Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 25, 2023
GENERAL COMMENTARY article Front. Immunol., 25 August 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1265565
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10127 - 10127
Published: June 14, 2023
In recent years, three emerging cell deaths, ferroptosis, necroptosis and pyroptosis, have gradually attracted everyone’s attention, they also play an important role in the occurrence development of various diseases. Ferroptosis is idiographic iron-dependent form regulated death with hallmark accumulation intracellular reactive oxygen species (ROS). Necroptosis a necrotic mediated by receptor-interacting protein kinase 1(RIPK1) 3RIPK3. Pyroptosis, known as inflammatory necrosis, programmed necrosis Gasdermin D (GSDMD). It manifested continuous swelling cells until membrane ruptures, resulting release contents activation strong response. Neurological disorders remain clinical challenge patients do not respond well to conventional treatments. Nerve can aggravate neurological This article reviews specific mechanisms these types their relationship diseases evidence for diseases; understanding pathways helpful treatment
Language: Английский
Citations
30
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 10, 2024
Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to immunotherapy is suboptimal, primarily attributed low immunogenicity in certain types of malignant tumors. Immunogenic cell death (ICD) represents form regulated (RCD) capable enhancing tumor and activating tumor-specific innate adaptive responses immunocompetent hosts. Therefore, gaining deeper understanding ICD evolution crucial developing more therapeutic strategies. This review focuses exclusively on both historical recent discoveries related modes their mechanistic insights, particularly within context immunotherapy. Our findings are also highlighted, revealing mode induction facilitated by atypical interferon (IFN)-stimulated genes (ISGs), including polo-like kinase 2 ( PLK2 ), during hyperactive type I IFN signaling. The concludes discussing potential ICD, with special attention relevance preclinical settings field
Language: Английский
Citations
13
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(2), P. 621 - 642
Published: Jan. 1, 2024
Immune checkpoint inhibitors (ICIs) have generated considerable excitement as a novel class of immunotherapeutic agents due to their remarkable efficacy in treating various types cancer.However, the widespread use ICIs has brought about number safety concerns, especially development immune-related adverse events (irAEs).These serious complications could result treatment discontinuation and even life-threatening consequences, making it critical identify high-risk groups predictive markers irAEs before initiating therapy.To this end, current article examines several potential important organs affected by ICIs.While retrospective studies yielded some promising results, limitations such small sample sizes, variable patient populations, specific cancer studied make difficult generalize findings.Therefore, prospective cohort real-world investigations are needed validate different biomarkers predicting risk.Overall, identifying is crucial step towards improving enhancing management irAEs.With ongoing research efforts, hoped that more accurate reliable will be identified incorporated into clinical practice guide decisions prevent susceptible patients.
Language: Английский
Citations
7
Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)
Published: July 10, 2023
We recently read the publication by Miao et al., "A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022" [1] with great interest.This study aimed elucidate knowledge structures, development trends research hotspots cancer.Given importance these cell death modalities cancer, study's significance merits recognition [2,3].However, we have some suggestions regarding retrieval strategies employed this study.For study, search strategy is very important.The authors mentioned that original data were acquired Web Science Core Collection (WoSCC).To our knowledge, WoSCC comprises several sub-databases, including SCI-Expanded, SSCI, A&HCI, CPCI-S, CPCI-SSH, others.Previous studies experience suggest not all sub-databases are appropriate for [4].Among them, SCI-Expanded most widely used one.Therefore, author should clearly specify which database they utilized repeatability.Additionally, researchers argue Topic Search (TS) suitable analysis.TS considers a be target when terms appear "Title (TI)", "Abstract (AB)", "Author keywords (AK)", or "Keywords plus".However, plus" generated an automatic computer algorithm WoSCC, authors.Including Plus" during process may result inclusion many unrelated publications [4,5].In experience, using "TI", "AB", "AK" as qualification maybe best option.Moreover, if formula overly simplistic omits related keywords, it overlook relevant publications.For example, only "cancer" "tumor" identify cancer-related literature.We contend insufficient locating studies.Our previous work offers detailed example searching following terms: "cancer* OR anticancer* tumor* tumour* oncology neoplasm* carcinoma*
Language: Английский
Citations
15
Environmental Pollution, Journal Year: 2024, Volume and Issue: 357, P. 124407 - 124407
Published: June 20, 2024
Polychlorinated naphthalenes (PCNs) were included in the banned list of Stockholm Convention due to their potential provoke a wide range adverse effects on living organisms and environment. Many reviews have been written clarify state knowledge identify research needs this pollutant class. However, studies yet analyse scientometric complexities PCN literature. In study, we used bibliometric R vosviewer programs as tool fill gap by focusing articles indexed Web Science Scopus databases those published between 1973 2022. A total 707 within period with publication/author, author/publication, co-authors/publication ratios 0.45, 2.19, 4.86, respectively. Developed countries dominated most indices (number publications, citations, collaboration networks) survey period. Lotka's inverse square rule author productivity showed that laws do not fit An annual percentage growth rate 7.46% Kolmogorov-Smirnoff goodness-of-fit 0.88 suggests more output PCNs is likely years come. More needed from scholars developing measure supremacy developed nations effectively comply agreement.
Language: Английский
Citations
5
Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 30 - 45
Published: Nov. 7, 2023
Cancer remains a significant global health concern, necessitating the development of innovative therapeutic strategies. This research paper aims to investigate role pyroptosis induction in cancer treatment. Pyroptosis, form programmed cell death characterized by release pro-inflammatory cytokines and formation plasma membrane pores, has gained attention as potential target for therapy. The objective this study is provide comprehensive overview current understanding its discusses concept relationship with other forms death, such apoptosis necroptosis. It explores immune activation combination also reviews use natural, biological, chemical, multifunctional composite materials cells. molecular mechanisms underlying these are discussed, along their advantages challenges findings highlight novel strategy treatment insights into different involved induction.
Language: Английский
Citations
12
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 13, 2025
Ferroptosis, a novel concept of programmed cell death proposed in 2012, kidney disease, has garnered significant attention based on evidence abnormal iron deposition and lipid peroxidation damage the kidney. Our study aim to examine trends future research directions field ferroptosis so as further explore target or treatment strategy for clinical disease. A thorough survey using Web Science Core Collection, focusing literature published between 2012 2024 examining interaction disease was conducted. VOSviewer, CiteSpace, Biblioshiny were used in-depth scientometric visualized analyses. From 2024, total 2,244 articles met inclusion criteria final analysis. The number annual publications this area showed steady pattern at beginning decade. top 3 journals with highest publication output Renal Failure, Oxidative Medicine And Cellular Longevity, Biomedicine & Pharmacotherapy. China United States had publications. Central South University Guangzhou Medical most active influential institutions. Documents citation analysis suggested that Andreas Linkermann, Jolanta Malyszko, Alberto Ortiz are researchers, by Scott J. Dixon Jose Pedro Friedmann Angeli, cited article, more important drivers development field. Keywords associated glutathione, peroxidation, nitric oxide high frequency early studies. In recent years, however, there been shift towards biomarkers, inflammation necrosis, which indicate current area. global landscape from presented. Basic mechanism exploration renal fibrosis chronic may be hot spot future.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110995 - 110995
Published: Feb. 1, 2025
Language: Английский
Citations
0
Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122680 - 122680
Published: March 1, 2025
Language: Английский
Citations
0