Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis DOI Open Access
Avital Oknin-Vaisman, Deepanjan Panda, Rostislav Novak

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Abstract Aggressive and therapy-resistant cancers present a significant challenge to treatment are associated with poor patients’ survival. Identifying molecular pathways compounds that target these is critical for improving patient outcomes. RNF4, an E3-ubiquitin ligase, pivotal in oncoprotein stabilization DNA repair, enhancing cancer cell survival driving tumorigenesis. Elevated RNF4 levels prognosis patients. Here, we describe the development of R4VPs, proteolysis-targeted chimeras-like (PROTACs-like). R4VPs promote degradation reduce its stabilized oncoproteins. Notably, induce ferroptotic death selectively cells, sparing non-tumorigenic primary cells. Surprisingly, R4VPs-induced ferroptosis independent but preferentially targets tumor-driving mutations, particularly those EGFR pathway, while not affecting PI3K-transformed effectively melanoma sarcomas including patient-derived sarcoma tumor Our findings highlight potential inducers such as therapeutic strategy therapy resistance, aggressive, hard-to-treat cancers. Teaser cells non-transomed

Language: Английский

Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis DOI
Xiangyan Chen, Tianze Jiang,

Yantao Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133942 - 133942

Published: July 16, 2024

Language: Английский

Citations

3
Navigating the crossroads of cell death interplay and intersections among ferroptosis, apoptosis and autophagy DOI
Anuupama Suchiita, Neelu Gupta, Kajal Nandi

et al.

Drug Metabolism and Personalized Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract The review article, “Navigating the Crossroads of Cell Death: Interplay and Intersections Among Ferroptosis, Apoptosis, Autophagy,” delves into complex interactions between these three key cell death pathways. Understanding how ferroptosis, apoptosis, autophagy intersect is crucial for maintaining cellular homeostasis. Each pathway represents a unique mechanism death, recent research highlights their intricate interconnections mutual influences. Exploring relationships vital comprehending cells make fate decisions processes are implicated in various diseases. review’s significance lies elucidating molecular details providing insight balance survival death. interplay among has important implications developing therapeutic interventions, particularly diseases where regulation disrupted. By examining crosstalk pathways, researchers can identify new drug targets devise strategies to modulate effectively. This aims enhance our understanding biology by offering detailed perspective on dynamic interconnected nature mechanisms.

Language: Английский

Citations

0
Computational pipeline predicting cell death suppressors as targets for cancer therapy DOI Creative Commons
Yaron Vinik,

Avi Maimon,

Harsha Raj

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110859 - 110859

Published: Aug. 30, 2024

Identification of promising targets for cancer therapy is a global effort in precision medicine. Here, we describe computational pipeline integrating transcriptomic and vulnerability responses to cell-death inducing drugs, predict suppressors as candidate therapy. The prediction based on two modules; the similarity module identify genes whose targeting results similar death-inducing correlation expression correlates cells same death-inducers. combined predictors these modules were integrated into single metric. As proof-of-concept, selected ferroptosis inducers drugs triple negative breast cancer. reliably predicted suppressors, validated by methods cellular assays. described might be used repressors various pathways potential therapeutic different types.

Language: Английский

Citations

0
Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis DOI Open Access
Avital Oknin-Vaisman, Deepanjan Panda, Rostislav Novak

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Abstract Aggressive and therapy-resistant cancers present a significant challenge to treatment are associated with poor patients’ survival. Identifying molecular pathways compounds that target these is critical for improving patient outcomes. RNF4, an E3-ubiquitin ligase, pivotal in oncoprotein stabilization DNA repair, enhancing cancer cell survival driving tumorigenesis. Elevated RNF4 levels prognosis patients. Here, we describe the development of R4VPs, proteolysis-targeted chimeras-like (PROTACs-like). R4VPs promote degradation reduce its stabilized oncoproteins. Notably, induce ferroptotic death selectively cells, sparing non-tumorigenic primary cells. Surprisingly, R4VPs-induced ferroptosis independent but preferentially targets tumor-driving mutations, particularly those EGFR pathway, while not affecting PI3K-transformed effectively melanoma sarcomas including patient-derived sarcoma tumor Our findings highlight potential inducers such as therapeutic strategy therapy resistance, aggressive, hard-to-treat cancers. Teaser cells non-transomed

Language: Английский

Citations

0