Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 7, 2025
Language: Английский
MedComm, Journal Year: 2025, Volume and Issue: 6(4)
Published: March 22, 2025
Abstract Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there crucial need for multifunctional materials can effectively address complex, multiphase nature of repair while being effective easily applicable various clinical settings. This review systematically analyzes latest developments materials, examining their chemical composition, structural design, therapeutic mechanisms. We comprehensively evaluate bioactive components, including natural polymers, synthetic matrices, hybrid composites, along different forms, such as hydrogels, powders, smart dressings. Special attention is given to emerging strategies material design integrate multiple functions, sustained drug delivery, infection prevention, promotion. The insights provided this illuminate path toward next‐generation highlighting opportunities more solutions significantly improve patient outcomes reduce burden.
Language: Английский
Citations
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Circulation Research, Journal Year: 2025, Volume and Issue: 136(7), P. 773 - 802
Published: March 27, 2025
Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents complex pathological process that has long challenged therapeutic intervention. High-throughput omics technologies have begun revolutionizing our understanding the molecular mechanisms driving cardiac fibrosis are providing unprecedented insights into its heterogeneity progression. This review provides comprehensive analysis how techniques—encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics—are insight fibrosis. Genomic studies identified novel genetic variants regulatory networks associated with susceptibility progression, single-cell transcriptomics unveiled distinct fibroblast subpopulations unique signatures. Epigenomic profiling revealed dynamic chromatin modifications controlling activation states, proteomic analyses biomarkers potential targets. Metabolomic uncovered important alterations in energetics substrate utilization during fibrotic remodeling. The integration these multi-omic data sets led to identification previously unrecognized pathogenic targets, including cell-type-specific interventions metabolic modulators. We discuss advances development precision medicine approaches for while highlighting current challenges future directions translating effective strategies. systems-level perspective on may inform more effective, personalized related cardiovascular diseases.
Language: Английский
Citations
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Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 28, 2025
In recent years, the respiratory system has been increasingly recognized as a key target organ in diabetes. Although observational studies have established significant clinical associations between type 2 diabetes (T2D), antidiabetic medication use, and asthma, causal relationships underlying molecular mechanisms remain unclear. This study employed bidirectional two-sample Mendelian randomization (MR) approach combined with bioinformatics analysis to explore T2D asthma subtypes complications, focus on immune-regulatory mechanisms. The MR utilized inverse-variance weighted (IVW) meta-analysis methods evaluate overall effects, sensitivity analyses confirming robustness of findings. Bioinformatics focused differential gene expression pathway enrichment identify potential networks. showed that positive effect (P < 0.05), severe autoimmune showing strong specific (eosinophilic mixed asthma) complications (e.g., acute infections pneumonia) 0.05). identified monocyte-CCL2 signaling axis mechanism linking where hyperglycemia-induced monocyte activation may promote development. These findings reveal shared inflammatory pathways deepen our understanding these two chronic diseases.
Language: Английский
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Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: April 4, 2025
Abstract The excessive accumulation of neutrophils within the epidermis is a significant hallmark cutaneous diseases; however, mechanisms governing neutrophil transepidermal migration (NTEM) remain inadequately understood. In this study, we develop trichromatic-fluorescence-labeled chimeric mice by utilizing Cx3cr1 GFP/+ Lyz2 RFP/+ as bone marrow donors and Krt14 YFP/+ recipients. This approach enables us to visualize process NTEM crosstalk between monocytes in murine model irritant contact dermatitis (ICD). Intravital imaging reveals preferential transmigration through hair follicle (HF), where dermal exhibit limited mobility interact with monocytes. Notably, 18 h following hapten exposure, continuously migrate toward HF regions form clusters 3 h. Importantly, MMP-9 identified essential for process; depletion results reduction expression skin inhibits ICD. Mechanistically, are found be crucial source cytokines TNF-α CXCL2, which promote upregulation neutrophils. Therefore, our highlight gateways monocyte-modulated provide visual insights into inflammatory disorders.
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 7, 2025
Language: Английский
Citations
0