The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

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Ruxolitinib enhances gastric cancer to chemotherapy by suppressing JAK/STAT3 and inducing mitochondrial dysfunction and oxidative stress

Immunopharmacology and Immunotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 26, 2025

Objective Chemoresistance in gastric cancer poses a major challenge treatment, necessitating the development of novel therapeutic strategies. This study evaluates efficacy ruxolitinib, JAK1/2 inhibitor, both sensitive and resistant cell lines.

Language: Английский

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Brusatol Inhibits the Viability of Anaplastic Thyroid Carcinoma Cells by Modulating the JAK1/STAT3 Signaling Pathway

Published: Jan. 1, 2025

Language: Английский

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Ruxolitinib as a Novel Therapeutic Agent Targeting Mitochondrial Function and Chemo-Resistance in Nasopharyngeal Carcinoma

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 753, P. 151486 - 151486

Published: Feb. 13, 2025

Language: Английский

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PINCH-1 promotes tumor growth and metastasis by enhancing DRP1-mediated mitochondrial fission in head and neck squamous cell carcinoma

Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 11, 2025

Purpose Abnormal expression of PINCH-1 has been observed in various types human cancers. However, the clinical importance and mechanism underlying its role head neck squamous cell carcinoma (HNSCC) is yet to be fully elucidated.

Language: Английский

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STAT3 Signaling Pathway in Health and Disease

MedComm, Journal Year: 2025, Volume and Issue: 6(4)

Published: March 30, 2025

ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical factor involved in multiple physiological pathological processes. While STAT3 plays an essential role homeostasis, its persistent activation has been implicated the pathogenesis various diseases, particularly cancer, bone‐related autoimmune disorders, inflammatory cardiovascular neurodegenerative conditions. The interleukin‐6/Janus kinase (JAK)/STAT3 signaling axis central to activation, influencing tumor microenvironment remodeling, angiogenesis, immune evasion, therapy resistance. Despite extensive research, precise mechanisms underlying dysregulated disease progression remain incompletely understood, no United States Food Drug Administration (USFDA)‐approved direct inhibitors currently exist. This review provides comprehensive evaluation STAT3's health disease, emphasizing involvement cancer stem cell maintenance, metastasis, inflammation, drug We systematically discuss therapeutic strategies, including JAK (tofacitinib, ruxolitinib), Src Homology 2 domain (S3I‐201, STATTIC), antisense oligonucleotides (AZD9150), nanomedicine‐based delivery systems, which enhance specificity bioavailability while reducing toxicity. By integrating molecular mechanisms, pathology, emerging interventions, this fills knowledge gap STAT3‐targeted therapy. Our insights into crosstalk, epigenetic regulation, resistance offer foundation for developing next‐generation with greater clinical efficacy translational potential.

Language: Английский

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Regulatory effect of Wnt signaling on mitochondria in cancer: from mechanism to therapy

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Cancer is one of the most significant public health challenges in new millennium, and complex mechanisms are at work to contribute its pathogenesis progression. The Wnt signaling pathways, which crucial conserved cascades involved embryological development tissue homeostasis, mitochondria, intracellular powerhouses responsible for energy production, calcium iron as well mitochondrial apoptosis eukaryotic cells, have their own regulating these pathological processes. In past decade, accumulating evidence has indicated that pathways directly regulate biogenesis function under physiological conditions. this review, we systemically summarize current understanding how particularly canonical cascade, fission, respiration, metabolism, mitochondrial-dependent cancer. addition, discuss recent advancements research anticancer agents related pharmacological targeting transduction pathway and/or function. We believe combined use pharmaceuticals mitochondria with conventional therapies, immunotherapy targeted therapy based on accurate molecular diagnosis will undoubtedly be future mainstream direction personalized cancer treatment, could benefit more patients.

Language: Английский

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Identification of Eight Histone Methylation Modification Regulators Associated With Breast Cancer Prognosis

IET Systems Biology, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 1, 2025

ABSTRACT Histone methylation is an important epigenetic modification process coordinated by histone methyltransferases, demethylases and reader proteins plays a key role in the occurrence development of cancer. This study constructed risk scoring model around regulators conducted multidimensional comprehensive analysis to reveal its potential breast cancer prognosis drug sensitivity. First, 144 (HMMRs) were subjected differential univariate Cox regression analysis, nine differentially expressed HMMRs associated with survival screened out. Next, consisting eight was using LASSO algorithm, exhibiting independent predictive values training validation cohorts. Then, immune shows that patients high‐risk group divided has weakened response. In addition, through functional genes (DEGs) between low‐risk groups, we confirmed DEGs mainly affected nucleoplasm tumour microenvironment. Finally, sensitivity demonstrated our could be useful for screening identify drugs treating BRCA patients. conclusion, these may factors

Language: Английский

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TRAF1 promotes the progression of Helicobacter pylori-associated gastric cancer through EGFR/STAT/OAS signalling

Life Sciences, Journal Year: 2025, Volume and Issue: 373, P. 123656 - 123656

Published: April 24, 2025

Language: Английский

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The Central Role of Ferroptosis-Induced Therapy Mediated by Tenacissoside H in Anaplastic Thyroid Cancer

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119908 - 119908

Published: April 1, 2025

Language: Английский

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