Cuproptosis and its potential role in musculoskeletal disease DOI Creative Commons
Zijian Xiang, Heng Mei, Honglin Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 11, 2025

Cuproptosis, a recently identified form of copper-dependent cell death, arises from intracellular copper dyshomeostasis. As an essential trace element, plays critical role in bioenergetic metabolism, redox regulation, and synaptic transmission. However, excessive exerts cytotoxic effects through multiple pathways, including increased reactive oxygen species (ROS) production, apoptotic cascade activation, necrotic membrane rupture, inflammatory responses, mitochondrial dysfunction. Distinct other death mechanisms, cuproptosis is characterized by ion binding to acetylated respiratory chain proteins, leading pathogenic protein aggregation, iron-sulfur cluster depletion, cellular collapse. Emerging evidence underscores aberrant accumulation resultant proteotoxic stress as pivotal contributors the pathogenesis musculoskeletal pathologies, osteoporosis, osteoarthritis, sarcopenia, osteosarcoma, intervertebral disc degeneration, spinal cord injury, biofilm-associated orthopedic infections. Understanding spatiotemporal regulation may provide novel opportunities for advancing diagnostic therapeutic approaches medicine. This review synthesizes current insights into molecular mechanisms cuproptosis, its diseases, potential biomarker-driven interventions.

Language: Английский

Copper in melanoma: at the crossroad of protumorigenic and anticancer roles DOI Creative Commons

Natalia Chrzan,

Mariusz L. Hartman

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103552 - 103552

Published: Feb. 15, 2025

Language: Английский

Citations

0
Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy DOI
Suman Sekhar Sahoo, Debasish Manna

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Cancer remains one of the leading causes death individuals globally. Conventional treatment techniques like chemotherapy and radiation often suffer various drawbacks toxicity drug resistance. The study cell has been predominantly focused on classical forms apoptosis, but role metal ions in governing controlled is a fascinating less explored area. Metal‐mediated process where triggers via unique mechanism. Nanomaterial‐based strategies have gained attention for their ability to deliver precise therapeutic agents while also triggering Regulated Cell Death (RCD) mechanisms cancer cells. recently discovered metal‐mediated cuproptosis ferroptosis can be used as they selectively drug‐resistant cancer. Nano material‐based delivery system targeted sites. In this review, we given some idea about mechanism (ferroptosis cuproptosis) how initiate deaths using nanomaterials treatment.

Language: Английский

Citations

0
Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies DOI Creative Commons
Zhiquan Li, Konstantinos Palikaras, Yuan Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 27, 2025

Figure 1. The Mitochondrial Path: From Mechanisms to Therapeutics. Several mitochondria-targeted approaches show promise for promoting healthy brain aging, combating neurodegeneration, and addressing reproductive aging. This research topic highlights a new form of mitochondria-associated programmed cell death called cuproptosis, the master regulator mitochondrial biogenesis PGC-1α, oxidative stress responses where FOXO transcription factors play pivotal role in homeostasis.Synaptic plasticity is fundamental preserving function. deficits, particularly those affecting organelle distribution, motility, calcium buffering capacity, have been associated with impairments synaptic transmission, potentiation, (Todorova Blokland 2017). Navakkode Kennedy highlight importance assessing cognition alongside physical fitness lifespan aging studies. Importantly, cognitive decline not an inevitable consequence but rather process shaped by genetic, environmental, lifestyle factors. Maintaining functions reserves identifying key molecular drivers resilience enhancing neuroplasticity (possibly through interventions) could provide proactive strategy function populations.In neurological health, mitochondria also death, like apoptosis, mitophagy-associated pyroptosis, necroptosis, ferroptosis, cuproptosis (Zhu, Song et al. 2024). Cuproptosis has identified as novel copper-dependent mitochondria-mediated (Tsvetkov, Coy 2022, Wang, Zhang 2022). Fan emphasize that this emerging concept adds dimension understanding age-related diseases. While copper essential enzymatic cellular homeostasis, its dysregulation can lead protein aggregation cytotoxicity, exacerbating neurodegeneration systemic In future, potential therapeutic targets mitigating pathologies, underscoring precision medicine research.Mitochondrial are largely coordinated peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), common feature many diseases (Panes, Wendt Its biosynthesis metabolic regulation maintenance neuronal integrity. Tang describe PGC-1α protective factor against neuroinflammation, stress, autophagy-related dysfunction conditions such Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis. They discuss various compounds drug-targeting strategies may ameliorate these pathologies. As our deepens, targeting offer promising avenues improving health slowing or even preventing neurodegeneration. Future studies should focus on optimizing modulation enhance effects while minimizing off-target consequences.The regulatory hub plays protecting cells from stress. excessive reactive oxygen species (ROS) generation closely linked Notably, recent study emphasizes target, OSER1, which helps withstand (Song, Li underscore critical redox balance maintaining germ fertility. Given mitochondria's energy production pathways reduce extend both men women. interplay between damage creates cycle accelerates declines Understanding mechanisms crucial developing effective therapies address infertility. intersection longevity remains compelling frontier agingrelated research.The convergence multifaceted nature need holistic approach mitigation. integrity, regulation, metal ion adaptability interconnected influence at multiple levels. By integrating insights neurology, biology, research, scientists clinicians develop more mitochondrialtargeted interventions healthspan.As we continue unravel presents delaying neurodegenerative diseases, decline, health. challenge now lies translating groundbreaking discoveries into tangible promote

Language: Английский

Citations

0
Molecular mechanisms of alcohol-associated liver disease-ferroptosis and autophagy crosstalk DOI
Yangyang Wang,

Xin Zhou,

Hui Chen

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 4, 2025

Language: Английский

Citations

0
Cuproptosis and its potential role in musculoskeletal disease DOI Creative Commons
Zijian Xiang, Heng Mei, Honglin Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 11, 2025

Cuproptosis, a recently identified form of copper-dependent cell death, arises from intracellular copper dyshomeostasis. As an essential trace element, plays critical role in bioenergetic metabolism, redox regulation, and synaptic transmission. However, excessive exerts cytotoxic effects through multiple pathways, including increased reactive oxygen species (ROS) production, apoptotic cascade activation, necrotic membrane rupture, inflammatory responses, mitochondrial dysfunction. Distinct other death mechanisms, cuproptosis is characterized by ion binding to acetylated respiratory chain proteins, leading pathogenic protein aggregation, iron-sulfur cluster depletion, cellular collapse. Emerging evidence underscores aberrant accumulation resultant proteotoxic stress as pivotal contributors the pathogenesis musculoskeletal pathologies, osteoporosis, osteoarthritis, sarcopenia, osteosarcoma, intervertebral disc degeneration, spinal cord injury, biofilm-associated orthopedic infections. Understanding spatiotemporal regulation may provide novel opportunities for advancing diagnostic therapeutic approaches medicine. This review synthesizes current insights into molecular mechanisms cuproptosis, its diseases, potential biomarker-driven interventions.

Language: Английский

Citations

0