Targeting programmed cell death pathways in gastric cancer: a focus on pyroptosis, apoptosis, necroptosis and PANoptosis

Gene, Journal Year: 2025, Volume and Issue: 960, P. 149546 - 149546

Published: May 5, 2025

Language: Английский

---

Triphenylamine‐appended tri‐organotin complexes: Synthesis, anticancer activities, and targeted research

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(7)

Published: May 15, 2024

Mitochondria play a crucial role in mediating apoptosis and have emerged as promising therapeutic target for the treatment of cancer. Nevertheless, exploration mitochondrial mechanism anticancer activity vitro remains notably sparse. Herein, ligands 4′,4″′‐(phenylazanediyl)bis(([1,1′‐biphenyl]‐4‐carboxylic acid)) (H 2 L 1 ) 4′,4″′‐(phenylazanediyl)bis(3‐fluoro‐[1,1′‐biphenyl]‐4‐carboxylic acid) were synthesized further combined with organotin precursors auxiliary (4,4′‐bipy = 4,4′‐bipyridine, 4,4′‐bpe 4,4′‐vinylenedipyridine) to give eight complexes [(Ph 3 Sn) L] ( 1a 2a ), [(Et n 1b 2b [( ‐Bu L(4,4′‐bipy)] 1c 2c L(4,4′‐bpec)] 1d 2d ). The characterized by X‐ray single crystal diffraction, NMR H, 13 C, 119 Sn), IR, UV–Vis spectroscopy. exhibited strong against four cancer cells certain degree broad‐spectrum IC 50 ranging from 0.25 22.43 μM. Furthermore, selected representatives investigate their mechanisms. results suggested that these could mitochondria after cellular uptake, thereby inducing intracellular ROS production, leading MMP collapse activation caspase‐3, is, potentially exert effects through mitochondria‐mediated apoptotic pathway.

Language: Английский

---

Anaplastic thyroid cancer: Genetic roles, targeted therapy, and immunotherapy

Genes & Diseases, Journal Year: 2024, Volume and Issue: 12(4), P. 101403 - 101403

Published: Aug. 30, 2024

Anaplastic thyroid cancer (ATC) stands as the most formidable form of malignancy, presenting a persistent challenge in clinical management. Recent years have witnessed gradual unveiling intricate genetic underpinnings governing ATC through next-generation sequencing. The emergence this landscape has paved way for exploration targeted therapies and immunotherapies trials. Despite these strides, precise mechanisms pathogenesis identification efficacious treatments demand further investigation. Our comprehensive review stems from an extensive literature search focusing on implications, notably pivotal MAPK PI3K-AKT-mTOR signaling pathways, along with ATC. Moreover, we screen summarize advances challenges current diagnostic approaches ATC, including invasive tissue sampling represented by fine needle aspiration core biopsy, immunohistochemistry, 18F-fluorodeoxyglucose positron emission tomography/computed tomography. We also investigate enormous studies prognosis outline independent prognostic factors future assessment therapy By synthesizing literature, aim to encapsulate evolving oncology, potentially shedding light novel pathogenic avenues therapeutic exploration.

Language: Английский

---

Development and Verification of Diagnosis Model for Papillary Thyroid Cancer Based on Pyroptosis-Related Genes: A Bioinformatic and in vitro Investigation

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7761 - 7776

Published: Oct. 1, 2024

The incidence of papillary thyroid cancer (PTC) has been increasing annually; however, early diagnosis can improve patient outcomes. Pyroptosis is a programmed cell death modality that received considerable attention recently. However, no studies have reported using pyroptosis-related genes in PTC diagnosis.

Language: Английский

---

A biocompatible nanoformulation of curcumin analogue and curd exosomes targeting EphA2 signalling cascade in head and neck cancer

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 18, 2024

Language: Английский

---

The Thyroid Gland

Essentials in cytopathology series, Journal Year: 2024, Volume and Issue: unknown, P. 17 - 111

Published: Jan. 1, 2024

Language: Английский

---