Cellular Signalling, Journal Year: 2024, Volume and Issue: unknown, P. 111525 - 111525
Published: Nov. 1, 2024
Language: Английский
Molecular and Cellular Probes, Journal Year: 2025, Volume and Issue: 79, P. 102007 - 102007
Published: Jan. 6, 2025
Language: Английский
Citations
2
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: March 10, 2025
Non-coding RNAs (ncRNAs) have a significant role in gene regulation, especially cancer and inflammatory diseases. ncRNAs, such as microRNA, long non-coding RNAs, circular alter the transcriptional, post-transcriptional, epigenetic expression levels. These molecules act biomarkers possible therapeutic targets because aberrant ncRNA has been directly connected to tumor progression, metastasis, response therapy research. ncRNAs’ interactions with multiple cellular pathways, including MAPK, Wnt, PI3K/AKT/mTOR, impact processes like proliferation, apoptosis, immune responses. The potential of RNA-based therapeutics, anti-microRNA microRNA mimics, restore normal is being actively studied. Additionally, tissue-specific patterns ncRNAs offer unique opportunities for targeted therapy. Specificity, stability, responses are obstacles use ncRNAs; however, novel strategies, modified oligonucleotides delivery systems, developed. profiling may result more individualized successful treatments precision medicine advances, improving patient outcomes creating early diagnosis monitoring opportunities. current review aims investigate roles diseases, focusing on their mechanisms regulation implications non-invasive diagnostics therapies. A comprehensive literature was conducted using PubMed Google Scholar, research published between 2014 2025. Studies were selected based rigorous inclusion criteria, peer-reviewed status relevance Non-English, non-peer-reviewed, inconclusive studies excluded. This approach ensures that findings presented high-quality relevant sources.
Language: Английский
Citations
1
Cell Reports Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 101806 - 101806
Published: Oct. 1, 2024
Language: Английский
Citations
7
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 310 - 310
Published: April 28, 2025
The study of exosomes is currently an area major interest in the scientific world, especially after discovery their function as natural nanocarriers. Their intrinsic features regulating intricate intracellular pathways have put them spotlight last decade, and it has been considered that by harnessing them, future cellular communication therapeutic innovation will experience a breakthrough, leading to pioneering research. However, demonstrated various important roles, from conferring resistance viral infections human placenta transfer oncogenic signals between cells, reshaping metabolism, promoting angiogenesis, mediating immune evasion, serving biomarkers cancer diagnosis prognosis, having implications management certain diseases. Besides general overview nature’s nanocarriers functions, this article aims discuss PitNETs, since there many recent studies regarding clinical benefits biomolecular medicine.
Language: Английский
Citations
0
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(5), P. 1205 - 1226
Published: April 30, 2025
Noncoding RNAs (ncRNAs) are crucial regulatory molecules in various biological processes, despite not coding for proteins. ncRNAs further divided into long noncoding (lncRNAs), microRNAs (miRNAs), and circular (circRNAs) based on the size of their nucleotides. These play roles transcriptional, post-transcriptional, epigenetic regulation. The RNAs, including lncRNAs, miRNAs, circRNAs, essential modalities cellular death, such as apoptosis, ferroptosis, cuproptosis, pyroptosis, disulfidptosis, necroptosis. integral to modulating gene expression protein functionality during death mechanisms. In circRNAs influence transcription apoptotic genes. these target genes proteins involved iron homeostasis oxidative stress responses. For regulate pathways associated with accumulation copper ions, leading death. During modulate inflammatory mediators caspases, affecting proinflammatory cell pathway. necroptosis, oversee formation necrosomes, thereby influencing balance between survival Disulfidptosis is a unique type regulated caused by excessive disulfide bonds within cells, cytoskeletal collapse stress, especially under glucose-limited conditions. This investigation highlights complex mechanisms through which coordinate emphasizing therapeutic promise potential targets, particularly domain cancer treatment.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 22, 2024
