Perm Medical Journal,
Journal Year:
2024,
Volume and Issue:
41(6), P. 56 - 67
Published: Dec. 15, 2024
Objective.
To
determine
the
risk
factors
for
recurrence
of
endometrioid
cysts
in
infertile
patients.
Materials
and
methods.
47
women
divided
into
two
distinct
groups
participated
study.
The
first
group
(n
=
39)
consisted
reproductive
age
with
infertility
associated
ovarian
cysts,
who
experienced
no
these
a
year.
Conversely,
second
8)
comprised
age,
had
within
same
timeframe.
Blood
sampling
analysis
was
performed
all
participants
before
surgery,
on
10th
day
after
operation,
6
12
months
following
surgery.
concentrations
AXIN-1
haptoglobin
were
determined
blood
plasma.
Results.
Risk
such
as
young
28.5
(27.5–31.5),
dysmenorrhea,
bilateral
lesion,
cyst
size
5
(4–6)
cm,
well
dynamics
biomarkers
revealed
A
statistically
significant
difference
level
which
reflects
presence
oxidative
stress
provoked
by
ferroptosis
beyond
them
patients
recurrent
endometriomas.
phenomenon
shown
to
contribute
fibrosis
not
only
tissues
ovary
itself,
but
also
formation
adhesions
appendages,
most
pronounced
relapse
group.
High
its
slow
decline
reflect
aggressiveness
cellular
proliferation,
bypassing
apoptosis
leading
repeated
relapse.
combination
above-mentioned
is
promising
early
detection
–
Conclusion.
clinical,
anamnestic,
intraoperative
laboratory
data
identified
recurrence:
patients`
younger
nature
lesion
Analysis
can
be
considered
criterion
an
important
aspect
planning
surgical
intervention,
since
connection
adhesive
process
revealed.
Introduction:
The
balance
of
bioelements
is
crucial
as
it
ensures
the
organism's
homeostasis
and
proper
execution
reactions
within
body,
nerve
conductivity,
correct
polarity
cell
membranes,
but
also
very
important
for
fertility.
It
known
that
disturbances
in
lead
to
reproductive
dysfunction.
In
women,
changes
composition
follicular
fluid
can
occur,
which
limited
growth
lack
oocyte
activation.
Objective:
main
objective
was
examine
whether
concentration
Na,
K,
Ca,
Mg,
Fe
influences
outcome
vitro
fertilization
process.
Methods:
study
involved
120
female
patients
undergoing
fertilization.
Follicular
obtained
after
follicle
aspiration
ovaries
used
biological
material
analysis.
values
Na
(selective
electrode
method),
K
Ca
(arenajo
Mg
(spectrophotometric
(colorimetric
method)
were
determined
using
AU
680
apparatus,
Beckman
Coulter.
Istanbul
Consensus
criteria
clinical
embryologists
assess
embryo
quality.
Statistical
analysis
performed
SPSS
20
software
package.
Results:
Analysis
samples
showed
no
correlation
between
quality
oocytes
or
Conclusion:
Based
on
our
results,
be
concluded
does
not
affect
Veterinary World,
Journal Year:
2024,
Volume and Issue:
unknown, P. 2370 - 2375
Published: Oct. 1, 2024
Background
and
Aim:
In
females
of
various
species
experimental
animals,
iron
(Fe)
status
in
follicular
fluid
(FF)
is
associated
with
local
physiological
reproductive
events
related
to
follicle
development,
steroidogenesis,
oocyte
maturation.
However,
these
mechanisms
remain
unknown.
This
study
aimed
determine
compare
the
intrafollicular
plasma
concentrations
Fe,
ferritin
(Ferr),
transferrin
(TRF)
cycling
mares.
Materials
Methods:
Sixty
ovaries
were
collected
during
breeding
season
from
30
clinically
normal
mares
raised
for
slaughterhouse
meat
production.
Blood
samples
before
slaughter.
Follicles
classified
into
three
categories
according
size:
Small
(20–30
mm;
n
=
20),
medium
(≥31–40
large
(≥41
20).
The
FF
samples,
after
collection,
immediately
taken
laboratory
processing
centrifuged,
Fe
Ferr
supernatant
determined
by
spectrophotometry.
Results:
Although
similar
plasma,
TRF
was
significantly
higher
than
systemic
circulation
(p
<
0.05).
Follicular
development
does
not
modify
mare.
Conclusion:
Based
on
this
evidence,
it
possible
that
acquisition
molecule
possibly
originated
a
de
novo
source,
whereas
their
diffusion
through
ultrafiltration
play
relevant
role.
These
results
provide
new
scientific
insights
suggesting
its
involvement
ovarian
functions
Keywords:
ferritin,
fluid,
iron,
mare,
transferrin.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(7), P. 876 - 876
Published: July 21, 2024
Ferroptosis,
an
iron-dependent
form
of
non-apoptotic
cell
death,
plays
a
pivotal
role
in
various
diseases
and
is
gaining
considerable
attention
the
realm
endometriosis.
