Characterization of the Peroxisomal Proteome and Redox Balance in Human Prostate Cancer Cell Lines DOI Creative Commons
Mohamed A. F. Hussein, Celien Lismont, Cláudio F. Costa

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1340 - 1340

Published: Nov. 1, 2024

Prostate cancer (PCa) is associated with disruptions in cellular redox balance. Given the intricate role of peroxisomes metabolism, we conducted comprehensive proteomics analyses to compare peroxisomal and protein profiles between benign (RWPE-1) malignant (22Rv1, LNCaP, PC3) prostate cell lines. Our revealed significant enrichment "peroxisome" pathway among proteins notably upregulated androgen receptor (AR)-positive In addition, catalase (CAT) activity was consistently higher these lines compared RWPE-1, which contrasts previous studies reporting lower CAT levels increased H

Language: Английский

Characterization of the Peroxisomal Proteome and Redox Balance in Human Prostate Cancer Cell Lines DOI Creative Commons
Mohamed A. F. Hussein, Celien Lismont, Cláudio F. Costa

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1340 - 1340

Published: Nov. 1, 2024

Prostate cancer (PCa) is associated with disruptions in cellular redox balance. Given the intricate role of peroxisomes metabolism, we conducted comprehensive proteomics analyses to compare peroxisomal and protein profiles between benign (RWPE-1) malignant (22Rv1, LNCaP, PC3) prostate cell lines. Our revealed significant enrichment "peroxisome" pathway among proteins notably upregulated androgen receptor (AR)-positive In addition, catalase (CAT) activity was consistently higher these lines compared RWPE-1, which contrasts previous studies reporting lower CAT levels increased H

Language: Английский

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