Expanding the knowledge of tumour necrosis factor-α-induced gasdermin E-mediated pyroptosis in psoriasis DOI
Helen Vaher

British Journal of Dermatology, Journal Year: 2024, Volume and Issue: 191(3), P. 319 - 320

Published: May 22, 2024

Journal Article Accepted manuscript Expanding the knowledge about TNF-α induced GSDME-mediated pyroptosis in psoriasis Get access Helen Vaher The LEO Foundation Skin Immunology Research Center, Department of and Microbiology, Faculty Health Medical Sciences, University Copenhagen, Denmark Email:[email protected] Search for other works by this author on: Oxford Academic Google Scholar British Dermatology, ljae223, https://doi.org/10.1093/bjd/ljae223 Published: 23 May 2024 history Received: 15 Accepted: 22

Language: Английский

Pyroptosis and its role in autoimmune skin disease DOI
Yuanjun Yao, Zehong Wang,

Junqin Li

et al.

Experimental Dermatology, Journal Year: 2024, Volume and Issue: 33(7)

Published: July 1, 2024

Autoimmune skin disease is a kind of heterogeneous with complicated pathogenesis. Many factors such as genetic, infectious, environmental and even psychological may interact together to trigger synergistic effect for the development abnormal innate adaptive immune responses. Although exact mechanisms remain unclear, recent evidence suggests that pyroptosis plays pivotal role in autoimmune disease. The feature first formation pores cellular membranes, then cell rupture release intracellular substances pro-inflammatory cytokines, interleukin-1 beta (IL-1β) IL-18. This hyperactive inflammatory programmed death damages homeostasis system advances autoimmunity. review briefly summarises molecular regulatory pyrin domain-containing protein 3 (NLRP3) inflammasome gasdermin family, well pyroptosis, highlights latest progress disease, including systemic lupus erythematosus, psoriasis, atopic dermatitis scleroderma attempts identify its potential advantages therapeutic target or prognostic biomarker these diseases.

Language: Английский

Citations

5
Caspase family in autoimmune diseases DOI

Wangzheqi Zhang,

Huang Wu,

Yan Liao

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 24(2), P. 103714 - 103714

Published: Dec. 3, 2024

Language: Английский

Citations

4
Microneedle system carrying Momordin Ic-loaded ROS-responsive hydrogel ameliorates psoriasis via targeted anti-inflammatory and reactive oxygen species (ROS)-scavenging mechanisms DOI
Chang Wang, Li Zhou, Zhiyue Han

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125530 - 125530

Published: April 1, 2025

Language: Английский

Citations

0
Gasdermins in pyroptosis, inflammation, and cancer DOI
Rui Min, Yang Bai,

N. Wang

et al.

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Inhibition of CTSC contributes to psoriasis inflammation and keratinocyte hyperproliferation by NF-κB signaling pathway DOI
Yue He,

Maoxin Huang,

Yu Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114808 - 114808

Published: May 7, 2025

Language: Английский

Citations

0
TOP2A Promotes Proliferation, Migration, and Inflammatory Response in M5-Treated Keratinocytes by Binding CTBP1 to Activate Wnt/β-Catenin Signaling DOI

Yuanwen Yang,

Shumei Liu,

Xia Xiao

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

Citations

1
Enhanced T-cell activation and chemokine-associated function in CD14-positive cells from venous sinus blood in sub-acute cerebral venous sinus thrombosis DOI Creative Commons
Yuzhou Chang,

Yu-Qi Song,

Haoyu Zhu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 13, 2024

Background Patients with sub-acute cerebral venous sinus thrombosis experience (SA.CVST) severe symptoms compared to two other sinus-related diseases, including chronic (C.CVST) and idiopathic intracranial hypertension (IIH). Objective This study aimed determine whether the different immune reactions in sinuses are related. Methods Stagnant blood was extracted by passing a microcatheter CD14 -positive cells were sorted magnetic beads subjected RNA-seq sequencing. Results Compared patients IIH, 128 genes significantly down-regulated 373 up-regulated CVST samples. The functions of these mainly focused on “immune response”, “T cell activation” “plasma membrane”. Gene Set Enrichment Analysis (GSEA) showed T survival activation-related function unregulated CVST. On hand, there 366 75 In functional annotation, differently expressed enriched “extracellular region”, “chemokine-mediated signaling pathway” response”. GSEA analysis confirmed that chemokine-related all monocyte-macrophage adhesion also up-regulated. Conclusion suggested created an activated response

Language: Английский

Citations

0
Expanding the knowledge of tumour necrosis factor-α-induced gasdermin E-mediated pyroptosis in psoriasis DOI
Helen Vaher

British Journal of Dermatology, Journal Year: 2024, Volume and Issue: 191(3), P. 319 - 320

Published: May 22, 2024

Journal Article Accepted manuscript Expanding the knowledge about TNF-α induced GSDME-mediated pyroptosis in psoriasis Get access Helen Vaher The LEO Foundation Skin Immunology Research Center, Department of and Microbiology, Faculty Health Medical Sciences, University Copenhagen, Denmark Email:[email protected] Search for other works by this author on: Oxford Academic Google Scholar British Dermatology, ljae223, https://doi.org/10.1093/bjd/ljae223 Published: 23 May 2024 history Received: 15 Accepted: 22

Language: Английский

Citations

0