Revisiting experimental models of erectile dysfunction and their value in drug discovery and development DOI
Hao Wang, Eric Chung

Expert Opinion on Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Erectile dysfunction (ED) is a common condition that often signals underlying endothelial although the causative factor(s) are likely complex and multifactorial. Various animal models have been developed to provide research platform study ED served as an important basis for discovery subsequent development of novel therapeutic drugs ED. The review article provides overview various in with emphasis on drug target relating each specific experimental model authors highlight translation from basic science major preclinical clinical studies this evolving field research. Animal simulate pathological features types clarify their molecular mechanisms. These mechanisms aid discovering targets, while established also validating efficacy, safety, action techniques detection methods, cellular experimental, omics has profound impact disease prediction, evaluation, optimization modalities. On basis, many therapies targeting these ED-related mechanisms, especially nitric oxide/cyclic guanosine monophosphate pathways applied studies. However, focusing those where phosphodiesterase 5 inhibitor therapy limited may be more valuable.

Language: Английский

Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages DOI Creative Commons

Zhuan Feng,

Feiyang Meng,

Fei Huo

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103255 - 103255

Published: June 24, 2024

Language: Английский

Citations

26
Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders DOI Creative Commons
Olayemi K. Ijomone, Ukwubile Ileje Inelo, Vivian O. Aneke

et al.

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 6, 2025

Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.

Language: Английский

Citations

3
Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Yusheng Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

14
Targeting Ferroptosis as an Advance Strategy in Cancer Therapy DOI
Tobias Achu Muluh, Qianqian Fu,

Xiaojiao Ai

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 41(10-12), P. 616 - 636

Published: July 3, 2024

This study innovates by systematically integrating the molecular mechanisms of iron death and its application in cancer therapy. By deeply analyzing interaction between tumor microenvironment, provides a new theoretical basis for treatment directions developing more effective strategies. In addition, points to critical issues barriers that need be addressed future research, providing valuable insights into use clinical translation.

Language: Английский

Citations

6
Oxidative stress-mediated epigenetic remodeling, metastatic progression and cell signaling in cancer DOI
Abdul Rehman Phull, Sadia Qamar Arain, Abdul Majid

et al.

ONCOLOGIE, Journal Year: 2024, Volume and Issue: 26(4), P. 493 - 507

Published: July 1, 2024

Language: Английский

Citations

6
The complex interplay between ferroptosis and atherosclerosis DOI Open Access

Mao Zhang,

Jianping Li, Wei Hu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117183 - 117183

Published: July 30, 2024

Atherosclerosis, characterized by the accumulation of plaque within arterial walls, is an intricate cardiovascular disease that often results in severe health issues. Recent studies have emphasized importance ferroptosis, a controlled type cell death dependent on iron, as critical factor this state. Ferroptosis, distinguished its reliance iron and lipid hydroperoxides, offers unique insight into pathology atherosclerotic lesions. This summary encapsulates current knowledge role ferroptosis plays onset progression atherosclerosis. It explores molecular processes through which peroxidation metabolism contribute to development atheromatous plaques evaluates possibility utilizing novel treatment approach for By illuminating relationship between ferroptosis-related atherosclerosis, review paves way future clinical applications personalized medicine approaches aimed at alleviating effects

Language: Английский

Citations

6
Hypoxia-Responsive Micelles Deprive Cofactor of Stearoyl-CoA Desaturase-1 and Sensitize Ferroptotic Ovarian Cancer Therapy DOI
Jiajia Luo,

Yaqi Shang,

Ning Zhao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122820 - 122820

Published: Sept. 11, 2024

Language: Английский

Citations

5
FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1 DOI Creative Commons
Chenfei Dong, Yue Zhang,

Jiayue Zeng

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 10, 2024

Colorectal cancer (CRC) ranks as the second most lethal worldwide because of its high rate metastasis, and approximately 20% CRC patients have metastases at initial diagnosis. Metabolic reprogramming, a hallmark cells, has been implicated in process metastasis. We previously demonstrated that fucosyltransferase 2 (FUT2) promotes malignancy however, underlying mechanisms remain unclear. Here, bioinformatic analysis revealed FUT2 is associated with malignant phenotype fatty acid metabolism CRC. knockdown decreased glucose uptake de novo synthesis, which turn inhibited proliferation metastasis cells. Mechanistically, YAP1 nuclear translocation stabilizes mSREBP-1 by fucosylation, thus promoting synthesis In summary, this study demonstrates cells reprogramming via YAP/TAZ signaling SREBP-1, indicating might be potential target for developing therapeutic strategies against

Language: Английский

Citations

5
Avicularin inhibits ferroptosis and improves cognitive impairments in Alzheimer's disease by modulating the NOX4/Nrf2 axis DOI
Zixiang Li, Yingying Lu,

Yongqi Zhen

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156209 - 156209

Published: Nov. 1, 2024

Language: Английский

Citations

5
Developing a Selection Framework for Zinc Ion-Based Biomaterial Design: Guided by the Biosafety Assessment of ZIF-8 and ZnO DOI

Yilin Mao,

Liang Wang, Zhengyi Xu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 2967 - 2982

Published: April 18, 2024

In recent years, nanomaterials have gained widespread use in the biomedical field, with ZIF-8 and ZnO emerging as promising candidates due to their remarkable performance osteogenesis, angiogenesis, antimicrobial therapy. However, before advancing these for clinical applications, it is imperative evaluate biocompatibility. particular, comparing similar functions crucial identifying most suitable further development market entry. Our study aimed compare biocompatibility of nano-ZIF-8 nano-ZnO under same conditions. We found that exhibited lower toxicity both vitro vivo compared nano-ZnO. To gain insights into underlying mechanisms responsible this difference, we conducted experiments investigate lysosome damage, mitochondrial change, occurrence ferroptosis. Additionally, performed transcriptome sequencing analyze expression relevant genes, thereby providing robust validation our findings. summary, highlighted importance evaluating effects. Through comparative study, not only shed light on superior over nano-ZnO, but also contributed valuable methodological references future material screening endeavors. Ultimately, served a stepping stone toward safer more effective various applications.

Language: Английский

Citations

4