Brain Behavior and Immunity Integrative, Journal Year: 2024, Volume and Issue: 7, P. 100070 - 100070
Published: July 1, 2024
Language: Английский
Molecular Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Cancer's notorious heterogeneity poses significant challenges, as each tumor comprises a unique ecosystem. While single‐cell and spatial transcriptomics advancements have transformed our understanding of diversity within tumors, the temporal dimension remains underexplored. Tumors are dynamic entities that continuously evolve adapt, relying solely on static snapshots obscures intricate interplay between cancer cells their microenvironment. Here, we advocate for integrating dynamics into research, emphasizing fundamental shift from traditional endpoint experiments to data‐driven, continuous approaches. This integration involves, instance, development advanced live imaging techniques, innovative omics methodologies, novel computational tools.
Language: Английский
Citations
0
Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 295 - 295
Published: March 22, 2025
Porcine respiratory and reproductive syndrome is a viral disease that impacts the health profitability of swine farms, largely due to significant variation in vaccination response. The objective was identify validate molecular markers associated with antibody response gilts following against PRRSV. study included one hundred (n = 100) 6-month-old Yorkshire were negative for Gilts randomly assigned two treatments, PRRS-vaccinated 75) control 25) groups. Blood samples collected on day 21 analyzed evaluate response, as indicated by sample-to-positive (S/P) ratio, PRRSV vaccination. DNA extracted genotyped using low-density chip containing 10,000 single nucleotide polymorphisms (SNPs). A genome-wide association (GWAS) conducted candidate SNPs S/P which validated independent gilt populations 226). rs707264998, rs708860811, rs81358818 genes RNF144B, XKR9, BMAL1, respectively, significantly (p < 0.01) ratio demonstrated an additive effect. In conclusion, three are proposed enhanced immune may be beneficial genetic selection programs.
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 29, 2025
Abstract Sleep is an indispensable physiological function regulated by circadian rhythms, which influence the biological pathways and overall health of body. crucial for maintenance restoration bodily systems, disturbances can lead to various sleep disorders, impair both mental physical health. Treatment options these disorders encompass lifestyle modifications, psychotherapy, medications, therapies such as light therapy surgery. Not only deprivation has a significant impact on essential organs, but it also influences types stem cells in In this review, we explore connection between cells, highlighting how rhythms regulate cell activities that are vital tissue regeneration homeostasis. Disruptions hinder self-renewal, homing, proliferation, function, differentiation, thereby affecting We discuss transplantation their products may help improve quality affects behavior, implications therapies. Notably, while certain transplantations disrupt sleep, enhancing efficacy Finally, be utilized model offering valuable insights into underlying mechanisms.
Language: Английский
Citations
0
Nutrition Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Cellular Biochemistry, Journal Year: 2025, Volume and Issue: 126(4)
Published: March 31, 2025
ABSTRACT Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as life‐supporting mechanism over 500 million years ago. Although fundamental purpose mechanisms remain unclear, sleep's evolution adaptive significance continue be debated. This study explores the evolutionary origins of sleep using Chlamydomonas reinhardtii model organism, identifying 112 putative sleep‐related genes across species highlighting conservation sleep‐regulatory pathways. Additionally, discovering uncharacterized proteins with high sequence similarity significant e‐values suggests unexplored roles regulation, underscoring potential C. reveal new insights into molecular basis sleep. provides foundation for previously unknown sleep‐associated proteins, particularly within single‐celled which may offer novel perspectives on biological role The demonstrates that phylogenomic analysis organisms can expand our understanding trajectory function, paving way further research biology health implications. Overall, functions higher animal phyla originated primordial activities, demonstrating an continuum wherein more specialized tasks were integrated essential restorative properties.
Language: Английский
Citations
0
Journal of Pineal Research, Journal Year: 2025, Volume and Issue: 77(3)
Published: April 1, 2025
ABSTRACT Disruption of the circadian clock has been closely linked to initiation, development, and progression cancer. This study aims explore impact rhythm disruption (CRD) on triple‐negative breast cancer (TNBC). We analyzed bulk single‐cell RNA sequencing data assess status in TNBC using multiple bioinformatic tools, alongside metabolomic profiles tumor microenvironment evaluations understand influence CRD metabolic reprogramming immune evasion. The results indicate that experiences profound CRD. Patients with a higher CRDscore exhibit significantly poorer relapse‐free survival compared those lower CRDscore. Cyclic ordering by periodic structure (CYCLOPS) identified significant changes rhythmic gene expression patterns between normal tissues, showing “rush hour” effect, where peak times are concentrated within specific time windows. Transcripts disrupted rhythms were found be involved key pathways related cell cycle regulation, metabolism, response. Metabolomic analysis further revealed TNBCs high enriched carbohydrate amino acid metabolism pathways, notably upregulation tryptophan metabolism. High was also an immunosuppressive microenvironment, characterized reduced infiltration, exhausted CD8 + T cells, diminished response checkpoint blockade therapy. These findings suggest molecular may activate thereby promoting evasion potentially reducing effectiveness immunotherapy.
Language: Английский
Citations
0
Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Citations
0
Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 386 - 386
Published: April 20, 2025
The objective of the present study was to investigate influence daily rhythms on immune and inflammatory systems in horses, considering white blood cell count (WBCs), leukocyte subpopulations (neutrophils, basophils, eosinophils, lymphocytes, monocytes), CD4+, CD8+ lymphocyte populations, interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α). Ten Italian Saddle horses (7–12 years old, body weight 480 ± 30 kg) underwent sampling every 4 h over a 24-h period. COSINOR method used identify their parameters. A one-way analysis variance (ANOVA) applied differences acrophase robustness, multiple correlation model (Pearson) evaluate relationships among investigated WBCs, subpopulations, CD8+, IL-1β, IL-6, TNFα exhibited rhythmicity. In particular, IL-6 reached acrophases during dark phase, while neuthrophils, showed diurnal acrophase. One-way ANOVA statistical difference parameters (p < 0.0001). Pearson matrix positive negative Circadian should be taken into consideration with fluctuations biomarkers develop good management practices improve welfare horses.
Language: Английский
Citations
0
Cell and Tissue Research, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Language: Английский
Citations
2