Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment DOI Creative Commons
Yizheng Zhang,

Shiqi Yi,

Mingyuan Luan

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

Cell death mechanisms are broadly classified into accidental cell (ACD) and regulated (RCD). ACD such as necrosis, is an uncontrolled, process, while RCD tightly by specific signaling pathways molecular mechanisms. Tumor cells characterized their ability to evade sustain uncontrolled proliferation. The failure of programmed a key contributor tumor initiation, progression, resistance cancer therapies. Traditionally, research has focused primarily on apoptosis the dominant form in cancer. However, emerging evidence highlights importance other non-apoptotic forms RCD, pyroptosis, ferroptosis, necroptosis, parthanatos, tumorigenesis treatment response. These gaining attention for potential roles overcoming therapy resistance. In this review, we will discuss recent advances study malignant tumors explore therapeutic implications, offering insights new targets strategies.

Language: Английский

Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment DOI Creative Commons
Yizheng Zhang,

Shiqi Yi,

Mingyuan Luan

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

Cell death mechanisms are broadly classified into accidental cell (ACD) and regulated (RCD). ACD such as necrosis, is an uncontrolled, process, while RCD tightly by specific signaling pathways molecular mechanisms. Tumor cells characterized their ability to evade sustain uncontrolled proliferation. The failure of programmed a key contributor tumor initiation, progression, resistance cancer therapies. Traditionally, research has focused primarily on apoptosis the dominant form in cancer. However, emerging evidence highlights importance other non-apoptotic forms RCD, pyroptosis, ferroptosis, necroptosis, parthanatos, tumorigenesis treatment response. These gaining attention for potential roles overcoming therapy resistance. In this review, we will discuss recent advances study malignant tumors explore therapeutic implications, offering insights new targets strategies.

Language: Английский

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