Considering
classical
pathomechanism
theories,
we
hypothesized
that
ferroptosis,
potentially
driven
by
increased
iron
content
at
ectopic
sites,
may
contribute
to
progression
This
retrospective
case-control
study
provides
comprehensive
immunohistochemical
assessment
expression
tissue
distribution
established
ferroptosis
markers:
GPX4,
ACSL4,
TfR1
endometriosis
patients.
The
case
group
consisted
38
women
with
laparoscopically
histologically
confirmed
control
18
other
gynecological
conditions.
Our
revealed
significant
downregulation
GPX4
stromal
cells
patients
(
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 28, 2024
Sterigmatocystin
(STE)
is
a
mycotoxin
widely
found
in
contaminated
food
and
foodstuffs,
excessive
long-term
exposure
to
STE
associated
with
several
health
issues,
including
infertility.
However,
there
little
information
available
regarding
the
effects
of
toxin
on
female
reproductive
system,
particularly
concerning
oocyte
maturation.
In
present
study,
we
investigated
toxic
mouse
We
also
used
Western
blot,
immunofluorescence,
image
quantification
analyses
assess
impact
maturation
progression,
mitochondrial
distribution,
oxidative
stress,
DNA
damages,
ferroptosis
asymmetric
division
defects.
Our
results
revealed
that
disrupted
progression.
When
examined
cellular
changes
following
100
µM
treatment,
adversely
affected
polar
body
extrusion
induced
defects
oocytes.
RNA-sequencing
data
showed
affects
expression
pathway-correlated
genes
during
meiosis
mice,
suggesting
its
toxicity
Based
RNA-seq
data,
stress
caused
damage
Besides,
α-tubulin
acetylation
were
STE-exposed
Moreover,
determined
resulted
reduced
RAF1
protein
oocytes,
inhibition
activity
causes
Collectively,
our
research
provides
novel
insights
into
molecular
mechanisms
whereby
contributes
abnormal
meiosis.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 29, 2024
Endometriosis
(EMs)
is
the
prevalent
gynecological
disease
with
typical
features
of
intricate
pathogenesis
and
immune-related
factors.
Currently,
there
no
effective
therapeutic
intervention
for
EMs.
Disulfidptosis,
cell
death
pattern
discovered
recently,
may
show
close
relationships
to
immunity
In
this
study,
bioinformatics
analysis
was
used
investigate
role
disulfide
breakdown
related
genes
(DRGs)
in
The
EMs
gene
expression
matrix
subjected
differential
identifying
overlap
between
differentially
expressed
(DEGs)
associated
poisoning.
Immunoinfiltration
performed.
addition,
association
hub
immune
cells
examined.
Multiple
machine
learning
methods
were
employed
identify
genes,
construction
predictive
models,
validation
using
external
datasets
clinical
samples.
Totally
15
overlapping
identified.
Immune-correlation
showed
that
NK
played
a
vital
role,
these
closely
cells.
PDLIM1
further
determined
as
through
techniques.
Clinical
samples
adopted
validating
performance
diagnosis.
According
above
findings,
we
built
model,
calculated
AUCs
obtained
from
three
demonstrate
model
accuracy.
RT-qPCR
IHC
analyses
applied
confirm
results.
Colony
formation
verify
effect
on
proliferation
primary
A
strong
correlation
disulfidptosis
identified
highlighting
its
microenvironment.
Moreover,
our
results
shed
new
lights
exploring
biomarkers
potential
targets
Perm Medical Journal,
Journal Year:
2024,
Volume and Issue:
41(6), P. 56 - 67
Published: Dec. 15, 2024
Objective.
To
determine
the
risk
factors
for
recurrence
of
endometrioid
cysts
in
infertile
patients.
Materials
and
methods.
47
women
divided
into
two
distinct
groups
participated
study.
The
first
group
(n
=
39)
consisted
reproductive
age
with
infertility
associated
ovarian
cysts,
who
experienced
no
these
a
year.
Conversely,
second
8)
comprised
age,
had
within
same
timeframe.
Blood
sampling
analysis
was
performed
all
participants
before
surgery,
on
10th
day
after
operation,
6
12
months
following
surgery.
concentrations
AXIN-1
haptoglobin
were
determined
blood
plasma.
Results.
Risk
such
as
young
28.5
(27.5–31.5),
dysmenorrhea,
bilateral
lesion,
cyst
size
5
(4–6)
cm,
well
dynamics
biomarkers
revealed
A
statistically
significant
difference
level
which
reflects
presence
oxidative
stress
provoked
by
ferroptosis
beyond
them
patients
recurrent
endometriomas.
phenomenon
shown
to
contribute
fibrosis
not
only
tissues
ovary
itself,
but
also
formation
adhesions
appendages,
most
pronounced
relapse
group.
High
its
slow
decline
reflect
aggressiveness
cellular
proliferation,
bypassing
apoptosis
leading
repeated
relapse.
combination
above-mentioned
is
promising
early
detection
–
Conclusion.
clinical,
anamnestic,
intraoperative
laboratory
data
identified
recurrence:
patients`
younger
nature
lesion
Analysis
can
be
considered
criterion
an
important
aspect
planning
surgical
intervention,
since
connection
adhesive
process
revealed.