Pituitary neuroendocrine tumors are common, typically benign intracranial neoplasms arising from well-differentiated anterior pituitary cells with prevalence of clinically relevant tumor 89 in 100 000 people. Despite the growing number published studies, there is still a need for diagnostic and predictive biomarkers adenomas. Prompt determination tendency invasive growth aggressive behavior would allow earlier more effective treatment. Extracellular vesicles (EVs), including exosomes, particles released by containing cell-specific cargo variety bioactive molecules, such as DNA, messenger RNA, microRNA, long non-coding circular proteins, lipids surrounded lipid membranes, which act mediators cell to communication. The ability exosomes reflect functional state tumor, transport informative accessibility body fluids make them promising candidates search new therapeutic methods. This study aims investigate involvement pathology adenoma their potential clinical applications.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5271 - 5271
Published: May 12, 2024
The coordinated action of VEGF, IGF1/2 and H19 factors influences the development endometriosis. aim this study was to analyze expression level these genes in patients with group consisted 100 who were diagnosed endometriosis on laparoscopic pathological examination. control found be free during surgical procedure whose eutopic endometrium wasnormal histopathological These operated for uterine fibroids. Gene determined by RT-PCR. VEGF gene significantly higher samples classified as clinical stage 1-2 compared material (p < 0.05). There also a statistically significant difference between studied at stages 3-4 0.01). higher. IGF1 lower both 0.05 cases). reported studies suggest roles IGF pathogenesis
Language: Английский
Citations
1
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: July 24, 2024
Abstract Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial (PAD). Various types cells, but not limited to endothelial cells (ECs), smooth muscle (VSMCs), and macrophages (MΦs), play crucial roles in pathogenesis DM-PAD. Long non-coding RNAs (lncRNAs) are epigenetic regulators important cellular function, their dysregulation DM can contribute PAD. This review focuses on developing field lncRNAs emerging linking We studies investigating role processes contributing DM-PAD, those ECs, VSMCs, MΦ. By examining intricate molecular landscape governed by these relevant cell types, we hope shed light EC dysfunction, inflammatory responses, remodeling Additionally, provide an overview research approach methodologies, from identifying disease-relevant characterizing functions context also discuss potential leveraging diagnosis therapeutics for Collectively, this provides summary lncRNA-regulated DM-PAD highlights translational lncRNA biology tackle increasingly prevalent complex disease. Graphical
Language: Английский
Citations
1
Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Language: Английский
Citations
1
Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1999 - 1999
Published: Dec. 3, 2024
Neuroendocrine prostate cancer (NEPC), an aggressive and lethal subtype of (PCa), often arises as a resistance mechanism in patients undergoing hormone therapy for adenocarcinoma. NEPC is associated with significantly poor prognosis shorter overall survival compared to conventional adenocarcinoma due its nature limited response standard care therapies. This transdifferentiation, or lineage reprogramming, characterised by the loss androgen receptor (AR) prostate-specific antigen (PSA) expression, upregulation neuroendocrine (NE) biomarkers such neuron-specific enolase (NSE), chromogranin-A (CHGA), synaptophysin (SYP), neural cell adhesion molecule 1 (NCAM1/CD56), which are critical diagnosis. The AR expression culminates PCa therapies, androgen-deprivation (ADT) target signalling axis. review explores drivers NE transdifferentiation. Key genetic alterations, including those tumour suppressor genes RB1, TP53, PTEN, changes epigenetic regulators, particularly involving EZH2 cell-fate-determining transcription factors (TFs) SOX2, play significant roles promoting transdifferentiation facilitate switch from NEPC. recent identification several other key novel MYCN, ASCL1, BRN2, ONECUT2, FOXA2, further elucidates complex regulatory networks pathways involved this process. We suggest that, given multifactorial NEPC, therapeutic strategies that combine multiple modalities essential overcome improve patient outcomes.
Language: Английский
Citations
1