An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Language: Английский

An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Language: Английский

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