X and Y Differences in Melanoma Survival Between the Sexes

Pigment Cell & Melanoma Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

ABSTRACT Marked differences in survival from melanoma are noted between men and women that cannot be accounted for by behavioral differences. We others have provided evidence this difference may due to increased expression of immune‐related genes the second X chromosome because failure inactivation. In present review, we examined contrary view weaker immune responses males. One reason loss Y chromosomes (LOY), particularly older The involved direct roles or noncoding RNAs regulate both sex autosomal tumor growth. Loss KDM6C KDM5D demethylases appeared common involved. factor appears activation androgen receptors (AR) on cells increase their invasiveness Induction T‐cell exhaustion AR limits against a finding. development treatments overcome effects related gene poses challenges, but several avenues signaling appear worthy further study treatment metastatic disease.

Language: Английский

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Beyond Genes: Epiregulomes as Molecular Commanders in Innate Immunity

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113149 - 113149

Published: Sept. 14, 2024

Language: Английский

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Exploring Synergistic Inhibition of Inflammatory and Antioxidant Potential: Integrated In Silico and In Vitro Analyses of Garcinia mangostana, Curcuma comosa, and Acanthus ebracteatus

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Compared with the use of a single herb alone, combinations can significantly increase their effectiveness in treating various diseases. The objective this research was to determine appropriate proportions

Language: Английский

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Escape of Kdm6a from X chromosome is detrimental to ischemic brains via IRF5 signaling

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our prior research has suggested the escapee genes Kdm6a Kdm5c are involved microglial activation after stroke aged mice. However, underlying mechanisms remain unclear. We hypothesized Kdm6a/5c demethylate H3K27Me3/H3K4Me3 microglia respectively, mediate transcription interferon regulatory factor 5 (IRF5) IRF4, leading to pro-inflammatory responses exacerbated injury. Aged (17–20 months) conditional knockout (CKO) female mice (one allele gene) were subjected a 60-min middle cerebral artery occlusion (MCAO). Gene floxed females (two alleles) males allele) included as controls. Infarct volume behavioral deficits quantified 3 days stroke. Immune including infiltration peripheral leukocytes ischemic brain assessed by flow cytometry. Epigenetic modification IRF5/4 analyzed CUT&RUN assay. demethylation H3K27Me3 kdm6a increased IRF5 transcription; meanwhile Kdm5c demethylated H3K4Me3 repress IRF5. Both Kdm6a^fl/fl Kdm5c^fl/fl had worse outcomes compared fl/y CKO showed more robust expression CD68 microglia, elevated plasma levels IL-1β or TNF-α, concluded IRF5 signaling plays critical mediating deleterious effect Kdm6a; whereas Kdm5c’s independent IRF5.

Language: Английский

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Perspectives on materials: Reality and potential of epigenetic drug nano-delivery

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157746 - 157746

Published: Nov. 1, 2024

Language: Английский

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