Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117183 - 117183
Published: July 30, 2024
Atherosclerosis,
characterized
by
the
accumulation
of
plaque
within
arterial
walls,
is
an
intricate
cardiovascular
disease
that
often
results
in
severe
health
issues.
Recent
studies
have
emphasized
importance
ferroptosis,
a
controlled
type
cell
death
dependent
on
iron,
as
critical
factor
this
state.
Ferroptosis,
distinguished
its
reliance
iron
and
lipid
hydroperoxides,
offers
unique
insight
into
pathology
atherosclerotic
lesions.
This
summary
encapsulates
current
knowledge
role
ferroptosis
plays
onset
progression
atherosclerosis.
It
explores
molecular
processes
through
which
peroxidation
metabolism
contribute
to
development
atheromatous
plaques
evaluates
possibility
utilizing
novel
treatment
approach
for
By
illuminating
relationship
between
ferroptosis-related
atherosclerosis,
review
paves
way
future
clinical
applications
personalized
medicine
approaches
aimed
at
alleviating
effects
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(24), P. 17279 - 17279
Published: Dec. 8, 2023
Ferroptosis
is
a
form
of
cell
death
that
distinguished
from
other
types
for
its
peculiar
characteristics
regulated
by
iron
accumulation,
increase
in
ROS,
and
lipid
peroxidation.
In
the
past
few
years,
experimental
evidence
has
correlated
ferroptosis
with
various
pathological
processes
including
neurodegenerative
cardiovascular
diseases.
also
involved
several
cancer
because
it
been
shown
to
induce
tumor
death.
particular,
pharmacological
induction
ferroptosis,
contributing
inhibition
proliferative
process,
provides
new
ideas
treatment
cancer.
Emerging
suggests
certain
mechanisms
Xc−
system,
GPx4,
chelators
play
key
role
regulation
can
be
used
block
progression
many
This
review
summarizes
current
knowledge
on
mechanism
latest
advances
multiple
regulatory
pathways,
underlining
ferroptosis’
involvement
Finally,
we
focused
inducers
inhibitors,
evaluating
their
impact
principal
targets
provide
perspectives
diseases
potential
development
clinical
therapies.
Current Research in Toxicology,
Journal Year:
2024,
Volume and Issue:
7, P. 100181 - 100181
Published: Jan. 1, 2024
Sickle
cell
disease
(SCD)
is
an
inherited
hemoglobin
disorder
marked
by
red
blood
sickling,
resulting
in
severe
anemia,
painful
episodes,
extensive
organ
damage,
and
shortened
life
expectancy.
In
SCD,
increased
iron
levels
can
trigger
ferroptosis,
a
specific
type
of
death
characterized
reactive
oxygen
species
(ROS)
lipid
peroxide
accumulation,
leading
to
damage
impairments.
The
intricate
interplay
between
iron,
inflammation,
oxidative
stress
SCD
underscores
the
necessity
thoroughly
understanding
these
processes
for
development
innovative
therapeutic
strategies.
This
review
highlights
importance
balancing
complex
interactions
among
various
factors
exploitation
knowledge
developing
novel
therapeutics
this
devastating
disease.
Current Drug Targets,
Journal Year:
2024,
Volume and Issue:
25(8), P. 543 - 557
Published: May 6, 2024
Ferroptosis
is
implicated
in
the
pathogenesis
of
multiple
diseases,
including
neurodegenerative
cardiovascular
kidney
pathologies,
ischemia-reperfusion
injury,
and
cancer.
The
current
review
article
highlights
involvement
ferroptosis
traumatic
brain
acute
damage,
ethanol-induced
liver
PM2.5-induced
lung
injury.
Melatonin,
a
molecule
produced
by
pineal
gland
many
other
organs,
well
known
for
its
anti-
aging,
anti-inflammatory,
anticancer
properties
used
treatment
different
diseases.
Melatonin's
ability
to
activate
anti-ferroptosis
pathways
sirtuin
(SIRT)6/p-
nuclear
factor
erythroid
2-related
2
(Nrf2),
Nrf2/
antioxidant
responsive
element
(ARE)/
heme
oxygenase
(HO-1)/SLC7A11/glutathione
peroxidase
(GPX4)/
prostaglandin-endoperoxide
synthase
(PTGS2),
extracellular
signal-regulated
kinase
(ERK)/Nrf2,
ferroportin
(FPN),
Hippo/
Yes-associated
protein
(YAP),
Phosphoinositide
3-kinase
(PI3K)/
B
(AKT)/
mammalian
target
rapamycin
(mTOR)
SIRT6/
receptor
coactivator
4
(NCOA4)/
ferritin
heavy
chain
1
(FTH1)
signaling
suggests
that
it
could
serve
as
valuable
therapeutic
agent
preventing
cell
death
associated
with
various
Further
research
needed
fully
understand
precise
mechanisms
which
melatonin
regulates
potential
target.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117183 - 117183
Published: July 30, 2024
Atherosclerosis,
characterized
by
the
accumulation
of
plaque
within
arterial
walls,
is
an
intricate
cardiovascular
disease
that
often
results
in
severe
health
issues.
Recent
studies
have
emphasized
importance
ferroptosis,
a
controlled
type
cell
death
dependent
on
iron,
as
critical
factor
this
state.
Ferroptosis,
distinguished
its
reliance
iron
and
lipid
hydroperoxides,
offers
unique
insight
into
pathology
atherosclerotic
lesions.
This
summary
encapsulates
current
knowledge
role
ferroptosis
plays
onset
progression
atherosclerosis.
It
explores
molecular
processes
through
which
peroxidation
metabolism
contribute
to
development
atheromatous
plaques
evaluates
possibility
utilizing
novel
treatment
approach
for
By
illuminating
relationship
between
ferroptosis-related
atherosclerosis,
review
paves
way
future
clinical
applications
personalized
medicine
approaches
aimed
at
alleviating
effects
