Cited by Targeting Endoplasmic Reticulum Stress by Natural and Chemical Compounds Ameliorates Cisplatin-Induced Nephrotoxicity: A Review

A Review of the Therapeutic Potential of Sulfur Compounds in Allium sativum DOI

Agatha Ngukuran Jikah, Great Iruoghene Edo,

Raghda Makia

et al.

Measurement Food, Journal Year: 2024, Volume and Issue: 15, P. 100195 - 100195

Published: Aug. 28, 2024

Language: Английский

Citations

The Interplay Between Endoplasmic Reticulum Stress and Ferroptosis in Neurological Diseases DOI

Tianyu Zhai,

Bingbing Wang,

Caizhen Shi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 10, 2025

Language: Английский

Citations

Novel Insights into Neuroinflammatory Mechanisms in Traumatic Brain Injury: Focus on Pattern Recognition Receptors as Therapeutic Targets DOI

Harapriya Baral,

Ravinder K. Kaundal

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

White matter damage and degeneration in traumatic brain injury DOI

Regina C. Armstrong, Genevieve M. Sullivan, Daniel P. Perl

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(9), P. 677 - 692

Published: Aug. 10, 2024

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often leads to persistent symptoms, and the risk of poor patient outcomes increases with aging. TBI damages neurons long axons within white matter tracts are critical for communication between regions; this causes slowed information processing neuronal circuit dysfunction. This review focuses on after multifactorial processes underlie damage, potential recovery, progression degeneration. A multiscale perspective across clinical preclinical advances presented encourage interdisciplinary insights from whole-brain neuroimaging down cellular molecular responses axons, myelin, glial cells tissue.

Language: Английский

Citations

Methamphetamine and HIV-1 Tat Protein Synergistically Induce Endoplasmic Reticulum Stress to Promote TRIM13-Mediated Neuronal Autophagy DOI

Chan Wang,

Genmeng Yang,

Jian Huang

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Language: Английский

Citations

A GluN2B disease-associated variant promotes degradation of NMDA receptors via autophagy DOI

Taylor M. Benske,

Marnie P Williams,

Peipei Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory neurotransmission and their pathogenic variants can lead to proteostasis defects thus neurological diseases. However, how the network degrades is not well understood. Here, we demonstrated that R519Q GluN2B variant retained in endoplasmic reticulum (ER) fails traffic surface form functional NMDARs. Pharmacological genetic inhibition of autophagy results accumulation this variant, indicating it degraded by autophagy-lysosomal proteolysis pathway. Since has a cytosolic LIR motif, which interact with machinery, disrupting motif impairs autophagic clearance variant. Additionally, recognized ER-phagy receptors, including CCPG1 RTN3L. Our result provides molecular mechanism degradation NMDAR identifies pathway targeted therapeutic intervention disorders dysfunctional Summary NMDA Benske et al. report predispose subunits

Language: Английский

Citations

Enhanced membrane protein production in HEK293T cells via <i>ATF4</i> gene knockout: A CRISPR-Cas9 mediated approach DOI

Byung Jo Choi, Ba Reum Kim, Ho Joong Choi

et al.

Biomolecules and Biomedicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

HEK293T cells are extensively utilized for therapeutic protein production due to their human origin, which enables accurate post-translational modifications. This study aimed enhance membrane in by knocking out the ATF4 gene using CRISPR-Cas9 technology. The was edited infecting with a lentivirus carrying optimized single-guide RNA (ATF4-KO-3) and Cas9 genes. Comparative evaluations were conducted all-in-one two-vector systems. Genome sequencing productivity of ATF4-knockout (KO) compared wild-type (WT) next-generation (NGS) isolation kit, respectively. Single-cell analysis confirmed editing patterns, NGS verifying intended deletions. Membrane also assessed indirectly via flow cytometry, analyzing expressing Membrane-GFP. Compared WT cells, ATF4-KO exhibited significant increase production, 52.2 ± 19.0% improvement. Gene efficiency between two delivery systems, system demonstrating higher based on T7 endonuclease I assays. Western blot suppression increased expression proteins, including E-cadherin CD63. Quantitative PAGE revealed 77.2 30.6% purified yields, consistent observed enhancements. Flow cytometry Membrane-GFP further demonstrated 22.9 9.7% productivity. In summary, knockout significantly enhances offering potential improvements biopharmaceutical manufacturing enabling more efficient synthesis.

Language: Английский

Citations

FTO/miR-503-5p/USP10 axis regulates neuronal endoplasmic reticulum stress-mediated apoptosis in ischemic stroke DOI

Qiang Peng, Shiyao Wang,

Shi Huang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114150 - 114150

Published: Feb. 3, 2025

Language: Английский

Citations

PARP-16 regulates the PERK and IRE-1α Mediated Unfolded Protein Response in Japanese Encephalitis Virus–Infected Neural Stem/Progenitor Cells DOI

Shivangi Sharma, Anirudh Satheesan,

Atreye Majumdar

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

Hippocampal Apoptosis: Molecular Mechanisms Triggered by Toxic Cannabinoid Exposure: A Narrative Review DOI

Habibeh Mashayekhi‐Sardoo,

Mahdiyeh Hedayati-Moghadam,

Yousef Baghcheghi

et al.

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations