial
growth
both
vitro
vivo
by
disrupting
membranes.
In
silico
prediction
proteome-wide
cleavage
identified
hundreds
thousands
potential
with
cationic
properties
may
be
generated
en
route
to
act
defence.
Furthermore,
infection
induces
changes
proteasome
composition
function,
including
PSME3
recruitment
increased
tryptic-like
cleavage,
enhancing
activity.
Beyond
providing
mechanistic
insights
into
cell-autonomous
innate
immunity,
our
study
suggests
proteasome-cleaved
have
previously
overlooked
functions
downstream
degradation.
From
translational
standpoint,
identifying
could
provide
an
untapped
source
natural
antibiotics
biotechnological
applications
therapeutic
interventions
infectious
diseases
immunocompromised
conditions.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 21, 2024
Abstract
Chronic
inflammation
and
NLRP3
inflammasome
activation
are
among
the
determining
factors
of
breast
malignancies.
Paclitaxel
(PTX)
is
a
drug
used
in
cancer
treatment
which
sustains
prolonged
inflammation,
reducing
effectiveness
chemotherapy.
Considering
impact
inflammatory
processes
progression,
there
strong
concern
to
develop
therapeutic
strategy
targeting
for
triple-negative
(TNBC)
treatment.
Therefore,
aim
this
study
was
evaluate
potential
PTX
modulation
counterbalance
TNBC
by
inducing
programmed
cell
death
inhibiting
activity
pro-inflammatory
cytokines.
The
obtained
results
suggested
interaction
between
revealed
that
pharmacological
inhibition,
using
NLRP3-specific
inhibitor
MCC950,
genetic
silencing
specific
small
interfering
RNA,
reduced
responses
facilitated
PTX-determined
tumor
death.
Thus,
manipulation
combination
with
anti-tumor
drugs
opens
up
new
perspectives
therapy.
Frontiers in Cell Death,
Journal Year:
2025,
Volume and Issue:
3
Published: Jan. 7, 2025
Pyroptosis
is
a
form
of
proinflammatory
cell
death
characterized
by
inflammasome
activation,
pore
formation,
and
the
release
pro-inflammatory
cytokines
such
as
interleukin-1β
(IL-1β)
IL-18
upon
rupture.
Nuclear
factor-κB
(NF-κB),
prototypical
transcription
factor,
plays
critical
role
in
immune
system
regulation.
Recent
research
highlights
multifaceted
roles
NF-κB
signaling
pyroptosis.
Various
immunologically
relevant
ligands
their
receptors
can
activate
pathway
to
promote
pyroptosis,
with
Toll-like
(TLRs),
IL-1
(IL-1Rs),
TNF
(TNFRs)
being
most
prominent.
regulates
key
components
inflammasomes
involved
particularly
NLRP3
inflammasome.
studies
also
indicate
that
modulates
activation
NLRC4
AIM2
through
distinct
pathways
diverse
inflammatory
conditions,
acute
lung
injury
neuroinflammation.
Additionally,
mediates
production
cytokines,
including
IL-1β,
IL-33,
TNF-α,
which
further
regulate
This
review
examines
recent
advances
understanding
regulating
pyroptosis
during
infection
inflammation.
Investigative Ophthalmology & Visual Science,
Journal Year:
2025,
Volume and Issue:
66(1), P. 24 - 24
Published: Jan. 10, 2025
Dry
eye
disease
(DED)
is
a
common
ocular
surface
inflammatory
with
complex
pathogenesis.
Herein,
the
role
and
effect
of
gasdermin
E
(GSDME)
in
DED
pathogenesis
were
explored.
In
vitro,
flow
cytometry,
Cell
Counting
Kit-8
(CCK-8)
lactate
dehydrogenase
(LDH)
release
assays
used
to
determine
effects
hyperosmotic
stress
on
pyroptosis,
apoptosis,
cell
viability
human
corneal
epithelial
cells
(HCECs).
Quantitative
PCR
(qPCR)
Western
blot
detect
GSDME
expression
HCECs
those
transfected
si-GSDMD.
vivo,
GSDMD-knockout
(KO)
mice
study
The
qPCR,
blotting,
immunofluorescence
explore
HCEC
related
genes
proteins
GSDMD-KO
scopolamine-induced
dry
eye.
Pyroptosis
membrane
rupture
occurred,
caspase-3
protein
increased
after
treated
312
500
mOsm
sodium
chloride.
gene
levels
from
both
si-GSDMD-
mice.
Although
was
group
mice,
apoptosis
apoptosis-related
factors
PARP
not
detected.
pyroptosis-related
ASC
IL-1β
greater
than
without
involved
by
mediating
inflammation
via
pyroptosis
pathway,
inhibition
may
be
therapeutic
target
for
DED.
