Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Feb. 23, 2024
Language: Английский
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Aug. 25, 2023
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancies to overcome clinically due its insidious onset as well rapid progression. It urgent seek new diagnostic markers and therapeutic targets in order furthest ameliorate prognosis patients with PDAC. V-set immunoglobulin domain containing 2 (VSIG2) belongs superfamily (IgSF), which function coinhibitory molecule mediate immune evasion tumors. Nevertheless, role VSIG2 PDAC related mechanism still keep unclear. Methods Different expression tissues cells were detected by bioinformatic analysis, immunohistochemistry, real-time quantitative PCR western blotting. CCK-8, colony formation, Transwell assay, scratch experiment utilized assess proliferation, invasion migration properties cells. The relationship late endosomal/lysosomal adaptor, MAPK MTOR activator (LAMTOR2) mechanistic target rapamycin (mTOR) was identified using mass spectrometry, co-immunoprecipitation immunofluorescence. GO KEGG enrichment analysis performed for further pathway verification Additionally, subcutaneous xenograft tumor model clinical samples implemented elucidate oncogenic effect on vivo clinically. Results highly expressed Overexpression facilitated abilities cells, while VSIG2-inhibition exerted opposite effects. Mechanistically, could simultaneously bind LAMTOR2 mTOR, thereby enhancing interaction between two molecules, resulted elevated phosphorylation-modificatory activation mTOR downstream key molecules. Clinically, up-regulation positively associated advanced stage, overall survival disease-free patients. Conclusions Our study disclosed that overexpressed PDAC, promoted metastasis. Mechanically, acted a scaffold recruit simultaneously, stabilize them, thus LAMTOR2-mediated phosphorylated activation. Collectively, be exploited biomarker diagnosis monitor future, meanwhile, targeting management expected novel strategy. Video Abstract.
Language: Английский
Citations
10
Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108336 - 108336
Published: Jan. 1, 2025
Language: Английский
Citations
0
Knowledge-Based Systems, Journal Year: 2025, Volume and Issue: 310, P. 112957 - 112957
Published: Jan. 5, 2025
Language: Английский
Citations
0
American Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(1), P. 1 - 18
Published: Jan. 1, 2025
OTU Deubiquitinase 6B-Antisense Transcript 1 (OTUD6B-AS1), a novel long non-coding RNA (lncRNA), has recently emerged as critical regulator in various tumors. Current research underscores its dual functionality, acting either an oncogene or tumor suppressor depending on the context. In this work, we compile and discuss findings from range of studies investigating expression patterns OTUD6B-AS1 different cancers consequent effects behavior, both vitro vivo. We delve into mechanisms through which influences cancer initiation progression, focusing role regulating essential cellular processes such cell growth, migration, invasion, angiogenesis, ferroptosis, treatment resistance. Operating complex interactions with microRNAs (miRNAs), proteins, pivotal signaling pathways - most notably Wnt/β-catenin exhibits variable roles across types environments. Additionally, assess clinical relevance levels, evaluating potential biomarker for prognosis diagnosis, well target therapeutic intervention. By consolidating existing knowledge, work aims to highlight implications encourage further oncology, ultimately contributing advancement targeted therapies.
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1369 - 1376
Published: Jan. 1, 2025
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110389 - 110389
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 21, 2025
Normal cells begin to grow indefinitely and immortalize form tumor after an external stimulus resulting in a genetic mutation. Effective killing of is the basis various cancer therapies. Ferroptosis class cell death types dependent on iron cellular lipid peroxidation. Tumors themselves are iron-dependent, conventional radiotherapy also sensitizes ferroptosis. Increasing sensitivity ferroptosis may be potential therapeutic strategy overcome resistance mechanisms therapy. Long noncoding RNAs (LncRNAs) transcripts more than 200 nucleotides length that regulate gene expression at multiple levels involved biological processes such as differentiation, cycle arrest, maintenance stemness. Recent studies have found lncRNAs through influence or ameliorate chemotherapeutic agents. With continuous maturation nanomaterials technology, it provide new means for treatment by regulating ferroptosis-related inside tumors well increasing Fe 2+ ROS tumors. In this paper, we systematically introduce regulatory mechanism ferroptosis, role immunotherapy application combined with nanomaterials, which provides perspectives
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 1, 2025
Gastric cancer (GC) is an exceedingly aggressive disease and ranks as the third leading cause of cancer-related deaths, which poses a huge health burden globally. Chemotherapy commonly employed during middle to advanced stages cancer, although it faces frequent treatment failures attributed drug resistance. Thus, imperative for researchers identify potential targets overcoming therapeutic resistance, thereby facilitating development novel anti-cancer agents GC patients with stages. Long noncoding RNAs (lncRNAs) are diverse group transcripts limited protein-coding capacity, have been recognized functional molecules regulating progression including cell proliferation, metastasis, resistance in GC. In this review, we examine intricate molecular networks on role lncRNAs LncRNAs conferred through various mechanisms, therefore functioning promising patients. Additionally, discuss current advancements strategies targeting therapy, may pave way lncRNA-mediated precision medicine malignant disease.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 4, 2025
Long Intergenic Non-Protein Coding RNA 1123 (LINC01123), located on human chromosome 2q13, is a pivotal factor in tumorigenesis, exerting multifaceted oncogenic effects. Its expression strongly correlates with clinicopathological features, patient survival, and disease progression. In vivo vitro experiments further demonstrate that LINC01123 influences diverse cellular processes, including proliferation, apoptosis, viability, migration, invasion, stemness, tumor growth. Notably, it also regulates metabolic reprogramming, immune escape, cell resistance to treatment. regulated by multiple transcription factors participates gene regulation through protein interactions competitive endogenous (ceRNA) networks, thereby modulating cancer-promoting This work systematically elucidates its primary functions molecular mechanisms driving cancer initiation progression, suggesting might serve as novel potential driver biomarker various cancers.
Language: Английский
Citations
0
Human Cell, Journal Year: 2025, Volume and Issue: 38(3)
Published: April 9, 2025
Language: Английский
Citations
0