Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 19, 2024
To
assess
the
efficacy
and
safety
of
stem
cell
therapy
in
human
studies
for
diabetic
peripheral
neuropathy
(DPN).
A
comprehensive
literature
review
was
performed
across
multiple
databases,
including
Ovid
MEDLINE
ALL,
Embase
via
SP,
Scopus,
Web
Science
Core
Collection,
Cochrane
CENTRAL,
up
to
January
31,
2024.
Keywords
controlled
vocabularies
related
were
used.
Inclusion
criteria
encompassed
all
trials
examining
DPN,
excluding
animal
or
vitro
studies,
papers,
conference
abstracts,
editor
letters.
Data
extraction
risk
bias
assessment
independently
by
reviewers
using
standardized
tools.
Out
5431
initial
entries,
seven
included.
Stem
therapies
included
bone
marrow-derived
mononuclear
cells
umbilical
cord-derived
mesenchymal
cells,
administered
mainly
intramuscular
transplantation.
Meta-analysis
indicated
significant
improvements
motor
nerve
conduction
velocity
(weighted
mean
differences
(WMD):
2.2,
95%
CI
1.6–2.8)
sensory
(WMD:
1.9,
1.1–2.6).
Vibration
perception
threshold
Toronto
Clinical
Scoring
System
scores
decreased
significantly
−
2.9,
4.0,
1.8,
WMD:
3.6,
5.0,
respectively).
Sensitivity
analysis
subgroup
confirmed
robustness
specificity
these
findings.
The
complications
pain
swelling
at
injection
sites,
which
disappeared
a
few
days.
shows
promise
improving
clinical
outcomes
with
evident
benefits
parameters.
Further
research
is
needed
consolidate
findings
optimize
therapeutic
protocols.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 26, 2025
Erectile
dysfunction
is
a
common
and
multifactorial
condition
that
significantly
impacts
men's
quality
of
life.
Traditional
treatments,
such
as
phosphodiesterase
type
5
inhibitors
(PDE5i),
often
fail
to
provide
lasting
benefits,
particularly
in
patients
with
underlying
health
conditions.
In
recent
years,
regenerative
medicine,
stem
cell
therapies,
has
emerged
promising
alternative
for
managing
erectile
dysfunction.
This
review
explores
the
potential
mesenchymal
stromal/stem
cells
(MSCs)
their
paracrine
effects,
including
extracellular
vesicles
(EVs),
treatment
MSCs
have
shown
remarkable
promoting
tissue
repair,
reducing
inflammation,
regenerating
smooth
muscle
cells,
offering
therapeutic
benefits
models
Clinical
trials
demonstrated
positive
outcomes
improving
function
other
clinical
parameters.
highlights
promise
MSC
therapy
dysfunction,
discusses
existing
challenges,
emphasizes
need
continued
research
refine
these
therapies
improve
long-term
patient
outcomes.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3016 - 3016
Published: March 26, 2025
The
growing
prevalence
of
diabetes
highlights
the
urgent
need
to
study
diabetic
cardiovascular
complications,
specifically
cardiomyopathy,
which
is
a
diabetes-induced
myocardial
dysfunction
independent
hypertension
or
coronary
artery
disease.
This
review
examines
role
mitochondrial
in
promoting
cardiac
and
metabolic
mechanisms
such
as
hyperglycaemia-induced
oxidative
stress.
Chronic
hyperglycaemia
insulin
resistance
can
activate
harmful
pathways,
including
advanced
glycation
end-products
(AGEs),
protein
kinase
C
(PKC)
hexosamine
signalling,
uncontrolled
reactive
oxygen
species
(ROS)
production
mishandling
Ca2+
transient.
These
processes
lead
cardiomyocyte
apoptosis,
fibrosis
contractile
dysfunction.
Moreover,
endoplasmic
reticulum
(ER)
stress
dysregulated
RNA-binding
proteins
(RBPs)
extracellular
vesicles
(EVs)
contribute
tissue
damage,
drives
function
towards
heart
failure
(HF).
Advanced
patient-derived
induced
pluripotent
stem
cell
(iPSC)
organoids
(iPS-COs)
are
transformative
tools
for
modelling
cardiomyopathy
capturing
human
disease's
genetic,
epigenetic
hallmarks.
iPS-COs
may
facilitate
precise
examination
molecular
pathways
therapeutic
interventions.
Future
research
directions
encourage
integration
models
with
mechanistic
techniques
promote
novel
strategies.
International Journal of Clinical Endocrinology and Metabolism,
Journal Year:
2025,
Volume and Issue:
11(1), P. 004 - 006
Published: Jan. 1, 2025
Intrahepatocyte
triglyceride
buildup
and
concurrent
immune
system
activation,
followed
by
histological
alterations,
tissue
destruction,
clinical
manifestations,
are
signs
of
Non-alcoholic
Fatty
Liver
Disease
(NAFLD).
One
promising
method
treating
diabetes
is
cell-based
therapy.
In
regenerative
medicine,
Mesenchymal
Stem
Cells
(MSCs),
which
can
be
isolated
from
various
sources,
such
as
bone
marrow,
adipose
tissue,
umbilical
cord,
mobilized
peripheral
blood,
have
gained
increasing
significance
.
Cell
(MSC)-derived
Extracellular
Vesicles
(EVs)
(MSC-EVs)
novel
cell-free
carriers
with
minimal
immunogenicity
that
might
inhibit
harmful
responses
in
tissues
inflamed.
EVs
may
reduce
inflammation
liver
conditions.
Advancement
the
translation
necessitates
enhanced
interdisciplinary
collaboration
between
EV
researchers,
nanomedicine
specialists,
regulatory
agencies,
institutions
required.
However,
further
vitro
vivo
studies
required
for
better
understanding
cross
talk
cells
to
clarify
potency
mechanisms
action
this
potential
therapeutic
tool.
