Femtosecond Laser-Induced Photothermal Effects of Ultrasmall Plasmonic Gold Nanoparticles on the Viability of Human Hepatocellular Carcinoma HepG2 Cells DOI Creative Commons
Poornima Budime Santhosh, Kamelia Hristova‐Panusheva, Todor Petrov

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2139 - 2139

Published: Dec. 23, 2024

Laser-induced photothermal therapy using gold nanoparticles (AuNPs) has emerged as a promising approach to cancer therapy. However, optimizing various laser parameters is critical for enhancing the conversion efficacy of plasmonic nanomaterials. In this regard, present study investigates effects dodecanethiol-stabilized hydrophobic ultrasmall spherical AuNPs (TEM size 2.2 ± 1.1 nm), induced by 343 nm wavelength ultrafast femtosecond-pulse with low intensity (0.1 W/cm2) 5 and 10 min, on cell morphology viability human hepatocellular carcinoma (HepG2) cells treated in vitro. The optical microscopy images showed considerable alteration overall irradiated light. Infrared thermometer measurements that temperature medium exposed increased steadily from 22 °C 46 48.5 after respectively. WST-1 assay results significant reduction viability, demonstrating synergistic therapeutic effect femtosecond HepG2 cells. obtained pave way design less expensive, effective, minimally invasive treat cancers reduced side effects.

Language: Английский

The origin and evolution of necroptosis signaling pathway in metazoa DOI

Jiejie Sun,

R Chang, Linsheng Song

et al.

Developmental & Comparative Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 105339 - 105339

Published: Feb. 1, 2025

Language: Английский

Citations

0
RIPK3 in Necroptosis and Cancer DOI Open Access

Michael J. Morgan,

You‐Sun Kim

Molecules and Cells, Journal Year: 2025, Volume and Issue: unknown, P. 100199 - 100199

Published: Feb. 1, 2025

Language: Английский

Citations

0
Regulation of Different Types of Cell Death by Noncoding RNAs: Molecular Insights and Therapeutic Implications DOI
Rajni Kumari, Satarupa Banerjee

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(5), P. 1205 - 1226

Published: April 30, 2025

Noncoding RNAs (ncRNAs) are crucial regulatory molecules in various biological processes, despite not coding for proteins. ncRNAs further divided into long noncoding (lncRNAs), microRNAs (miRNAs), and circular (circRNAs) based on the size of their nucleotides. These play roles transcriptional, post-transcriptional, epigenetic regulation. The RNAs, including lncRNAs, miRNAs, circRNAs, essential modalities cellular death, such as apoptosis, ferroptosis, cuproptosis, pyroptosis, disulfidptosis, necroptosis. integral to modulating gene expression protein functionality during death mechanisms. In circRNAs influence transcription apoptotic genes. these target genes proteins involved iron homeostasis oxidative stress responses. For regulate pathways associated with accumulation copper ions, leading death. During modulate inflammatory mediators caspases, affecting proinflammatory cell pathway. necroptosis, oversee formation necrosomes, thereby influencing balance between survival Disulfidptosis is a unique type regulated caused by excessive disulfide bonds within cells, cytoskeletal collapse stress, especially under glucose-limited conditions. This investigation highlights complex mechanisms through which coordinate emphasizing therapeutic promise potential targets, particularly domain cancer treatment.

Language: Английский

Citations

0
Femtosecond Laser-Induced Photothermal Effects of Ultrasmall Plasmonic Gold Nanoparticles on the Viability of Human Hepatocellular Carcinoma HepG2 Cells DOI Creative Commons
Poornima Budime Santhosh, Kamelia Hristova‐Panusheva, Todor Petrov

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2139 - 2139

Published: Dec. 23, 2024

Laser-induced photothermal therapy using gold nanoparticles (AuNPs) has emerged as a promising approach to cancer therapy. However, optimizing various laser parameters is critical for enhancing the conversion efficacy of plasmonic nanomaterials. In this regard, present study investigates effects dodecanethiol-stabilized hydrophobic ultrasmall spherical AuNPs (TEM size 2.2 ± 1.1 nm), induced by 343 nm wavelength ultrafast femtosecond-pulse with low intensity (0.1 W/cm2) 5 and 10 min, on cell morphology viability human hepatocellular carcinoma (HepG2) cells treated in vitro. The optical microscopy images showed considerable alteration overall irradiated light. Infrared thermometer measurements that temperature medium exposed increased steadily from 22 °C 46 48.5 after respectively. WST-1 assay results significant reduction viability, demonstrating synergistic therapeutic effect femtosecond HepG2 cells. obtained pave way design less expensive, effective, minimally invasive treat cancers reduced side effects.

Language: Английский

Citations

1