Revolutionizing Bone Tumor Therapy: Biodegradable Magnesium Implant Triggers cGAS‐STING‐Dependent Synergy of Autophagic Cell Death and Alkaline Metabolic Collapse DOI
Mei Li, Tiantian Wei, Haiming Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Abstract Bone tumors are challenging to eradicate, with conventional limb‐salvage surgeries often leading high rates of recurrence, metastasis, and severe functional impairments due large bone defects. Traditional therapies struggle balance tumor elimination preservation restoration. This study presents a novel therapeutic strategy utilizing high‐purity biodegradable magnesium (Mg) implants, which induce dual‐mode death orchestrated by the cGAS‐STING pathway. Released Mg ions trigger autophagic cell through TRPM7‐mediated uptake, promoting LC3 lipidation supplying STING‐laden ERGIC membranes. Simultaneously, alkaline degradation byproducts disrupt metabolism suppressing glycolysis oxidative phosphorylation, further targeting hexokinase 2 (HK2) amplify metabolic collapse. coordinated mechanism reshapes microenvironment, M1 macrophage polarization, CD8 + T infiltration, enhanced intratumoral IFN‐γ secretion, fostering robust, sustained immune response. The efficacy biosafety implants validated in murine osteosarcoma, patient‐derived xenografts, VX2 rabbit models, demonstrating significant suppression prolonged survival without systemic toxicity. work highlights multifunctional capabilities integrating death, suppression, modulation coordination, presenting promising clinically translatable for advanced therapy.

Language: Английский

Chimeric Antigen Receptor Cell Therapy: Empowering Treatment Strategies for Solid Tumors DOI Creative Commons
Tang‐Her Jaing, Yi-Wen Hsiao, Yi-Lun Wang

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 90 - 90

Published: Jan. 31, 2025

Chimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors been significantly limited. The differences arise from a range difficulties linked to tumors, including an unfriendly tumor microenvironment, variability within and barriers CAR-T infiltration longevity at location. Research shows that reasons for decreased cells treating are not well understood, highlighting ongoing need strategies address these challenges. Current frequently incorporate combinatorial therapies designed boost functionality enhance their capacity effectively target tumors. However, remain testing phase necessitate additional validation assess potential benefits. CAR-NK (natural killer), CAR-iNKT (invariant natural killer T), CAR-M (macrophage) emerging as promising Recent studies highlight construction optimization cells, emphasizing overcome unique challenges posed by such hypoxia metabolic barriers. This review focuses on CAR

Language: Английский

Citations

1
Recent advances in the role of high-salt diet in anti- and pro-cancer progression DOI Creative Commons
Shiwei Tang, Juan Xu, Ping Wan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney cancer, and osteoporosis. However, studies have uncovered novel aspect of HSD, suggesting that may inhibit growth specific pathological conditions by modulating the activity immune cells infiltrate tumors enhancing effectiveness PD-1 immunotherapy. This review focused duel molecular mechanisms cancer development, which are based microenvironment, gut microbiota, involvement sodium transporter channels. The objective this is to explore whether could be potential future oncological therapeutic strategy under situation.

Language: Английский

Citations

0
Study on the Mechanism of Jieduquyuziyin prescription Improving the Condition of MRL/lpr Mice by Regulating T Cell Metabolic Reprogramming through the AMPK/mTOR Pathway DOI
Qingmiao Zhu, Yaxue Han, Xiaolong Li

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 345, P. 119584 - 119584

Published: March 3, 2025

Language: Английский

Citations

0
Decoding Metabolic Changes in Cancer Cells Resistant to Therapy DOI

Shehzeen Noor,

Shaukat Ali,

Muhammad Summer

et al.

Interdisciplinary cancer research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Interdisciplinary Approaches to Leverage Biomarker Discovery for Cancer Treatment DOI
Fatemeh Khatami, Nima Rezaei

Interdisciplinary cancer research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria DOI
Heng Wang, Fang Xu, Chao Wang

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic Approaches DOI Open Access

Angelo Aquino,

Ornella Franzese

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1547 - 1547

Published: May 1, 2025

Dysregulated cell movement is a hallmark of cancer progression and metastasis, the leading cause cancer-related mortality. The metastatic cascade involves tumour migration, invasion, intravasation, dissemination, colonisation distant organs. These processes are influenced by reciprocal interactions between cells microenvironment (TME), including immune cells, stromal components, extracellular matrix proteins. epithelial–mesenchymal transition (EMT) plays crucial role in providing with invasive stem-like properties, promoting dissemination resistance to apoptosis. Conversely, mesenchymal–epithelial (MET) facilitates re-initiation. Immune within TME contribute either anti-tumour response or evasion. secrete cytokines, chemokines, growth factors that shape landscape influence responses immunotherapy. Notably, checkpoint blockade (ICB) has transformed treatment, yet its efficacy often dictated composition site. Elucidating molecular cross-talk identifying predictive biomarkers for ICB response, developing strategies convert cold tumours into immune-active environments critical overcoming immunotherapy improving patient survival.

Language: Английский

Citations

0
Targeting the kynurenine pathway in gliomas: Insights into pathogenesis, therapeutic targets, and clinical advances DOI Creative Commons

Mikolaj M. Krupa,

Tomasz Pienkowski, Anna Tankiewicz‐Kwedlo

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(3), P. 189343 - 189343

Published: May 7, 2025

Language: Английский

Citations

0
Revolutionizing Bone Tumor Therapy: Biodegradable Magnesium Implant Triggers cGAS‐STING‐Dependent Synergy of Autophagic Cell Death and Alkaline Metabolic Collapse DOI
Mei Li, Tiantian Wei, Haiming Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Abstract Bone tumors are challenging to eradicate, with conventional limb‐salvage surgeries often leading high rates of recurrence, metastasis, and severe functional impairments due large bone defects. Traditional therapies struggle balance tumor elimination preservation restoration. This study presents a novel therapeutic strategy utilizing high‐purity biodegradable magnesium (Mg) implants, which induce dual‐mode death orchestrated by the cGAS‐STING pathway. Released Mg ions trigger autophagic cell through TRPM7‐mediated uptake, promoting LC3 lipidation supplying STING‐laden ERGIC membranes. Simultaneously, alkaline degradation byproducts disrupt metabolism suppressing glycolysis oxidative phosphorylation, further targeting hexokinase 2 (HK2) amplify metabolic collapse. coordinated mechanism reshapes microenvironment, M1 macrophage polarization, CD8 + T infiltration, enhanced intratumoral IFN‐γ secretion, fostering robust, sustained immune response. The efficacy biosafety implants validated in murine osteosarcoma, patient‐derived xenografts, VX2 rabbit models, demonstrating significant suppression prolonged survival without systemic toxicity. work highlights multifunctional capabilities integrating death, suppression, modulation coordination, presenting promising clinically translatable for advanced therapy.

Language: Английский

Citations

0